Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

Tan, Ming Jen; Wu, Wenjun; Xu, Xiumin; Liao, Lianming; Zhao, Feng; Messinger, Shari; Sun, Xinhui; Jin, Chen; Yang, Shaodong; Cai, Jinquan; Gao, Xia; Pileggi, Antonello; Ricordi, Camillo

doi:10.1001/jama.2012.316

Cited by 496 publications

(412 citation statements)

References 39 publications

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“…Graft survival was similar, but MSC infusion resulted in fewer acute rejections at 6 months, no corticosteroid-resistant rejection, accelerated renal function recovery, and a reduced rate of opportunistic infections. How ever, acute rejection rates and glomerular filtration rates were not different at 1 year postransplant [42].…”

Section: Human Studiesmentioning

confidence: 84%

The use of mesenchymal stromal cells in solid organ transplantation

Delens

Jouret

Detry

et al. 2016

The Biology and Therapeutic Application of Mesenchymal Cells

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Section: Human Studiesmentioning

confidence: 84%

The use of mesenchymal stromal cells in solid organ transplantation

Delens

Jouret

Detry

et al. 2016

The Biology and Therapeutic Application of Mesenchymal Cells

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“…It is used as a new stem cell therapy for autoimmune diseases, solid organ transplantation, and treatment of graft-versus-host disease (13)(14)(15). For reducing ACR, BMSC treatment was used in three patients.…”

Section: Discussionmentioning

confidence: 99%

Pediatric small bowel transplantation: A single-center experience from Turkey

Tuğmen¹,

Baran²,

Sert³

et al. 2016

Turk J Gastroenterol

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“…These studies are mainly feasibility and safety studies on adult recipients from LD. Only one study has been performed to assess the efficacy of these stem cell injections [89] compared to anti-interleukin-2 receptor antibodies. The authors of this study concluded that autologous mesenchymal stem cell injection results in a lower incidence of acute rejection, a decreased risk of opportunistic infection and better regulated renal function at 1 year.…”

Section: Strategies To Limit Renal Ischemia-reperfusion Injuries and mentioning

confidence: 99%

Strategies to optimize kidney recovery and preservation in transplantation: specific aspects in pediatric transplantation

et al. 2014

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In renal transplantation, live donor kidney grafts are associated with optimum success rates due to the shorter period of ischemia during the surgical procedure. The current shortage of donor organs for adult patients has caused a shift towards deceased donors, often with co-morbidity factors, whose organs are more sensitive to ischemia-reperfusion injury, which is unavoidable during transplantation. Donor management is pivotal to kidney graft survival through the control of the ischemiareperfusion sequence, which is known to stimulate numerous deleterious or regenerative pathways. Although the key role of endothelial cells has been established, the complexity of the injury, associated with stimulation of different cell signaling pathways, such as unfolded protein response and cell death, prevents the definition of a unique therapeutic target. Preclinical transplant models in large animals are necessary to establish relationships and kinetics and have already contributed to the improvement of organ preservation. Therapeutic strategies using mesenchymal stem cells to induce allograft tolerance are promising advances in the treatment of the pediatric recipient in terms of reducing/withdrawing immunosuppressive therapy. In this review we focus on the different donor management strategies in kidney graft conditioning and on graft preservation consequences by highlighting the role of endothelial cells. We also propose strategies for preventing ischemia-reperfusion, such as cell therapy.

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Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

Cited by 496 publications

References 39 publications

The use of mesenchymal stromal cells in solid organ transplantation

The use of mesenchymal stromal cells in solid organ transplantation

Pediatric small bowel transplantation: A single-center experience from Turkey

Strategies to optimize kidney recovery and preservation in transplantation: specific aspects in pediatric transplantation

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