Induction of porphyria in the rat by chronic versus acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXα reductase and δ-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor

“…Guberman et al (2003) suggested that activator protein-1 (AP-1) complex has an inhibitory effect on ALAS1 expression, and TCDD has been shown to induce AP-1 (Puga et al, 2000). It is also noteworthy that the repression of ALAS1 found here after a single exposure to relatively high, even lethal dose (depending on the rat strain) of TCDD is at variance with its induction reported after repeated exposure of Sprague-Dawley rats to a low dose (1 g/kg/week) of TCDD for 16 weeks (Goldstein et al, 1982).…”

“…1). TCDD and some other cytochrome P450 inducers have been shown to increase its activity (Goldstein et al, 1982;Granick, 1966;May et al, 1995;Poland and Glover, 1973). The ultimate goal of this study was to look for such changes in gene/protein expression or enzymatic activity that might be related to the pathogenesis of hepatic biliverdin accumulation.…”

Proteomic Analysis of the Rat Ovary Following Chronic Low-Dose Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)

“…Bruggeman et al (2006) showed the effects of TCDD on the ovary and liver in 1-d-old chickens as evidenced by alterations in proteins that could not be directly linked to drug on xenobiotic metabolism but appeared to be involved in oxidative stress, blood clotting, calcium regulation, and electron transport. Some studies found that the toxicity following chronic exposure was different from acute exposure (Franczak et al, 2006;Goldstein et al,1982). Few studies have addressed the proteomic reactions of ovary tissue following chronic exposure to low doses of TCDD.…”

Environmental Chemical Exposures and Disturbances of Heme Synthesis

“…Unfortunately, there has been only limited systematic study of the subject in humans. In or TCDDs) in high ingested doses are porphyrinogenic in rodents (112,113), but the evidence in humans is mixed. The strongest human evidence is from two workplace studies.…”