Abstract:A single intraperitoneal injection of cyclophosphamide in the maximum tolerated dose to male CBA mice followed by immunization with thymus-dependent antigen suppressed the humoral immunity reactions (the number of antibody-producing splenocytes and their functional activity) and hematological parameters at the early stages of the cytostatic disease, this suppression persisting at the late stages of the disease.
Key Words: cyclophosphamide; antibody-producing cells; IgM, IgG antibodies; peritoneal macrophages; … Show more
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