Industrial Hygiene Chemistry:  Keeping Pace with Rapid Change in the Workplace

Draper, William M.; Ashley, Kevin; Glowacki, Clifford R.; Michael, Paul R.

doi:10.1021/a19900058

Cited by 18 publications

(4 citation statements)

References 286 publications

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“…2 Tens of thousands of individuals are exposed to metal-containing PM in their workplace, yet relatively few are routinely monitored for their exposure due to the time-intensive sampling and cost-prohibitive analytical methods currently available. 3 Common measurement methods for metals include inductively coupled plasma optical emission spectroscopy, mass spectrometry, and atomic absorption spectroscopy. 4, 5 These analytic methods have high precision, sensitivity, and low detection limits, but they are expensive (> $100 per sample) and require trained specialists for operation.…”

Section: Introductionmentioning

confidence: 99%

Multiplexed paper analytical device for quantification of metals using distance-based detection

et al. 2015

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Exposure to metal-containing aerosols has been linked with adverse health outcomes for almost every organ in the human body. Commercially available techniques for quantifying particulate metals are time-intensive, laborious, and expensive; often sample analysis exceeds $100. We report a simple technique, based upon a distance-based detection motif, for quantifying metal concentrations of Ni, Cu, and Fe in airborne particulate matter using microfluidic paper-based analytical devices. Paper substrates are used to create sensors that are self-contained, self-timing, and require only a drop of sample for operation. Unlike other colorimetric approaches in paper microfluidics that rely on optical instrumentation for analysis, with distance-based detection, analyte is quantified visually based on the distance of a colorimetric reaction, similar to reading temperature on a thermometer. To demonstrate the effectiveness of this approach, Ni, Cu, and Fe were measured individually in single-channel devices; detection limits as low as 0.1, 0.1, and 0.05 µg were reported for Ni, Cu, and Fe. Multiplexed analysis of all three metals was achieved with detection limits of 1, 5, and 1 µg for Ni, Cu, and Fe. We also extended the dynamic range for multi-analyte detection by printing concentration gradients of colorimetric reagents using an off the shelf inkjet printer. Analyte selectivity was demonstrated for common interferences. To demonstrate utility of the method, Ni, Cu, and Fe were measured from samples of certified welding fume; levels measured with paper sensors matched known values determined gravimetrically.

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Section: Introductionmentioning

confidence: 99%

Multiplexed paper analytical device for quantification of metals using distance-based detection

et al. 2015

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“…One of the most promising techniques for ultra-trace multi-element analysis is inductively coupled plasma mass spectrometry (ICP-MS), which is becoming more widely used in the occupational health field. [9][10][11] To address the need for harmonized ICP-MS methods for use by occupational hygiene laboratories, international voluntary consensus standard ICP-MS test methods have been recently developed and promulgated by ASTM International 12 and the International Organization for Standardization (ISO). 13 These consensus standard methods describe aspects of sampling and sample preparation as well as analysis by ICP-MS.…”

Section: Introductionmentioning

confidence: 99%

Interlaboratory evaluation of trace element determination in workplace air filter samples by inductively coupled plasma mass spectrometry

et al. 2012

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Inductively coupled plasma mass spectrometry (ICP-MS) is becoming more widely used for trace elemental analysis in the occupational hygiene field, and consequently new ICP-MS international standard procedures have been promulgated by ASTM International and ISO. However, there is a dearth of interlaboratory performance data for this analytical methodology. In an effort to fill this data void, an interlaboratory evaluation of ICP-MS for determining trace elements in workplace air samples was conducted, towards fulfillment of method validation requirements for international voluntary consensus standard test methods. The study was performed in accordance with applicable statistical procedures for investigating interlaboratory precision. The evaluation was carried out using certified 37-mm diameter mixed-cellulose ester (MCE) filters that were fortified with 21 elements of concern in occupational hygiene. Elements were spiked at levels ranging from 0.025 to 10 μg filter −1 , with three different filter loadings denoted "Low", "Medium" and "High". Participating laboratories were recruited from a pool of over fifty invitees; ultimately twenty laboratories from Europe, North America and Asia submitted results. Triplicates of each certified filter with elemental contents at three different levels, plus media blanks spiked with reagent, were conveyed to each volunteer laboratory. Each participant was also provided a copy of the test method which each participant was asked to follow; spiking levels were unknown to the participants. The laboratories were requested to prepare the filters by one of three sample preparation procedures, i.e., hotplate digestion, microwave digestion or hot block extraction, HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript which were described in the test method. Participants were then asked to analyze aliquots of the prepared samples by ICP-MS, and to report their data in units of μg filter −1 . Most interlaboratory precision estimates were acceptable for medium-and high-level spikes (RSD <25%), but generally yielded greater uncertainties than were anticipated at the outset of the study.

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“…During the last several years, a few research groups have been exploring different methodologies of manufacturing nanometer-sized disks, bands, cones and arrays of ultramicroelectrodes. Developments in the design and fabrication of ultramicroelectrodes offer considerable promises for advances in electrochemical sensors, being specially useful for environmental monitoring purposes (Draper et al, 1999). Another advantage of ultramicroelectrodes is that oftentimes no supporting electrolyte is necessary, owing to the favorable mass-transfer characteristics of tiny electrodes.…”

Section: Micro and Nanostructured Materials In Electrochemical Sensormentioning

confidence: 99%

New Materials in Electochemical Sensors for Pesticides Monitoring

Goicolea¹,

Gómez‐Caballero²,

Barrio³

2011

Pesticides - Strategies for Pesticides Analysis

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Industrial Hygiene Chemistry: Keeping Pace with Rapid Change in the Workplace

Cited by 18 publications

References 286 publications

Multiplexed paper analytical device for quantification of metals using distance-based detection

Multiplexed paper analytical device for quantification of metals using distance-based detection

Interlaboratory evaluation of trace element determination in workplace air filter samples by inductively coupled plasma mass spectrometry

New Materials in Electochemical Sensors for Pesticides Monitoring

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