Infantile-onset cutaneous T-cell lymphoma

Abstract

The diagnosis of CTCL is frequently delayed in young children. It needs to be considered in chronic 'eczematous' skin lesions irrespective of the patient's age, and including infants.

Childhood mycosis fungoides with a CD8+ CD56+ cytotoxic immunophenotype

“…6,7 Individual cases have even been described in infancy. 13 As illustrated in the case presented, several reasons may account for the significant delay in diagnosis. At first, because of the rarity of MF in childhood more common dermatoses are primarily assumed.…”

“…In adults, only 5–10% of patients with MF have a cytotoxic immunophenotype . In contrast, cytotoxic proteins are more frequently expressed in childhood MF where two studies observed expression in 38 and 67% of cases, respectively .…”

“…The mean age at diagnosis in children is between 9 and 13 years, but symptoms frequently begin several years earlier, at a mean age of 7.5–9 years . Individual cases have even been described in infancy …”

Rare Skin Tumours in Childhood: Review

“…[28][29][30][31] On ay kadar küçük yaşta başlayan olgu bildirilmiştir. 32 Tedaviye dirençli kronik dermatozlarda düşünülmesi ve seri biyopsi alınması gerekebilir.…”

“…Genelde çocukluk çağı mikozis fungoidesleri daha sınırlı olmakta ve erişkinlere göre hastalığa bağlı yaşam süresi daha iyi görünmekte-dir. [31][32][33][34] Bununla birlikte, hastalık yine de kronik seyretmekte ve tedavi kesildiğinde yeniden başla-yabilmektedir. Hastalığın benign olmadığı ve de tedavi gerektirdiğinin bilinmesi önemle vurgulanmalıdır.…”