Inescapable shock activates serotonergic neurons in all raphe nuclei of rat

Takase, Luiz Fernando; Nogueira, Maria Inês; Baratta, Michael V.; Bland, Sondra T.; Watkins, Linda R.; Maier, Steven F.; Fornal, Casimir A.; Jacobs, Barry L.

doi:10.1016/j.bbr.2003.12.020

Cited by 69 publications

(45 citation statements)

References 17 publications

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“…Fos expression did not differ in the MUS and VEH HC day 1 groups, and so these groups were pooled. It should be noted that previous work (Grahn et al, 1999;Takase et al, 2004;Amat et al, 2005) has indicated that there is virtually no Fos expression in 5-HT-labeled DRN neurons in home-cage control subjects. Thus, it can be presumed that the Fos observed was induced by the IS.…”

Section: C-fos Expression In 5-ht-labeled Neurons In the Drnmentioning

confidence: 87%

Previous Experience with Behavioral Control over Stress Blocks the Behavioral and Dorsal Raphe Nucleus Activating Effects of Later Uncontrollable Stress: Role of the Ventral Medial Prefrontal Cortex

Amat

Paul²,

Zarza³

et al. 2006

J. Neurosci.

210

212

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Previous experience with stressors over which the subject has behavioral control blocks the typical behavioral consequences of subsequent exposure to stressors over which the organism has no behavioral control. The present experiments explored the involvement of the ventral medial prefrontal cortex (mPFCv) in mediating this "immunizing" or resilience producing effect of an initial experience with control. Behavioral immunization was blocked by inactivation of the mPFCv with muscimol at the time of the initial experience with control, as well as at the time of the later exposure to uncontrollable stress. Inhibition of protein synthesis within the mPFCv by anisomycin also blocked immunization when administered at the time of the initial controllable stress but had no effect when administered at the time of the later uncontrollable stress. Additional experiments found that the initial experience with control blocks the intense activation of serotonergic cells in the dorsal raphe nucleus that would normally be produced by uncontrollable stress, providing a mechanism for behavioral immunization. Furthermore, mPFCv activity during the initial controllable stressor was required for this effect to occur. These results suggest that the mPFCv is needed both to process information about the controllability of stressors and to utilize such information to regulate responses to subsequent stressors. Moreover, the mPFCv may be a site of storage or plasticity concerning controllability information. These results are consistent with recent research in other domains that explore the functions of the mPFCv.

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Section: C-fos Expression In 5-ht-labeled Neurons In the Drnmentioning

confidence: 87%

Previous Experience with Behavioral Control over Stress Blocks the Behavioral and Dorsal Raphe Nucleus Activating Effects of Later Uncontrollable Stress: Role of the Ventral Medial Prefrontal Cortex

Amat

Paul²,

Zarza³

et al. 2006

J. Neurosci.

210

212

View full text Add to dashboard Cite

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“…In one hand, some evidence indicates that Pb affects monoamine levels in the brain including serotonin (Leret et al, 2002), which is widely distributed throughout the brain and, in particular, in regions associated with anxiety (Linthorst, 2005). In another hand, the serotonin neurotransmission modulates several physiological and behavioural functions that include affective states, as well as stress-related responses and anxiety (Takase et al, 2004). …”

Section: Discussionmentioning

confidence: 99%

Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats

Seddik¹,

Bah

Aoues³

et al. 2011

J. Toxicol. Sci.

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“…Following exposure to stressors such as inescapable shock serotonin neuron activity is increased, as evidenced by increased immediate-early gene expression in the DRN (Amat et al, 2005;Grahn et al, 1999;Takase et al, 2004). A large literature also demonstrates that extracellular fluid concentrations (ECF) of serotonin are increased in both the vicinity of the DRN and the corticolimbic targets of the serotonin system, including the mPFC, amygdala and hippocampus.…”

Section: Serotonin Releasementioning

confidence: 99%

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Holmes

2008

Neuroscience & Biobehavioral Reviews

243

166

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The serotonin system is strongly implicated in the pathophysiology and therapeutic alleviation of stress-related disorders such as anxiety and depression. Serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (Pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3A, 5-HT4, 5-HT5A, 5-HT6, 5-HT7), reuptake (serotonin transporter), and degradation (monoamine oxidase A). A growing body of evidence from preclinical rodents models, and especially genetically modified mice and inbred mouse strains, has provided significant insight into how genetic variation in these molecules can affect the development and function of a key neural circuit between the dorsal raphe nucleus, medial prefrontal cortex and amygdala. By extension, such variation is hypothesized to have a major influence on individual differences in the stress response and risk for stress-related disease in humans. The current article provides an update on this rapidly evolving field of research.

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Inescapable shock activates serotonergic neurons in all raphe nuclei of rat

Cited by 69 publications

References 17 publications

Previous Experience with Behavioral Control over Stress Blocks the Behavioral and Dorsal Raphe Nucleus Activating Effects of Later Uncontrollable Stress: Role of the Ventral Medial Prefrontal Cortex

Previous Experience with Behavioral Control over Stress Blocks the Behavioral and Dorsal Raphe Nucleus Activating Effects of Later Uncontrollable Stress: Role of the Ventral Medial Prefrontal Cortex

Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

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