Industrialization of lipid nanoparticles: From laboratory-scale to large-scale production line

Hu, Caibiao; Qian, Airui; Wang, Qiang; Xu, Feng; He, Yi; Xu, Jing; Xia, Yongchang; Xia, Qiang

doi:10.1016/j.ejpb.2016.10.018

Cited by 37 publications

(23 citation statements)

References 25 publications

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“…It provides an effective, reliable means of preparing SLNs and NLCs on a large-scale. For example, this method was used to prepare stavudine-loaded SLNs at batch sizes of up to 60 kg [ 48 ] and coenzyme Q10 loaded-NLCs at a throughput of 25 kg/h [ 49 ]. Initially, coarse lipid particles are prepared and then forced through a homogenizer with a narrow gap of few microns at high pressure [ 29 ].…”

Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

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Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

2020

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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

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Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

“…This homogenization process is cycled until the desired droplet size and uniformity is obtained. The advantages of HPH are short production times, ease of production, organic solvent-free operation, and scale-up feasibility [ 1 , 49 ].…”

Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

2020

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“…These are the limitations of most techniques which were developed for lab-scale production. The potential of high-pressure homogenization and the microemulsion method for manufacturing scale-up has been demonstrated [24,25]. The standard method for NLC fabrication using combination technologies consists of high-shear or high-speed homogenization employed in the pre-emulsion step followed by HPH or emulsification sonication [23,25,26].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial Lipid-Based Carrier for Non-Invasive Capsaicin Delivery; Manufacturing Scale-Up and Human Irritation Assessment

et al. 2020

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Capsaicin is an active compound in chili peppers (Capsicum chinense) that has been approved for chronic pain treatment. The topical application of high-strength capsaicin has been proven to reduce pain; however, skin irritation is a major drawback. The aim of this study was to investigate an appropriate and scalable technique for preparing nanostructured lipid carriers (NLCs) containing 0.25% capsaicin from capsicum oleoresin (NLC_C) and to evaluate the irritation of human skin by chili-extract-loaded NLCs incorporated in a gel formulation (Gel NLC_C). High-shear homogenization with high intensity (10,000 rpm) was selected to create uniform nanoparticles with a size range from 106 to 156 nm. Both the NLC_C and Gel NLC_C formulations expressed greater physical and chemical stabilities than the free chili formulation. Release and porcine biopsy studies revealed the sustained drug release and significant permeation of the NLCs through the outer skin layer, distributing in the dermis better than the free compounds. Finally, the alleviation of irritation and the decrease in uncomfortable feelings following the application of the Gel NLC_C formulation were compared to the effects from a chili gel and a commercial product in thirty healthy volunteers. The chili-extract-loaded NLCs were shown to be applicable for the transdermal delivery of capsaicin whilst minimizing skin irritation, the major noncompliance cause of patients.

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“…[21] There are many successful laboratory trials and industrial applications of this high-energy technology in various food emulsions since its first utilization in 1950s. [21] There are many successful laboratory trials and industrial applications of this high-energy technology in various food emulsions since its first utilization in 1950s.…”

Section: Introductionmentioning

confidence: 99%

“…High pressure homogenization technology is capable of generating intense cavitations, turbulence, and hydraulic shear forces that break up large oil droplets, which finally increases the surface activity of the emulsifying molecules and leads to the formation of small oil droplets . There are many successful laboratory trials and industrial applications of this high‐energy technology in various food emulsions since its first utilization in 1950s .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity, In Vitro Digestibility and Stability of Flaxseed Oil and Quercetin Co‐Loaded Submicron Emulsions

Huang

Wang

Sun

et al. 2018

Euro J Lipid Sci & Tech

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Flaxseed oil and quercetin have received extensive attention in food industry. However, their poor solubility in water and stability are major limitations for their application in functional foods. In this work, we encapsulated flaxseed oil and quercetin into submicron emulsions by high pressure homogenization method to overcome their shortcomings in application. The loading of flaxseed oil in submicron emulsions was 10% and the solubility of quercetin in water is increased by at least 1300 folds. In vitro antioxidant study indicated that the addition of flaxseed oil could increase the antioxidant activity of quercetin. During in vitro digestion, the smaller the particle size of submicron emulsions, the faster the digestive rate of flaxseed oil and the higher the bio‐accessibility of quercetin. Furthermore, accelerated oxidation study revealed that quercetin could protect flaxseed oil effectively. Besides, metallic ions stability study illustrated that the influence of Na+ on the emulsion stability is smaller than that of Ca2+ and high Ca2+ concentration could lead to stratification of the submicron emulsions. The storage stability shows that the prepared submicron emulsions can be stored for 8 weeks at three different temperatures. Hence, submicron emulsion can be a promising vehicle for delivery of flaxseed oil and quercetin. Practical Applications: Submicron emulsions can be used to improve the water solubility and bioavailability of lipophilic nutrients. The combination of flaxseed oil and quercetin in submicron emulsions can compensate for their individual shortcomings in application and exert synergistic beneficial actions on human health. Furthermore, this technology is easy in operation and can be realized in industry. Flaxseed oil and quercetin co‐loaded submicron emulsions can be applied in milk and liquid beverages in food industry. Submicron emulsions are fabricated to enhance the delivery of flaxseed oil and quercetin. The smaller the particle size of submicron emulsions, the faster the digestive rate of flaxseed oil and the higher the bio‐accessibility of quercetin. Quercetin can protect flaxseed oil against oxidation effectively. The antioxidant effect of quercetin is found to be better than commonly used antioxidants.

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Industrialization of lipid nanoparticles: From laboratory-scale to large-scale production line

Cited by 37 publications

References 25 publications

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Nanomaterial Lipid-Based Carrier for Non-Invasive Capsaicin Delivery; Manufacturing Scale-Up and Human Irritation Assessment

Antioxidant Activity, In Vitro Digestibility and Stability of Flaxseed Oil and Quercetin Co‐Loaded Submicron Emulsions

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