Induction of tumoricidal activity of human and murine peritoneal macrophages by antitumor chemotherapy

Patapov, S. L.; Vyadro, M. M.

doi:10.1007/bf00839474

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“…2, b). An increase in the phagocytic activity of peritoneal macrophages in mice immunized with sheep erythrocytes on days 4 and 30 after CP (in comparison with intact controls) during the first month of experiment is in line with the published reports [9].…”

Section: Resultssupporting

confidence: 89%

Reactions of the immune and hemopoietic systems to antigenic stimulation in the cytostatic disease

Masnaya

Ratner

1998

Bull Exp Biol Med

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A single intraperitoneal injection of cyclophosphamide in the maximum tolerated dose to male CBA mice followed by immunization with thymus-dependent antigen suppressed the humoral immunity reactions (the number of antibody-producing splenocytes and their functional activity) and hematological parameters at the early stages of the cytostatic disease, this suppression persisting at the late stages of the disease. Key Words: cyclophosphamide; antibody-producing cells; IgM, IgG antibodies; peritoneal macrophages; lymphoid organs; peripheral bloodCytostatic drugs are toxic for tumor cells and for normal cells capable of active proliferation and differentiation or blastogenesis [2,3,6,7]. Disorders in animal and human organs and systems occur both at the early and remote periods after antitumor drug injection [5,12]. We compared the reactions of the immune and hemopoietic systems of mice after injection of the antigen at the early stages of the cytostatic disease (CD) caused by a single dose of the alkylating compound cyclophosphamide (CP). MATERIALS AND METHODSExperiments were carried out on 230 male CBA mice weighing 16-33 g (Rassvet Breeding Center). The cytostatic disease was induced by CP (Biokhimik, Saransk)/The drug was injected intraperitoneally in a single maximum tolerated dose (250 mg/kg) which was determined by graphical probit analysis [111.Experimental mice were immunized by corpuscular thymus-dependent antigen in a single dose of 0.2 ml 15% sheep erythrocyte suspension intraperi-

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Section: Resultssupporting

confidence: 89%