Induction of the hepatic microsomal and nuclear cytochrome P-450 system by hexachlorobenzene, pentachlorophenol and trichlorophenol

Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

“…PCP is known as an uncoupler of mitochondrial oxidative phosphorylation and can disturb liver microsomal detoxification functions, including that of CYP450 (Arrhenius et al, 1977). The induction of CYP450 by PCP in humans and animals has been studied both in vivo and in vitro (Barque et al, 2002;Dubois et al, 1997;Vizethum and Goerz, 1979). Alkoxyresorufin O-dealkylase (AROD) activities, including EROD, MROD and BROD activities, are typical catalytic markers for a variety of CYP450 enzymes, and thus have great potential to elucidate CYP450 induction by chemical exposure.…”

Organochlorine Chemical Residues in Fish from the Mississippi River Basin, 1995

“…Environmental residues occur from the use of HCB a fungicide (Vizethum and Goerz 1979) and because HCB is a by-product of the production of other chlorinated hydrocarbons (Villanueva et al 1974). HCB is shorter-lived (Villanueva et al 1974) and much less toxic (Jarvinen and Ankley 1999) than DDT and most other persistent organochlorine compounds; however, commercial formulations once contained toxic impurities, including polychlorinated dibenzo-pdioxins and -dibenzofurans (Villanueva et al 1974).…”

Pentachlorophenol potentiates benzo[a]pyrene DNA adduct formation in adult but not infant B6C3F1 male mice†

“…Because 8-OHdG was not observed in infants or adult mice, it is possible that PCP was not metabolized to Cl 4 -1,2-Q or Cl 4 -1,4-Q. A possible mechanism to explain the potentiating effects observed from exposure to the binary mixture of B[a]P and PCP in adults could be stimulation of CYP1A1 [Vizethum and Goerz, 1979]. This would result in increased metabolism of B[a]P to epoxide intermediates that bind to DNA.…”