Induction of mucosal immunity through systemic immunization: Phantom or reality?

Su, Fei; Patel, G. B.; Hu, Songhua; Chen, Wangxue

doi:10.1080/21645515.2015.1114195

Cited by 137 publications

(118 citation statements)

References 104 publications

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“…4a, b). Further, the sIgA detection in feces after systemic immunization is interesting; however, while this seems to be a controversial issue, there is literature describing this type of results suggesting that vaccines systemically administered can trigger mucosal immune responses 53 . Many questions await an answer, and one of them is how the immune response moves to the mucosa after systemic immunization, which for some researchers, in addition to producing a paradigm shift, may also mean a modification in vaccine design and delivery 54 .…”

Section: Discussionmentioning

confidence: 99%

Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing Escherichia coli

et al. 2020

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Shiga toxin-producing Escherichia coli (STEC) cause diarrhea and dysentery, which may progress to hemolytic uremic syndrome (HUS). Vaccination has been proposed as a preventive approach against STEC infection; however, there is no vaccine for humans and those used in animals reduce but do not eliminate the intestinal colonization of STEC. The OmpT, Cah and Hes proteins are widely distributed among clinical STEC strains and are recognized by serum IgG and IgA in patients with HUS. Here, we develop a vaccine formulation based on two chimeric antigens containing epitopes of OmpT, Cah and Hes proteins against STEC strains. Intramuscular and intranasal immunization of mice with these chimeric antigens elicited systemic and local long-lasting humoral responses. However, the class of antibodies generated was dependent on the adjuvant and the route of administration. Moreover, while intramuscular immunization with the combination of the chimeric antigens conferred protection against colonization by STEC O157:H7, the intranasal conferred protection against renal damage caused by STEC O91:H21. This preclinical study supports the potential use of this formulation based on recombinant chimeric proteins as a preventive strategy against STEC infections.

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Section: Discussionmentioning

confidence: 99%

Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing Escherichia coli

et al. 2020

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“…Whether serum IgA was transferred to the gut and together with serum IgG, mediated protection against rotavirus infection and diarrhea requires further investigations. Systemic routes of vaccination under some circumstances (antigen, adjuvant, and delivery vehicle) have the potential to induce immune responses in the systemic system and multiple mucosal compartments [42]. …”

Section: Discussionmentioning

confidence: 99%

Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets

et al. 2016

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Live-attenuated oral rotavirus (RV) vaccines have lower efficacy in low income countries, and additionally are associated with a rare but severe adverse event, intussusception. We have been pursuing the development of an inactivated rotavirus vaccine (IRV) using the human rotavirus strain CDC-9 (G1P[8]) through parenteral immunization and previously demonstrated dose sparing and enhanced immunogenicity of intradermal (ID) unadjuvanted IRV using a coated microneedle patch in comparison with intramuscular (IM) administration in mice. The aim of this study was to evaluate the immune response and protection against RV infection and diarrhea conferred by the administration of the ID unadjuvanted IRV using the microneedle device MicronJet600® in neonatal gnotobiotic (Gn) piglets challenged with virulent Wa G1P[8] human RV. Three doses of 5 μg IRV when administered intradermally and 5 μg IRV formulated with aluminum hydroxide [Al(OH)3] when administered intramuscularly induced comparable rotavirus-specific antibody titers of IgA, IgG, IgG avidity index and neutralizing activity in sera of neonatal piglets. Both IRV vaccination regimens protected against RV antigen shedding in stools, and reduced the cumulative diarrhea scores in the piglets. This study demonstrated that the ID and IM administrations of IRV are immunogenic and protective against RV-induced diarrhea in neonatal piglets. Our findings highlight the potential value of an adjuvant sparing effect of the IRV ID delivery route.

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“…Parenteral vaccines can generate mucosal responses that produce mucosal sIgA. 53 Work in our laboratory has demonstrated mucosal immunity following parenteral vaccination in the face of maternal immunity, which generated bovine respiratory syncytial virus-specific mucosal IgA that protected against bovine respiratory syncytial virus disease. 54 Intranasal vaccines have been used because of the high concentration of lymphoid tissue in the NALT, 42 the induction of a rapid interferon response, 55 the induction of immunity against bovine respiratory disease pathogens, 28 and the lack of interference from maternal antibodies.…”

Section: Mucosal Vaccine Responsesmentioning

confidence: 99%

Mucosal Immune System of Cattle

Chase

Kaushik

2019

Veterinary Clinics of North America: Food Animal Practice

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KEYWORDS Bovine Mucosal Immunology Gastrointestinal Respiratory Reproductive Microbiome KEY POINTSThe largest organ of the immune system is the mucosa making the management of it essential for productivity and health. The mucosal barrier consists of mucous, antimicrobial peptides, and IgA and is a "kill zone" to prevent microbial invasion of the epithelium. The mucosal epithelial cells are key cells that maintain the "kill zone" and "mucosal firewall" and respond to metabolites and microbial components from the lumen and signals from immune cells to maintain tight junctions and prevent leaky gut. The mucosal immune system has a unique circulatory system where immune cells that have activated in mucosal region recirculate to mucosal regions, a system termed the common mucosal system.

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Induction of mucosal immunity through systemic immunization: Phantom or reality?

Cited by 137 publications

References 104 publications

Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing Escherichia coli

Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing Escherichia coli

Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets

Mucosal Immune System of Cattle

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