Infantile Spasms and Skin Anomalies

Crichton, John U.

doi:10.1111/j.1469-8749.1966.tb01747.x

Cited by 18 publications

(6 citation statements)

References 20 publications

(6 reference statements)

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“…and early appearance, being sometimes the earliest visible symptom. Recent reports in the literature confirm their importance (Gold and Freeman, 1965;Crichton, 1966).…”

Section: Discussionmentioning

confidence: 84%

Tuberous Sclerosis: A Clinical and Genetical Investigation*

Zaremba

1968

J intellect Disabil Res

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“…and early appearance, being sometimes the earliest visible symptom. Recent reports in the literature confirm their importance (Gold and Freeman, 1965;Crichton, 1966).…”

Section: Discussionmentioning

confidence: 84%

Tuberous Sclerosis: A Clinical and Genetical Investigation*

Zaremba

1968

J intellect Disabil Res

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“…These have been fully outlined elsewhere (Crichton 1966). In essence the case-notes of 310 children were examined.…”

Section: Methodsmentioning

confidence: 99%

Infantile Spasms in Children of Low Birth weight

Crichton

1968

Develop Med Child Neuro

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SUMMARY In a retrospective study of 242 children with infantile spasms 31 were found to have a birthweight below the 10th percentile for the length of gestation and of these 26 (84 per cent) were of the secondary variety. Of these 26 infants, 16 had developed a serious convulsive disorder one to five days after birth. Only 3 similar cases were encountered in the other 211 children. By comparing these figures with the numbers of premature and ‘small for dates’ (sfd) infants in the general population, it is concluded that sfd infants are 3 times as likely to develop infantile spasms as true prematures weighing less than 2,500 g. RÉSUMÉ Au cours d'une étude rétrospective d'enfants atteints de spasmes infantiles, on a rencontre 31 enfants parmi les 242 étudiés dont le poids de naissance était inférieur à dix pour cent pour la duration de gestation, et, parmi ceux‐ci, 26 (84 pour cent) étaient de la variété secondaire. Parmi ces 26 enfants, six ont développé des désordres convulsifs sérieux entre le premier et le cinquième jour après la naissance, mais seulement trois cas similaires ont été rencontres chez les 21 enfants restant. En comparant ces chiffres aux nombres de prematures et bébés ‘petits pour la date’ (sfd) dans la population générale, on conclut que les bébés sfd ont trois fois plus de chance d'avoir des spasmes infantiles. ZUSAMMENFASSUNG Im Laufe einer retrospektiven Studie von Kindern mit infantilen Krämpfen stiess man auf 31 Kinder aus einer Gesamtzahl von 242, deren Geburtsgewicht unter dem lo. Prozentteil für die Dauer der Schwangerschaft war und von diesen waren 26 (84 prozent) von der sekundären Varietät. Von diesen 26 Säuglingen hatten 16 eine schwere konvulsive Störung ein bis fünf Tagen nach der Geburt entwickelt, obgleich man nur drei ähnlichen Fällen unter den anderen 211 Kindern begegnete. Beim Vergleich dieser Zahlen mit Anzahl der frühreifen und verhältnismässig kleinen (‘small for dates’—sfd) Säuglinge in der allgemeinen Bevölkerung, kommt man zum Schluss dass bei sfd‐S äuglingen die Möglichkeit infantile Krämpfe zu entwickeln, dreimal grösser ist. RESUMEN Durante un estudio retrospectivo de niños afectos de espasmos infantiles se encontraron 31 de 242 cuyo peso era debajo de la décima percentila para la duración de la gestación, y de èstos 26 (un 84 por ciento), eran del tipo secundario. De estos 26 lactantes, 16 habían presentado un desorden convulsivo grave entre un día y cinco días después de nacer, aunque no había más que tres casos parecidos entre los otros 211 niños. Como consecuencia de comparar estas cifras con el número de lactantes prematuros y pequeños para la duración de la gestación, se concluye que es tres veces más probable que tales niños tengan espasmos infantiles.

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“…19,33,47 The contribution to the etiology discovery in the 1960s relied in the clinical examination, limited X-ray evaluations, cerebrospinal fluid analysis, and pathologic examination reports. 58,59 The association of infantile spasms with tuberous sclerosis was recognized by Della Rovere et al in 1964 60 and Crichton in 1966 61 who identified various skin-associated lesions in 43 of a series of 174 children with infantile spasms and tuberous sclerosis. It was also recorded that the diagnosis of tuberous sclerosis had prognostic implications given its genetic basis.…”

Section: The Introduction Of the Benzodiazepinesmentioning

confidence: 98%

Historical Overview of Hypsarrhythmia and Its Association to Epileptic Spasms: A Review of the Medical Literature From 1952 to 1982

Pestana-Knight

Mani

2022

Journal of Clinical Neurophysiology

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Summary:The initial description of infantile spasms and its association to developmental abnormalities was attributed to Dr. Williams J. West in 1841 but the clinical scenario at the time had also been seen by other physicians. French physician Henry Gastaut proposed the eponym of West syndrome in the 9th Colloquium de Marseille in 1960. The description of hypsarrhythmia in 1952 by Gibbs and Gibbs added the EEG component to the triad of infantile spasms. The hypsarrhythmia discovery led to a sudden interest in understanding the etiology and developing treatments for this devastating disease affecting infants and young children. It was in the 1950s when cases of infantile spasms with absence of hypsarrhythmia were initially observed. Also, the treatment with adrenocorticotrophic hormone was initially reported as efficacious for treating infantile spasms and hypsarrhythmia in the late 1950s. Adrenocorticotrophic hormone remains the best treatment option for these epilepsy types. This article will provide a historical review of knowledge developments about hypsarrhythmia and infantile spasms, emphasizing the period 1952 to 1982. The goal of the article was to highlight clinical elements that were discovered then and remain clinically relevant today.

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Infantile Spasms and Skin Anomalies

Cited by 18 publications

References 20 publications

Tuberous Sclerosis: A Clinical and Genetical Investigation*

Tuberous Sclerosis: A Clinical and Genetical Investigation*

Infantile Spasms in Children of Low Birth weight

Historical Overview of Hypsarrhythmia and Its Association to Epileptic Spasms: A Review of the Medical Literature From 1952 to 1982

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