Infantile Tremor Syndrome

Assessment of iron, folate and vitamin B12 status in children with infantile tremor syndrome

“…15,16 In our study 6 -12 mo age group was significantly associated with ITS which is similar to previous studies but Sachdev et al reported that 13-18 mo was most affected group. 4,9,10,12,13,17,18 Mean age of our study population was 13.72 mo which is similar to study by Udani et al (13.9mo). Like previous studies there was slight preponderance of ITS in boys in our study also though the difference is not statistically significant.…”

“…Bajpai et al, Sachdev et al and Garg et al also reported that all children in their study were from lower socioeconomic status. 10,12,13 Similarly Ramkumar et al and Arya et al also found that majority of their patients with ITS were from lower socioeconomic status. 9,14 Mothers of significant number of these patients were illiterate and housewives whereas fathers were either illiterate or literate up to primary standard and unskilled laborers.…”

“…Serum ferritin, folate and vitamin B 12 were estimated by electrochemiluminiscence (ECL) method using VIT B12 600, FOL III 618 and FERRITIN 381 ELECSYS kits for COBASe411 analyzer, Roche diagnostics GmBH Germany distributed by Roche diagnostics GmBH, Sandhofer Strasse 116 Manheim. Deficiencies were labeled when serum ferritin concentration was <12ng/ml, or <30ng/ml if the CRP was positive, serum folate concentration <10nmol/L (4 ng/ml) and serum vitamin B 12 concentration <150pmol/L (203 pg/ml).…”

“…1 Various theories has been postulated about etiopathogenesis of ITS including nutritional deficiency, infections, toxins and enzyme defects but none has been substantiated so far. [1][2][3][4] Although the mechanisms underlying the effect of maternal folate status on neural tube development are not well understood, the shared metabolism between folate and vitamin B 12 suggests that deficiencies in one vitamin may alter the metabolism of the other. This is perhaps related to the roles that vitamin B 12 plays in myelination, or in the synthesis of methionine from homocysteine in combination with folic acid.…”

“…This is perhaps related to the roles that vitamin B 12 plays in myelination, or in the synthesis of methionine from homocysteine in combination with folic acid. This review was conducted to examine the evidence linking deficiencies in maternal and infant folate and/or vitamin B 12 with infant cognitive and motor development iency.…”