Inertial microfluidics: A method for fast prediction of focusing pattern of particles in the cross section of the channel

Mashhadian, Ali; Shamloo, Amir

doi:10.1016/j.aca.2019.06.057

Cited by 48 publications

(26 citation statements)

References 55 publications

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“…The physics of inertial microfluidics in channels with rectangular cross-sections is more complicated compared to tubular flows. Liu et al 38 and Mashhadian and Shamloo 53 investigated the migration of particles in a straight channel with a rectangular cross-section using the FSPP method. Particle migration in this channel can be divided into two steps.…”

Section: Straight Channelsmentioning

confidence: 99%

Computational inertial microfluidics: a review

et al. 2020

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Section: Straight Channelsmentioning

confidence: 99%

Computational inertial microfluidics: a review

et al. 2020

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“…Scientific RepoRtS |(2020) 10:5929 | https://doi.org/10.1038/s41598-020-62569-9www.nature.com/scientificreports www.nature.com/scientificreports/ flow rates, this equilibrium position increases to three points which are captured using MDA-MB-231 cancer cells inside the channel(Fig. 4DIII)14,53,55 . Surface profilometry of the channel cross sections (rectangular and triangular)(Fig.…”

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confidence: 97%

3D Printing of Inertial Microfluidic Devices

Bazaz

Rouhi

Raoufi

et al. 2020

Sci Rep

143

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Inertial microfluidics has been broadly investigated, resulting in the development of various applications, mainly for particle or cell separation. Lateral migrations of these particles within a microchannel strictly depend on the channel design and its cross-section. Nonetheless, the fabrication of these microchannels is a continuous challenging issue for the microfluidic community, where the most studied channel cross-sections are limited to only rectangular and more recently trapezoidal microchannels. As a result, a huge amount of potential remains intact for other geometries with cross-sections difficult to fabricate with standard microfabrication techniques. In this study, by leveraging on benefits of additive manufacturing, we have proposed a new method for the fabrication of inertial microfluidic devices. In our proposed workflow, parts are first printed via a high-resolution DLP/SLA 3D printer and then bonded to a transparent PMMA sheet using a double-coated pressure-sensitive adhesive tape. Using this method, we have fabricated and tested a plethora of existing inertial microfluidic devices, whether in a single or multiplexed manner, such as straight, spiral, serpentine, curvilinear, and contraction-expansion arrays. Our characterizations using both particles and cells revealed that the produced chips could withstand a pressure up to 150 psi with minimum interference of the tape to the total functionality of the device and viability of cells. As a showcase of the versatility of our method, we have proposed a new spiral microchannel with right-angled triangular cross-section which is technically impossible to fabricate using the standard lithography. We are of the opinion that the method proposed in this study will open the door for more complex geometries with the bespoke passive internal flow. Furthermore, the proposed fabrication workflow can be adopted at the production level, enabling large-scale manufacturing of inertial microfluidic devices.

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“…Further works have demonstrated the same particles’ focusing effect also in straight, non-circular cross-section micro-channels, e.g., square (Figure 1b) [67], rectangular (Figure 1c) [68], triangular [69], non-conventional shape [70] and gradually changing geometrical structures [38], providing also numerical methods for the fast prediction of the focusing patterns of particles along the channels’ cross section [71,72]. Several experimental results on curved [73], serpentine [74] and spiral [55] micro-channels are also reported.…”

Section: Inertial Focusing and Laminar Vortex Technologymentioning

confidence: 99%

Sorting of Particles Using Inertial Focusing and Laminar Vortex Technology: A Review

2019

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The capability of isolating and sorting specific types of cells is crucial in life science, particularly for the early diagnosis of lethal diseases and monitoring of medical treatments. Among all the micro-fluidics techniques for cell sorting, inertial focusing combined with the laminar vortex technology is a powerful method to isolate cells from flowing samples in an efficient manner. This label-free method does not require any external force to be applied, and allows high throughput and continuous sample separation, thus offering a high filtration efficiency over a wide range of particle sizes. Although rather recent, this technology and its applications are rapidly growing, thanks to the development of new chip designs, the employment of new materials and microfabrication technologies. In this review, a comprehensive overview is provided on the most relevant works which employ inertial focusing and laminar vortex technology to sort particles. After briefly summarizing the other cells sorting techniques, highlighting their limitations, the physical mechanisms involved in particle trapping and sorting are described. Then, the materials and microfabrication methods used to implement this technology on miniaturized devices are illustrated. The most relevant evolution steps in the chips design are discussed, and their performances critically analyzed to suggest future developments of this technology.

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Inertial microfluidics: A method for fast prediction of focusing pattern of particles in the cross section of the channel

Cited by 48 publications

References 55 publications

Computational inertial microfluidics: a review

Computational inertial microfluidics: a review

3D Printing of Inertial Microfluidic Devices

Sorting of Particles Using Inertial Focusing and Laminar Vortex Technology: A Review

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