Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats

Seddik, Leila; Bah, Thierno Madjou; Aoues, Abdelkader; Slimani, Miloud; Benderdour, Mohamed

doi:10.2131/jts.36.797

Cited by 38 publications

(25 citation statements)

References 55 publications

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“…Likewise the liver, OLE has cardioprotective and neuroprotective effects. Oleuropein reduced cardiac infarct size, and the circulating lipid levels in normal and hypercholesterolemic rabbits subjected to ischemia .…”

Section: Discussionmentioning

confidence: 99%

“…Several experimental studies have shown that olive leaf extract (OLE) or its constituents, such as oleuropein, had protective effects in atherosclerosis, diabetes, hypertension, cardiotoxicity, neurotoxicity, gastric lesions and cancers . OLE attenuated cardiac, hepatic and metabolic changes in rats with metabolic syndrome .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, olive leaf is considered to be one of the most potent natural anti-oxidants by its chemical content. [11][12][13] Several experimental studies have shown that olive leaf extract (OLE) or its constituents, such as oleuropein, had protective effects in atherosclerosis, 14 diabetes, 15 hypertension, 16 cardiotoxicity, 17,18 neurotoxicity, 19,20 gastric lesions 21,22 and cancers. 23,24 OLE attenuated cardiac, hepatic and metabolic changes in rats with metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Çoban

Öztezcan

Doğru‐Abbasoğlu

et al. 2014

Geriatrics & Gerontology International

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Çoban

Öztezcan

Doğru‐Abbasoğlu

et al. 2014

Geriatrics & Gerontology International

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“…Exposure to Pb 2+ disrupts cellular iron homeostasis, which may contribute to Pb 2+ ‐induced apoptosis in the cerebral cortex (Wang et al, ). Recently, several authors identified neurotoxic effects of lead, such as a change in protein phosphorylation (Bihaqi et al, ) and dephosphorylation, interference in miRNA expression (An et al, ), modulation of interleukin expression (Seddik et al, ; Li et al, ), and oxidative damage (Farina et al, ; Sanders et al, 2014). In the cell membrane, Pb 2+ causes peroxidative damage to lipids and proteins via a combination of mechanisms, such as the release of iron, as well as the disruption of direct pro‐ and antioxidant mechanisms of Pb 2+ (Adonaylo and Oteiza, ; Villeda‐Hernandez et al, ; Farina et al, ).…”

Section: Introductionmentioning

confidence: 99%

Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

et al. 2016

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The objective of this study was to evaluate markers of oxidative stress in the brains of rats exposed to lead acetate (Pb(C H O ) ), either associated or not associated with ferrous sulfate (FeSO ). A total of 36 weaning rats (Rattus norvegicus) were divided into 6 groups of six animals and exposed to lead acetate for six weeks. In the control group (control), the animals received deionized water. The Pb260 and Pb260 + Fe received 260 µM lead acetate, and the Pb1050 and Pb1050 + Fe received 1050 µM lead acetate. The Pb260 + Fe and Pb1050 + Fe were supplemented with 20 mg of ferrous sulfate/Kg body weight every 2 days. Group Fe received deionized water and ferrous sulfate. The rat brains were collected to analyze the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the concentration of reduced glutathione (GSH), lipid peroxidation (TBARS), and total antioxidant substance (TAS) (DPPH technique). The activity of SOD and GPx in the experimental groups decreased compared to the control, together with the concentration of GSH (p < 0.05). For CAT analysis, SOD tended to increase in concentration in the experimental groups without a concomitant exposure to FeSO , whereas GPx showed a slight tendency to increase in activity compared to the control. For TAS-DPPH , there was a decrease in the experimental groups (p < 0.05). According to the results, SOD, GPx, and GSH were affected by lead acetate and exposure to ferrous sulfate changed this dynamic. However, further studies are needed to verify whether ferrous sulfate acts as a protectant against the toxic effects of lead. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 813-822, 2017.

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“…Olive leaves contain many bioactive compounds that have antioxidant, anti-microbial, antihypertensive, anti-viral, anti-inflammatory, hypoglycemic, neuroprotective, and anti-cancer properties (Kontogianni and Gerothanassis, 2012;Pereira et al, 2007;Somova et al, 2003;Micol et al, 2005;Wainstein et al, 2012;Seddik et al, 2011;Bouallagui et al, 2011). Olive leaf extract and compounds, such as apigenin 7-glucoside, showed anti-leukemia effects by inducing the differentiation of different leukemia cell lines (Abaza et al, 2007;Samet et al, 2014a;Tsolmon et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage

et al. 2015

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The generation of blood cellular components from hematopoietic stem cells is important for the therapy of a broad spectrum of hematological disorders. In recent years, several lines of evidence suggested that certain nutrients, vitamins and flavonoids may have important roles in controlling the stem cell fate decision by maintaining their self-renewal or stimulating the lineage-specific differentiation. In this study, main olive leaf phytochemicals oleuropein (Olp), apigenin 7-glucoside (Api7G) and luteolin 7-glucoside (Lut7G) were investigated for their potential effects on hematopoietic stem cell differentiation using both phenotypic and molecular analysis. Oleuropein and the combination of the three compounds enhanced the differentiation of CD34+ cells into myelomonocytic cells and lymphocytes progenitors and inhibited the commitment to megakaryocytic and erythroid lineages. Treatment with Lut7G stimulated both the erythroid and the myeloid differentiation, while treatment with Api7G specifically induced the differentiation of CD34+ cells towards the erythroid lineage and inhibited the myeloid differentiation. Erythroid differentiation induced by Api7G and Lut7G treatments was confirmed by the increase in hemoglobin genes expressions (α-hemoglobin, β-hemoglobin and γ-hemoglobin) and erythroid transcription factor GATA1 expression. As revealed by microarray analysis, the mechanisms underlying the erythroid differentiation-inducing effect of Api7G on hematopoietic stem cells involves the activation of JAK/STAT signaling pathway. These findings prove the differentiation-inducing effects of olive leaf compounds on hematopoietic stem cells and highlight their potential use in the ex vivo generation of blood cells.

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Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats

Cited by 38 publications

References 55 publications

Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Olive leaf extract decreases age-induced oxidative stress in major organs of aged rats

Influence of iron on modulation of the antioxidant system in rat brains exposed to lead

Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage

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