2015
DOI: 10.1038/srep14540
|View full text |Cite
|
Sign up to set email alerts
|

Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth

Abstract: We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10th–90th percentile; n = 42) or LGA (>90th percentile; n = 29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Genome-wide DNA methylation wa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
19
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
6
1

Relationship

2
5

Authors

Journals

citations
Cited by 20 publications
(22 citation statements)
references
References 48 publications
1
19
0
Order By: Relevance
“…The mechanisms linking LGA and later health consequences are debatable as well. For instance, while experimental evidence indicated that overnutrition may program MetS through epigenetic changes , such alterations were not observed in LGA infants at birth . Although the present study accords with our predecessors and suggests LGA may not relate to later cardiometabolic outcomes, as only a few studies have been performed on growth outcomes in LGA infants, further research is warranted to clarify these outcomes.…”
Section: Discussionsupporting
confidence: 65%
See 1 more Smart Citation
“…The mechanisms linking LGA and later health consequences are debatable as well. For instance, while experimental evidence indicated that overnutrition may program MetS through epigenetic changes , such alterations were not observed in LGA infants at birth . Although the present study accords with our predecessors and suggests LGA may not relate to later cardiometabolic outcomes, as only a few studies have been performed on growth outcomes in LGA infants, further research is warranted to clarify these outcomes.…”
Section: Discussionsupporting
confidence: 65%
“…The mechanisms linking LGA and later health consequences are debatable as well. For instance, while experimental evidence indicated that overnutrition may program MetS through epigenetic changes (39), such alterations were not observed in LGA infants at birth (40).…”
Section: Discussionmentioning
confidence: 99%
“…This is a new finding, given that up to now limited information has been available on growth in LGA children. Few previous studies have mainly assessed physical growth in the LGA population during the first 4–6 years of life . Some of these studies have shown a catch‐down growth in LGA children during the first months of life .…”
Section: Discussionmentioning
confidence: 99%
“…However, little is known on the relationship between being born LGA and pubertal growth. Few studies have assessed physical growth in terms of height and weight gain in LGA children during the first four to six years of life . Whereas some of these studies have reported a catch‐down growth in children born LGA during the first years of life , other studies have shown that those born LGA tend to remain longer and heavier during the first years of life compared to their peers .…”
Section: Introductionmentioning
confidence: 99%
“…However, these tools may fail to detect significant DMRs in complex diseases or heterogeneous phenotypes, where there might be small differences among methylation signals but consistent across the analyzed regions and samples. Therefore, no individual CpGs or regions may meet the threshold for statistical significance in many studies, although there may be biologically meaningful differences (see for example Bohlin et al, 2015;Chiavaroli et al, 2015;van Dongen et al, 2015;Gervin et al, 2012;Kim et al, 2017).…”
Section: Introductionmentioning
confidence: 99%