Induction of photoreceptor voltage noise in the dark in Drosophila mutant

Minke, Baruch; Wu, Chun‐Fang; Pak, William L.

doi:10.1038/258084a0

Cited by 230 publications

(160 citation statements)

References 13 publications

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“…"trp" stands for "transient receptor potential" (61), which was the first blind fly gene cloned (62). trp and its homolog trpl (trplike) were later shown to encode pore-forming channel subunits (63).…”

Section: The Photomechanics Of Fly Visionmentioning

confidence: 99%

Feeling the hidden mechanical forces in lipid bilayer is an original sense

Anishkin

Loukin²,

Teng³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

249

216

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Life's origin entails enclosing a compartment to hoard material, energy, and information. The envelope necessarily comprises amphipaths, such as prebiotic fatty acids, to partition the two aqueous domains. The self-assembled lipid bilayer comes with a set of properties including its strong anisotropic internal forces that are chemically or physically malleable. Added bilayer stretch can alter force vectors on embedded proteins to effect conformational change. The force-from-lipid principle was demonstrated 25 y ago when stretches opened purified Escherichia coli MscL channels reconstituted into artificial bilayers. This reductionistic exercise has rigorously been recapitulated recently with two vertebrate mechanosensitive K + channels (TREK1 and TRAAK). Membrane stretches have also been known to activate various voltage-, ligand-, or Ca 2+ -gated channels. Careful analyses showed that Kv, the canonical voltage-gated channel, is in fact exquisitely sensitive even to very small tension. In an unexpected context, the canonical transient-receptor-potential channels in the Drosophila eye, long presumed to open by ligand binding, is apparently opened by membrane force due to PIP 2 hydrolysis-induced changes in bilayer strain. Being the intimate medium, lipids govern membrane proteins by physics as well as chemistry. This principle should not be a surprise because it parallels water's paramount role in the structure and function of soluble proteins. Today, overt or covert mechanical forces govern cell biological processes and produce sensations. At the genesis, a bilayer's response to osmotic force is likely among the first senses to deal with the capricious primordial sea. mechanosensitivity | force sensing | channel gating | bilayer mechanics | touch

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Section: The Photomechanics Of Fly Visionmentioning

confidence: 99%

Feeling the hidden mechanical forces in lipid bilayer is an original sense

Anishkin

Loukin²,

Teng³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

249

216

View full text Add to dashboard Cite

show abstract

“…Drosophila trp was originally isolated as a mutant, in which the light response decayed to baseline during prolonged illumination (Cosens and Manning, 1969;Minke et al, 1975). The gene was later cloned and found to encode a novel protein with multiple transmembrane (TM) segments reminiscent of cation channels known at the time (Montell and Rubin, 1989).…”

Section: Introductionmentioning

confidence: 99%

In VivoIdentification and Manipulation of the Ca²⁺Selectivity Filter in theDrosophilaTransient Receptor Potential Channel

et al. 2007

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“…mechanosensitivity ͉ mechanosensor ͉ aromatic residues ͉ single channel T ransient receptor potential (TRP) channels are named after the near-blind mutant flies that show a TRP in their electroretinogram, first examined in the 1960s and 1970s (1)(2)(3). This work, together with the additional discoveries of related channels underlying sensitivity to heat (4) and mechanical forces (5) in 1997, kindled great interest in this class of channels.…”

mentioning

confidence: 99%