Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin

Ercan, Sevim; Kencebay, Ceren; Basaranlar, Goksun; Özcan, Filiz; Derın, Narin; Aslan, Mutay

doi:10.1186/s12944-015-0008-3

Cited by 9 publications

(4 citation statements)

References 44 publications

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“…Notably, ghrelin exhibited protective effects on Caco-2 cell apoptosis in a dose-dependent manner, consistent with the protective effects of ghrelin reported in a previous study ( Ercan et al, 2015 ). However, ghrelin had no significant effects on Caco-2 cell apoptosis at both dosage of 0.01 μmol/L and a higher dose of 10 μmol/L.…”

Section: Discussionsupporting

confidence: 91%

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis

et al. 2021

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Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that occurs in the lining of the rectum and colon. Apoptosis of the intestinal epithelial cells (IECs) is common in active UC patients. Ghrelin is reported to be downregulated in apoptosis of IECs induced by tumor necrosis factor-α (TNF-α). Therefore, we hypothesized that ghrelin might play an antiapoptotic role in UC progression, which was investigated using in vitro and in vivo studies. The TNF-α-treated Caco-2 cell model and mouse colitis model induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzenesulfonic acid (TNBS) were established and employed. We found that ghrelin could inhibit the apoptosis of Caco-2 cells induced by TNF-α, which could be disturbed by [D-lys3]-GHRP-6, the antagonist of ghrelin receptor GHS-R1a. Similarly, in the DSS- and TNBS-induced mouse colitis models, ghrelin could also protect intestinal tissues from apoptosis in DSS- and TNBS-induced colitis depending on GHS-R1a. Furthermore, ghrelin modulated the unfolded protein response (UPR) pathway and regulated the expressions of caspase-3, BAX, and Bcl-2, which contributed to the inhibition of cell apoptosis. In conclusion, ghrelin protects IECs from apoptosis during the pathogenesis of colitis by regulating the UPR pathway.

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Section: Discussionsupporting

confidence: 91%

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis

et al. 2021

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“…Ghrelin also causes an anti-inflammatory action through modulation of n-6 polyunsaturated fatty acid (PUFA) inflammatory pathways in liver tissue. In sodium metabisulfite-treated rats, ghrelin treatment reduced n-6 PUFA, COX, and PGE2 levels in the liver [ 180 ].…”

Section: The Effects Of Ghrelin System On the Hepatic Inflammationmentioning

confidence: 99%

Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers

Kasprzak

Adamek

2022

IJMS

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It is not known exactly what leads to the development of colorectal cancer (CRC) and hepatocellular carcinoma (HCC), but there are specific risk factors that increase the probability of their occurrence. The unclear pathogenesis, too-late diagnosis, poor prognosis as a result of high recurrence and metastasis rates, and repeatedly ineffective therapy of both cancers continue to challenge both basic science and practical medicine. The ghrelin system, which is comprised of ghrelin and alternative peptides (e.g., obestatin), growth hormone secretagogue receptors (GHS-Rs), and ghrelin-O-acyl-transferase (GOAT), plays an important role in the physiology and pathology of the gastrointestinal (GI) tract. It promotes various physiological effects, including energy metabolism and amelioration of inflammation. The ghrelin system plays a role in the pathogenesis of inflammatory bowel diseases (IBDs), which are well known risk factors for the development of CRC, as well as inflammatory liver diseases which can trigger the development of HCC. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Little is known about the role of the ghrelin system in the mechanisms of transformation of chronic inflammation to low- and high-grade dysplasia, and, finally, to CRC. HCC is also associated with chronic inflammation and fibrosis arising from different etiologies, including alcoholic and nonalcoholic fatty liver diseases (NAFLD), and/or hepatitis B (HBV) and hepatitis C virus (HCV) infections. However, the exact role of ghrelin in the progression of the chronic inflammatory lesions into HCC is still unknown. The aim of this review is to summarize findings on the role of the ghrelin system in inflammatory bowel and liver diseases in order to better understand the impact of this system on the development of inflammatory-related cancers, namely CRC and HCC.

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“…This serves to decelerate the growth of bacteria, mould, and yeasts (Ercan et al, 2015[10]). Once ingested, these salts react with water, leading to formation of bisulfite, sulfite, and sulfur dioxide.…”

Section: Introductionmentioning

confidence: 99%

“…Sulfite salts including sodium metabisulfite (Na-MBS) are often used as disinfectants, antioxidants as well as preservative compounds in food such as pastries, cheese, beverages, meat, fruit, sausages, sweets, and fish (Elmas et al, 2005[ 9 ]). This serves to decelerate the growth of bacteria, mould, and yeasts (Ercan et al, 2015[ 10 ]). Once ingested, these salts react with water, leading to formation of bisulfite, sulfite, and sulfur dioxide.…”

Section: Introductionmentioning

confidence: 99%

Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite

Mahmoudi

Honarmand

Karbalay‐Doust

et al. 2017

EXCLI Journal; 16:Doc583; ISSN 1611-2156

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Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin

Cited by 9 publications

References 44 publications

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis

Ghrelin Inhibits Intestinal Epithelial Cell Apoptosis Through the Unfolded Protein Response Pathway in Ulcerative Colitis

Role of the Ghrelin System in Colitis and Hepatitis as Risk Factors for Inflammatory-Related Cancers

Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite

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