Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders

Takano, Hiroshi; Ariyoshi, Wataru; Kanno, Takeshi; Fukuhara, Eiji; Ichimiya, Hisashi; Matayoshi, Takaaki; Goto, Tetsuya; Takahashi, Tsuneo

doi:10.1016/j.joca.2006.08.001

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…The inflammatory cytokines such as prostaglandins, interleukines and TNF-α are potential regulators of osteoclastogenesis ( 20 ). Increased synovial fluid IL-1ß, IL-6 and TNF-α levels, which are important findings of inflammation, have been frequently addressed in the literature ( 2 , 20 - 22 ). Kaneyama et al .…”

Section: Discussionmentioning

confidence: 99%

Effects of glucosamine-chondroitin combination on synovial fluid IL-1β, IL-6, TNF-α and PGE2 levels in internal derangements of temporomandibular joint

Damlar¹,

Esen²,

Tatlı³

2015

Med Oral

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BackgroundThe aim of the present study was to evaluate the effects of glucosamine-chondroitin sulphate combination on internal derangements of temporomandibular joint in clinical and biochemical manners.Material and MethodsThis randomized clinical study included 31 cases reporting joint tenderness, in which disc displacement was detected on MR imaging. In all patients, synovial fluid sampling was performed under local anesthesia. In the study group, the patients were prescribed a combination of 1500 mg glucosamine and 1200 mg chondroitin sulphate, while patients in the control group were only prescribed 50 mg tramadol HCl (twice daily) for pain control. After 8 weeks, synovial fluid sampling was repeated in the same manner. The levels of pain, maximum mouth opening (MMO), synovial fluid IL-1ß, IL-6, TNF-α and PGE2 measured before and after pharmacological intervention were compared.ResultsThe reduction in pain levels was significant in both groups. There was no significant difference between two groups in terms of pain reduction. The improvement in MMO was significant in the study group but it was not in the control group. The MMO improvement was significantly higher in the study group compared to the control group. In the study group, significant decrease was observed in PGE2 level, while the decreases in IL-1β, IL-6 and TNF-α levels were not significant. In the control group, no significant decrease was observed in any of the inflammatory cytokines after 8 weeks, moreover IL-1ß and IL-6 levels were increased. Alterations of IL-1ß and IL-6 levels were significant in study group while TNF-α and PGE2 levels were not, compared to control group.ConclusionsIn conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1β and IL6 levels in internal derangements of TMJ compared to tramadol. The modifications of synovial fluid TNF-α and PGE2 levels do not reach statistical significance. This combination also provides efficient pain relief in similar level with tramadol, a narcotic analgesic. Key words: Chondroitin sulphate, glucosamine, internal derangement, TMJ, tramadol.

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Section: Discussionmentioning

confidence: 99%

Effects of glucosamine-chondroitin combination on synovial fluid IL-1β, IL-6, TNF-α and PGE2 levels in internal derangements of temporomandibular joint

Damlar¹,

Esen²,

Tatlı³

2015

Med Oral

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“…To determine the number of osteoclasts, femurs were stained with Tartrate-resistant acid phosphatase (TRAP) kit (Sigma) as TRAP is commonly used as a marker of osteoclasts in bone as previously reported (Halleen et al, 1999;Takano et al, 2004Takano et al, , 2006Beeton et al, 2006;Itoh et al, 2006;Ren et al, 2006;Wan et al, 2006). Images were analyzed under bright field microscopy on a Nikon E800 at 4× and 10× magnification.…”

Section: Femora-femoramentioning

confidence: 99%

Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer

King

Vardanyan

Majuta

et al. 2007

Pain

104

100

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Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone destruction is tightly controlled was used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced, rather than diminished, spontaneous, and evoked pain; these effects were dose-dependent and naloxone-sensitive. SP and CGRP positive DRG cells did not differ between sarcoma or control mice, but were increased following morphine in both groups. Morphine increased ATF-3 expression only in DRG cells of sarcoma mice. Morphine did not alter tumor growth in vitro or tumor burden in vivo but accelerated sarcoma-induced bone destruction and doubled the incidence of spontaneous fracture in a dose- and naloxone-sensitive manner. Morphine increased osteoclast activity and upregulated IL-1 beta within the femurs of sarcoma-treated mice suggesting enhancement of sarcoma-induced osteolysis. These results indicate that sustained morphine increases pain, osteolysis, bone loss, and spontaneous fracture, as well as markers of neuronal damage in DRG cells and expression of pro-inflammatory cytokines. Morphine treatment may result in "add-on" mechanisms of pain beyond those engaged by sarcoma alone. While it is not known whether the present findings in this model of osteolytic sarcoma will generalize to other cancers or opioids, the data suggest a need for increased understanding of neurobiological consequences of prolonged opioid exposure which may allow improvements in the use of opiates in the effective management of cancer pain.

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“…3 The presence of varying degrees of inflammation has also been reported in certain TMDs. 4 Vitamin D is an important component in calcium homeostasis, which is known to have a key role in bone health, including articular structures and muscles. 5 Not surprisingly, studies have shown an association between low vitamin D status and musculoskeletal disorders.…”

Section: Introductionmentioning

confidence: 99%

Biochemical changes associated with temporomandibular disorders

Demir

Ersöz

2018

J Int Med Res

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Objective To assess vitamin D, parathyroid hormone, calcitonin, calcium, phosphorus and magnesium levels in patients with versus without temporomandibular disorders (TMDs). Methods This prospective observational study included patients with TMDs and age-matched healthy controls. TMDs were diagnosed via physical and radiologic examination, and serum levels of 25 (OH) vitamin D, parathyroid hormone, calcitonin, calcium, magnesium, and phosphorus were determined. The impact of age, sex and seasonal variations in serum 25 (OH) vitamin D levels was controlled by the inclusion of age, sex and date-matched control patients. Results The study included 100 patients, comprising 50 patients with TMDs and 50 control patients. No statistically significant between-group differences were found regarding age or sex. No statistically significant between-group differences were found in terms of serum 25 (OH) vitamin D, calcitonin, calcium, magnesium or phosphorus levels. Parathyroid hormone levels were statistically significantly higher in patients with TMDs versus healthy control patients. Conclusion In patients with temporomandibular disorders, increased parathyroid hormone levels in response to vitamin D deficiency was significantly more prominent. These data suggest that, in patients with temporomandibular disorders, vitamin D deficiency should be assessed and corrected.

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Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders

Abstract: The results suggest that the joint-infiltrating SF cells from TMD patients play important roles in the pathogenesis of these disorders, which is characterized by progressive bone destruction or remodeling.

Cited by 8 publications

References 38 publications

Effects of glucosamine-chondroitin combination on synovial fluid IL-1β, IL-6, TNF-α and PGE2 levels in internal derangements of temporomandibular joint

Effects of glucosamine-chondroitin combination on synovial fluid IL-1β, IL-6, TNF-α and PGE2 levels in internal derangements of temporomandibular joint

Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer

Biochemical changes associated with temporomandibular disorders

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