As a consequence of global value chains (GVCs), the exchange rate and its volatility become more important in influencing the output of a country. An interesting question has surfaced that concerns the alteration of exchange rate effects toward output in the GVC context. This study tries to fill the research gap from previous studies to include research that directly examines the impact of participation in GVCs on output in a region with similar exchange rate schemes. This study aims to investigate the relationship of the exchange rate and its volatility on output, and also explores the impact of GVC participation on output. We employ panel data that covers five countries in Asia, including Indonesia, Thailand, Japan, South Korea, and Malaysia, with annual data series through 1990-2015. The analytical method used in this study is the econometric approach with system generalized method of moment (SYS-GMM) approach. The result reveals that, first; the exchange rate volatility has a negative relationship to output; second, the exchange rate appreciation is found to increase output significantly; and third, an increase in GVC participation significantly leads to increased output. Therefore, the impact of exchange rate on output depends very much on the GVC pattern in respective country.