Infantile Nystagmus and Visual Deprivation: Foveal Instability and Refractive Development in a Low Vision Register Series

Fledelius, Hans C.; Jensen, Hanne

doi:10.5301/ejo.5000409

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…There was more astigmatism in the albino (Albinism is inherited conditions in which there is a lack of pigmentation in the eyes and usually in the skin and hair as well) group (primarily with-the-rule; where the vertical meridian is steepest). 14 While In other study adolescent and adults myopic in albinos were less than idiopathic Congenital Nystagmus, [14][15][16][17][18][19][20] but in this recent study it no difference was found in type of refractive error result but study sample size was different. In our study only n=20 eyes were found hypermetric.…”

Section: Resultsmentioning

confidence: 63%

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Refractive Error in Juvenile Patients Presenting with Nystagmus at Tertiary Care Hospital of Karachi

Perveen¹,

Ahmed²,

Perveen³

et al. 2021

J. Bahria Univ. Med. Dent. Coll.

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Objective: To evaluate the types of refractive errors in nystagmus patients among the age (5-15 years) patients. Study Design and Setting: An observational cross-sectional study was conducted at Pediatric department of Al-Ibrahim Eye Hospital, Karachi from June 2018 to March 2019. Methodology: A total of 55 patients (110 eyes) were selected from study setting. The protocol for examination for all patients were evaluated at the special clinic of Orthoptics includes the demographic data, educational status, history of onset, type of nystagmus. The anterior segment was examined with a slit-lamp to exclude any other ocular disease. Orthoptic assessment includes cover uncover test, Hirschberg, ocular motility, prism cover test and pupillary reflex test, to observe any associated deviation. All the patients were examined after obtaining a fully informed consent. After the proper diagnosis of nystagmus patient was recruited as per inclusion and exclusion criteria with no restrictions of gender. All the observations were noted on a Proforma, Data analysis was done by using SPSS version 20. P-value <0.05 was considered as statistically significant. RESULTS: A total of 55 patients, 29 male (52.7%) and 26 female (47.3%) were selected. This study shows out of 55 patients (110 eyes), 46 (42%) eyes had myopic astigmatism, while 33 (30%) eyes were found hyperopic astigmatism, 20 (18%) eyes were observed hyperopic and 11 (10%) eyes were observed myopic. CONCLUSION: Most common type of refractive error in nystagmus was myopic astigmatism. The refractive correction should be encouraged in children with nystagmus; improvement in visual function is likely to occur

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Section: Resultsmentioning

confidence: 63%

“…A study in 2011 data showed Out of total 170 Down Syndrome patients Nystagmus was observed in 18 patients. 15 Children with nystagmus had greater association of Myopia and astigmatism 16 . Some studies shows increment in Astigmatism with age 17 caused by constant oscillations of the eyeball.…”

Section: Discussionmentioning

confidence: 99%

Refractive Error in Juvenile Patients Presenting with Nystagmus at Tertiary Care Hospital of Karachi

Perveen¹,

Ahmed²,

Perveen³

et al. 2021

J. Bahria Univ. Med. Dent. Coll.

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“…Nystagmus‐blocking gaze directions reduce the ocular unrest and prolong foveation periods, but hardly allows stable fixation. Theoretically, deprivation‐like mechanisms are triggered, which might fit into the factual pattern of more myopia in our recent series than in the population (Fledelius & Jensen ). This is in keeping with two other studies (Nathan et al.…”

Section: The Two Main Themesmentioning

confidence: 52%

“…This issue was analysed in a recent study (Fledelius & Jensen ). Hereditary factors are acknowledged in only a low percentage in infantile nystagmus syndrome, and most cases appear sporadic (Abel ; Hertle ).…”

Section: The Two Main Themesmentioning

confidence: 99%

Human parallels to experimental myopia? A literature review on visual deprivation

Fledelius

Goldschmidt²,

Haargaard

et al. 2014

Acta Ophthalmologica

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Raviola and Wiesel's monkey eyelid suture studies of the 1970s laid the cornerstone for the experimental myopia science undertaken since then. The aim has been to clarify the basic humoral and neuronal mechanisms behind induced myopization, its eye tissue transmitters in particular. Besides acquiring new and basic knowledge, the practical object of the research is to reduce the burden of human myopia around the world. Acquisition and cost of optical correction is one issue, but associated morbidity counts more, with its global load of myopia-associated visual loss and blindness. The object of the present PubMed literature-based review is to evaluate apparent similarities between experience from disturbed imaging in experimental laboratory science and varieties within the spectrum of childhood human myopia. So far, the main impression is that macroscopical optical deprivation appears absent in the prevalent types of human myopia, nor is myopia a regular sequel where early eye pathology has led to poor imaging and optical deprivation. Optical aberrations of a higher order are a relatively new issue in myopia research, and microstructural deprivation is only marginally dealt within the survey. Links between experimental and human myopia appear mainly occasional, and with only few examples in humans where factual parallels appear credible. Clinical and epidemiological data on refraction remain important, in particular with a view to life style and environmental factors. Such knowledge may further serve as inspiration to the laboratory research, which aims at solving the basic enigmas on a tissue level.

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Retinal microstructures are altered in patients with idiopathic infantile nystagmus

Han

Lee

2017

Graefes Arch Clin Exp Ophthalmol

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Infantile Nystagmus and Visual Deprivation: Foveal Instability and Refractive Development in a Low Vision Register Series

Abstract: The prevalence of myopia and astigmatism was higher among children with nystagmus than in controls. Myopia was mainly juvenile, and not related to the period of infancy when the motor foveal smear is considered most disturbing and possibly influencing visual development.

Cited by 3 publications

References 43 publications

Refractive Error in Juvenile Patients Presenting with Nystagmus at Tertiary Care Hospital of Karachi

Refractive Error in Juvenile Patients Presenting with Nystagmus at Tertiary Care Hospital of Karachi

Human parallels to experimental myopia? A literature review on visual deprivation

Retinal microstructures are altered in patients with idiopathic infantile nystagmus

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