Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol

Greay, Sara J.; Ireland, Demelza J.; Kissick, Haydn; Levy, Avram; Beilharz, Manfred W.; Riley, Thomas V.; Carson, Christine

doi:10.1007/s00280-009-1093-7

Cited by 78 publications

(57 citation statements)

References 42 publications

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“…Furthermore, bactericidal (Loughlin et al, 2008) and antifungal properties (Mondello et al, 2006) have also been found in terpinen-4-ol. Moreover, cytotoxicity of terpinen-4-ol on cancer cell lines, e.g., melanoma, has been reported (Calcabrini et al, 2004); which potently induces cell cycle arrest, apoptosis and necrotic cell death (Greay et al, 2010). There is no report of the clinically curative effect of terpinen-4-ol on cancer treatment, but terpinen-4-ol contained anti-inflammatory activity.…”

Section: Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death Inmentioning

confidence: 97%

Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells

Banjerdpongchai¹,

Khaw-on²

2013

Asian Pacific Journal of Cancer Prevention

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Section: Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death Inmentioning

confidence: 97%

Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells

Banjerdpongchai¹,

Khaw-on²

2013

Asian Pacific Journal of Cancer Prevention

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“…Furthermore, it can impair the growth of human M14 melanoma cells (Calcabrini et al, 2004) as well as induces necrotic cell death coupled with apoptotic cell death and arrests cell cycle at G1 stage in mouse malignant mesothelioma AE17 and murine melanoma B16-F10 cells (Greay et al, 2010). Further studies of potential anti-cancer drugs with a variety of cell lines are necessary, because there are high variability responses in different cancer cells following treatment with cytotoxic agents.…”

Section: Induction Of Intrinsic and Extrinsic Apoptosis Pathways In Tmentioning

confidence: 99%

Induction of Intrinsic and Extrinsic Apoptosis Pathways in the Human Leukemic MOLT-4 Cell Line by Terpinen-4-ol

Khaw-on¹,

Banjerdpongchai²

2012

Asian Pacific Journal of Cancer Prevention

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Terpinen-4-ol is a terpene found in the rhizome of Plai (Zingiber montanum (Koenig) Link ex Dietr.). In this study apoptogenic activity and mechanisms of cell death induced by terpinen-4-ol were investigated in the human leukemic MOLT-4 cell line. Terpinen-4-ol exhibited cytotoxicity in MOLT-4 cells, with characteristic morphological features of apoptosis by Wright's staining. The mode of cell death was confirmed to be apoptosis by flow cytometric analysis after staining with annexin V-FITC and propidium iodide. A sub-G1 peak in DNA histograms of cell cycle assays was observed. Terpinen-4-ol induced-MOLT-4 cell apoptosis mediated through an intrinsic pathway involving the loss of mitochondrial transmembrane potential (MTP) and release of cytochrome c into the cytosol. In addition, terpinen-4-ol also induced apoptosis via an extrinsic pathway by caspase-8 activation resulting in the cleavage of cytosolic Bid. Truncated-Bid (tBid) translocated to mitochondria and activated the mitochondrial pathway in conjunction with down-regulation of Bcl-2 protein expression. Caspase-3 activity also increased. In conclusion, terpinen-4-ol can induce human leukemic MOLT-4 cell apoptosis via both intrinsic and extrinsic pathways.

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“…131,132 p53 is also involved in the regulation of necrosis. [133][134][135][136] The functional and structural interactions between Beclin-1 and the antiapoptotic proteins Bcl-2 and Bcl-xL participate to some degree in the cross-linking of apoptosis, autophagy, and necroptosis. 98,106,137,138 Collectively, studies have indicated that apoptosis, autophagy, and necroptosis are independent but interconnected by similar pathways and share initiator or effector molecules.…”

mentioning

confidence: 99%

The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis

Lin

Song

et al. 2017

IJN

159

108

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Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to the potential unexpected toxic effects of GBMs. Here, we review the recent literature regarding the impact of GBMs on programmed cell death (PCD). Apoptosis, autophagy, and programmed necrosis are three major PCDs. Mechanistic studies demonstrated that the mitochondrial pathways and MAPKs (JNK, ERK, and p38)- and TGF-β-related signaling pathways are implicated in GBMs-induced apoptosis. Autophagy, unlike apoptosis and necroptosis which are already clear cell death types, plays a vital pro-survival role in cell homeostasis, so its role in cell death should be carefully considered. However, GBMs always induce unrestrained autophagy accelerating cell death. GBMs trigger autophagy through inducing autophagosome accumulation and lysosome impairment. Mitochondrial dysfunction, ER stress, TLRs signaling pathways, and p38 MAPK and NF-κB pathways participate in GBMs-induced autophagy. Programmed necrosis can be activated by RIP kinases, PARP, and TLR-4 signaling in macrophages after GBMs exposure. Though apoptosis, autophagy, and necroptosis are distinguished by some characteristics, their numerous signaling pathways comprise an interconnected network and correlate with each other, such as the TLRs, p53 signaling pathways, and the Beclin-1 and Bcl-2 interaction. A better understanding of the mechanisms of PCD induced by GBMs may allow for a thorough study of the toxicology of GBMs and a more precise determination of the consequences of human exposure to GBMs. These determinations will also benefit safety assessments of the biomedical and therapeutic applications of GBMs.

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Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol

Abstract: TTO and terpinen-4-ol had significant anti-proliferative activity against two tumour cell lines. Moreover, the identification of primary necrotic cell death and cell cycle arrest of the aggressive tumour cells highlights the potential anticancer activity of TTO and terpinen-4-ol.

Cited by 78 publications

References 42 publications

Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells

Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells

Induction of Intrinsic and Extrinsic Apoptosis Pathways in the Human Leukemic MOLT-4 Cell Line by Terpinen-4-ol

The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis

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