Infantile hemangiomas: a 7-year experience of a single-center

Abstract

ObjectivesThe aim of the study was to describe the historical and clinical characteristics of hemangiomas in a series of cases of our clinic.MethodsThis is a retrospective study of 36 patients with infantile hemangiomas consulted in our clinic.ResultsWe had 14 multiple hemangiomas, and 1 kaposiform hemangioendothelioma. Almost two-thirds involved the cephalic extremity, and 76% of the cases were treated. Pregnancy risk factors included prematurity, low-birth weight and respiratory distress syndrome. Propranolol was used in 22 cases, followed by prednisone in 3 cases. Vincristine and interferon were used as associated therapies or as second line therapies. Two hemangiomas had complications, one ulceration and a Kasabach-Merritt syndrome. All the patients had a good evolution.ConclusionsOur study results regarding the involvement of pregnancy and birth risk factors in developing infantile hemangiomas is similar to literature data. The majority of patients had at least one risk factor suggesting that at least one trigger to develop an infantile hemangioma is necessary. Our study shows that the cephalic extremity is mostly involved, and because of its potential complications they are most likely to be treated. The study shows that propranolol is the leading treatment option with few and mild side effects.

Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two

“…Although some doctors previously did not advocate using propranolol as a treatment of IHs in premature infants, recent studies indicated that oral propranolol is safe for preterm and low-birth-weight infants [9, 33, 34]. It was reported that children who start oral propranolol at less than 1 month of age are more likely to develop asymptomatic bradycardia and hypotension [27].…”

Anomalies vasculaires cutanées au Togo : étude de 120 cas

“…Nous avons noté une prédominance féminine au cours des anomalies vasculaires cutanées notamment les HI et les AP, ce qui est classique au cours des HI [2,3,10,18] et des AP [7,9].…”

“…Concernant la localisation des lésions, la plupart des lésions d'HI siégeaient à la région céphalique (50,5 %). Ces résultats concordent avec ceux de Bota et al en 2017 [3] et de Adams et al en 2018 [1]. Pour ce qui concerne les AP, la localisation préférentielle, dans notre étude, était la région céphalique (50 %) surtout la face (31,4 %).…”

“…Aucun cas de syndrome de Kasabach-Merritt n'avait été noté. Bota et al [3] avaient décrit deux complications dans leur série de 36 patients (une ulcération et un syndrome de Kasabach-Merritt). Chamblin et al en avaient retrouvé 9,8 % dans leur série [4].…”

The prevalence, complications, and risk factors for infantile hemangioma: a systematic review and meta‐analysis

“…27 studies [7][8][9] investigated prevalence, mainly in America, Germany, Canada, Israel, Japan, Australia, Netherlands, Denmark, China, Mali, and Brazil. 27 studies 7,12,28,[35][36][37]44,45,47,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] reported the distribution of IH lesions, and 14 studies 7,12,35,[50][51][52]55,57,59,61,63,64,68,69 surveyed the occurrence of complications. Specifically, 28 studies 7,9,16,[30][31][32]…”