Induction of reparative dentine formation in monkeys by recombinant human osteogenic Protein-1

Rutherford, R. Bruce; Wahle, J.J.; Tucker, Marjorie; Rueger, David C.; Charette, Marc

doi:10.1016/0003-9969(93)90121-2

Cited by 242 publications

(161 citation statements)

References 16 publications

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“…BMPs have actions beyond bone in neural, renal and cardiac development. 1,2 BMPs also play a role in differentiation of dentin [3][4][5][6][7][8] in teeth. The recent progress in molecular developmental biology permits the delivery of BMPs by gene therapy using optimal delivery.…”

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confidence: 99%

Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11)

et al. 2002

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confidence: 99%

Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11)

et al. 2002

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“…Since post-natal morphogenesis and regeneration recapitulate events that occur in the course of embryonic development, the patterns of expression of different BMPs during embryonic development point to novel strategies of therapeutic intervention outside bone and cartilage regeneration. Indeed, additional in vivo roles of BMPs for functions other than cartilage and bone induction have recently been demonstrated by the induction of dentinogenesis (Nakashima, 1990(Nakashima, , 1994Rutherford et al, 1993b) and cementogenesis during repair and regeneration of periodontal wounds in primates Ripamonti et al, , 1996a.…”

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confidence: 99%

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Ripamonti

Reddi

1997

Critical Reviews in Oral Biology & Medicine

163

129

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Tissue engineering is the emerging field of science developing techniques for fabrication of new tissues for replacement based on principles of cell and developmental biology and biomaterials. Morphogenesis is the cascade of pattern formation and the attainment of form of the various organs and the organism as a whole. The periodontium consists of the periodontal ligament, cementum, and alveolar bone. Bone has considerable potential for regeneration and therefore is a prototypic model for tissue engineering. The three main ingredients for tissue engineering are regulatory signals, responding stem cells, and extracellular matrix. Recent advances in molecular biology of the bone morphogenetic proteins (BMPs) have set the stage for tissue engineering of bone and related tissues, including the periodontium. Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. It is noteworthy that there was morphogenesis of periodontal ligament and a faithful insertion of Sharpey's fibers into cementum. In the same furcation model, recombinant human osteogenic protein-l (rhOP-l, also known as BMP-7), in conjunction with the collagenous carrier, induced extensive cementogenesis with insertion of Sharpey's fibers into the newly formed cementum. The observation that BMPs induce cementogenesis and periodontal ligament formation indicates that these proteins may have multiple functions in vivo not limited to cartilage and bone induction. The rapid advances in the molecular biology of BMPs and their receptors bode well for novel strategies to engineer the regeneration of the periodontal tissues.

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“…Bone morphogenetic protein 7-OP-1-Investigations on the potential role of Bone Morphogenetic Protein 7 (BMP7), also called Osteogenic protein-1 (OP-1) [7,8,[11][12][13] were carried out to analyze the effects of OP-1 in the rat molar model compared with BSP. In the same experimental conditions, in the crown part of the pulp, a porous reparative dentin of the osteodentin type was produced with major fissures due to pulp remnants.…”

Section: Effects Of Ecm Moleculesmentioning

confidence: 99%

Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration

et al. 2007

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This review summarizes the in vivo experiments carried out by our group after implantation of bioactive molecules (matricellular molecules) into the exposed pulp of the first maxillary molar of the rat or the mandibular incisor of rats and mice. We describe the cascade of recruitment, proliferation and terminal differentiation of cells involved in the formation of reparative dentin. Cloned immortalized odontoblast progenitors were also implanted in the incisors and in vitro studies aimed at revealing the signaling pathways leading from undifferentiated progenitors to fully differentiated polarized cells. Together, these experimental approaches pave the way for controlled dentin regenerative processes and repair. NIH Public Access

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Induction of reparative dentine formation in monkeys by recombinant human osteogenic Protein-1

Cited by 242 publications

References 16 publications

Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11)

Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11)

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Matricellular molecules and odontoblast progenitors as tools for dentin repair and regeneration

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