Induction of Ovulation and Multiple Ovulations in Seasonally Anovulatory and Ovulatory Mares with an Equine Pituitary Extract

Lapin, D.; Ginther, O.J.

doi:10.2527/jas1977.445834x

Cited by 71 publications

(17 citation statements)

References 10 publications

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“…It is possible that at this stage of development, follicles display a smaller number of FSH receptors, diminishing treatment potential. One donor on T3 displayed an anovulatory cycle, despite having follicle with a diameter of 50 mm during a period of ten days, similar to previous reports (Dippert et al 1994, Lapin andGinther 1997).…”

Section: Discussionsupporting

confidence: 88%

Induction of multiple ovulations in mares using low doses of GnRH agonist Deslorelin Acetate at 48 hours after luteolysis

Azevedo¹,

Souza²,

Ferreira-Silva³

et al. 2015

PHK

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Summary: This study was aimed to test low doses of a GnRH agonist, deslorelin acetate (DA), for induction of multiple ovulations in mares and to determine its impact upon their reproductive efficiency. Seven mares aging from 8 -20 years were used in three consecutive reproductive cycles. Mares were initially monitored by ultrasound irrespectively of cycle stage, inseminated and submitted to embryo collection (EC) (T1). Immediately after, mares received 7.5 mg dinoprost tromothamine (DT) and were monitored by ultrasound twice a day until larger follicle reached 23 -25 mm and the second >18 mm (T2). At this time point, mares received 100 µg DA and ovulation was induced with 1000 µg DA and 1000 IU hCG when largest follicle reached 33 -35 mm in diameter, followed by EC. Mares were further allocated to T3 when received 7.5 mg DT after EC on T2 and 100 µg DA 48 h later. DA treatment was performed until dominant follicle reached 34 ±1 mm or 6 days of application. All EC were performed 8 days after ovulation. Mares with multiple ovulations in T1, T2 and T3 were 14.28 % (1/7), 100.00 % (7/7) and 0.00 % (0/7), respectively, and averaged 0.43 ± 0.53 in T1, 0.86 ± 0.38 in T2 and 0.00 in T3 embryos per donor, respectively. Embryo recovery rate was 43.00 % in T1, 85.71 % in T2 and 0.00 % T3. In conclusion, use of DA in mares with follicles larger than 25mm enhanced dominant and co-dominant follicle growth, that ultimately increased the incidence of multiple ovulations and embryo recovery rate.

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Section: Discussionsupporting

confidence: 88%

Induction of multiple ovulations in mares using low doses of GnRH agonist Deslorelin Acetate at 48 hours after luteolysis

Azevedo¹,

Souza²,

Ferreira-Silva³

et al. 2015

PHK

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“…Thus, as in ewes (Turnbull et al, 1978 ;Cahill and Mauleon, 1980), the only part of folliculogenesis lacking during winter is preovulatory development. Furthermore, anestrous follicles seem to be sensitive to endogenous or exogenous hormones since Oxender, Noden and Hafs (1977) have noticed some spikes of estradiol-17(3, and ovulation has been successfully induced with pituitary extracts in a fortnight in seasonally anovulatory mares (Douglas, Nuti and Ginther, 1974 ;Lapin and Ginther, 1977). Another conclusion that can be drawn from a comparison of group I and III ovaries is the fact that follicular populations less than 10 mm in diameter are relatively independent of the hormonal milieu.…”

mentioning

confidence: 79%

Seasonal effects on ovarian follicular development in pony mares

Driancourt¹,

Prunier²,

Palmer³

et al. 1983

Reprod. Nutr. Dévelop.

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“…Douglas and colleagues [2] induced multiple ovulations in seasonally anovulatory mares using EPE. Further studies in this same laboratory stimulated multiple ovulations in mares during the physiologic breeding season [3]. Numerous other investigators used EPE to induce superovulation in cycling mares [4][5][6][7][8].…”

Section: Historical Backgroundmentioning

confidence: 99%

Superovulation in Mares

Squires

2006

Veterinary Clinics of North America: Equine Practice

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Induction of Ovulation and Multiple Ovulations in Seasonally Anovulatory and Ovulatory Mares with an Equine Pituitary Extract

Cited by 71 publications

References 10 publications

Induction of multiple ovulations in mares using low doses of GnRH agonist Deslorelin Acetate at 48 hours after luteolysis

Induction of multiple ovulations in mares using low doses of GnRH agonist Deslorelin Acetate at 48 hours after luteolysis

Seasonal effects on ovarian follicular development in pony mares

Superovulation in Mares

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