Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice

Maskey, Anish; Soffer, Gary; Dunkin, David; Yuan, Qian; Li, Xiumin

doi:10.2147/jir.s372449

Cited by 3 publications

(2 citation statements)

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“…Recently, a causal relationship between oral immunotherapy (OIT) to food allergens and the development of EoE has also been proven. A role for inhaled allergens in both the onset and exacerbation of EoE seems less certain but possible, as suggested by a study that showed an association between pollen season and the incidence of diagnosis and the timing of EoE exacerbations [7]. The development and exacerbation of EoE by inhaled allergens through a cross-reactivity mechanism with food allergens is also thought to be potentially possible [7].…”

Section: Eosinophilic Oesophagitis -Aetiologymentioning

confidence: 99%

“…A role for inhaled allergens in both the onset and exacerbation of EoE seems less certain but possible, as suggested by a study that showed an association between pollen season and the incidence of diagnosis and the timing of EoE exacerbations [7]. The development and exacerbation of EoE by inhaled allergens through a cross-reactivity mechanism with food allergens is also thought to be potentially possible [7]. Recent studies have also increasingly suggested the possibility of EoE following sublingual immunotherapy for respiratory allergies.…”

Section: Eosinophilic Oesophagitis -Aetiologymentioning

confidence: 99%

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Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis

Kuźmiński,

Przybyszewska,

Bartuzi

2024

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Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease, clinically characterised by symptoms of esophageal dysfunction and histologically by eosinophilic infiltration of its wall. The last 3 decades have seen a sharp increase in its incidence to the point that it is called the second most common esophageal disease after reflux disease in some recent studies. The main indicators of EoE are food allergens and in recent years the extremely important role of oral immunotherapy (OIT) in the development of this disease has also been increasingly raised. To date, the appearance of EoE in the course of OIT is an absolute indication for discontinuation of this procedure; however, other therapeutic options that do not require termination of this procedure are increasingly being advocated. Unfortunately, our knowledge of EoE is full of gaps and requires numerous studies to fill in the missing elements of the pathogenesis and clinic of the described disease.

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Section: Eosinophilic Oesophagitis -Aetiologymentioning

confidence: 99%

Section: Eosinophilic Oesophagitis -Aetiologymentioning

confidence: 99%

Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis

Kuźmiński,

Przybyszewska,

Bartuzi

2024

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Animal models of eosinophilic esophagitis

Pilat,

Jacobse,

Buendia

et al. 2024

Journal of Leukocyte Biology

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Eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus. Over the past 25 yr, great strides have been made toward understanding its pathogenesis, in part due to studies in several types of animal models. The vast majority of these models have been characterized in mice. In this review, we summarize the histopathological features of eosinophilic esophagitis recapitulated by these animal models, as well as discuss their strengths and weaknesses.

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Allergen immunotherapy and eosinophilic esophagitis: friends or foes?

Pitsios,

Rossi

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review The connection between eosinophilic esophagitis (EoE) and food and airborne allergens is complex. Exposure to allergens (mainly food) is often the trigger for EoE flares. The development of EoE has been described as a side effect of allergen immunotherapy, especially oral immunotherapy (OIT, with food allergens), while isolated cases of EoE have been reported during sublingual immunotherapy (SLIT, with extracts of aeroallergens). Recent findings EoE is currently recognized as a common side effect of OIT, while a solid correlation between SLIT and EoE is missing. Animal models have been developed to study the pathophysiological link between sensitization to aeroallergens and the induction of EoE and will probably provide an interpretation of why there are cases of EoE developed during SLIT. Recent findings in animal models suggest a genetic connection to EoE development after sensitization and re-exposure to airborne allergens. Subcutaneous allergen immunotherapy does not have a causative effect on EoE; on the contrary, a beneficial effect on EoE has been reported. Moreover, epicutaneous immunotherapy with a vector containing milk has also been used to treat children with milk-induced EoE. Summary Discovering the immune links between allergens and EoE will further guide the proper use of allergen immunotherapy and help define future strategies for the management of EoE.

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Induction of Severe Eosinophilic Esophagitis and Multi-Organ Inflammation by Airborne Allergens is Associated with IL-4/IL-13 and CCL11 but Not IgE in Genetic Susceptible Mice

Cited by 3 publications

References 57 publications

Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis

Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis

Animal models of eosinophilic esophagitis

Allergen immunotherapy and eosinophilic esophagitis: friends or foes?

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