Induction of micronucleus of Oreochromis niloticus exposed to waters from the Cubatão do Sul River, southern Brazil

Fuzinatto, Cristiane Funghetto; Flohr, Letícia; Melegari, Sílvia Pedroso; Matias, William Gerson

doi:10.1016/j.ecoenv.2013.09.016

Cited by 17 publications

(5 citation statements)

References 57 publications

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“…Raw water samples of the DWTPs especially in the dry period caused significantly greater induction of erythrocytic micronuclei and nuclear buds compared to the aged tap water. Induction of erythrocytic micronuclei has also been reported in O. niloticus exposed to waters from a river in Brazil (Fuzinatto et al, 2013).…”

Section: O Niloticus Erythrocyte Based Testsmentioning

confidence: 71%

“…The test results show good correlations with mammalian test systems (Leme and Marin-Morales, 2009). Oreochromis niloticus (Nile tilapia) has been used as the bioindicator organism for genotoxicity evaluations of surface waters based on in vivo erythrocytic micronucleus tests or/and erythrocyte based comet assay (Osman et al, 2012, Fuzinatto et al, 2013. This tropical fish species is a practically feasible aquatic model especially in developing countries for screening genotoxic potential of surface water and treated water prior to distribution for drinking purposes.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenotoxicity screening of source water, wastewater and treated water of drinking water treatment plants using two in vivo test systems: Allium cepa root based and Nile tilapia erythrocyte based tests

Hemachandra

Pathiratne

2017

Water Research

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Biological effect directed in vivo tests with model organisms are useful in assessing potential health risks associated with chemical contaminations in surface waters. This study examined the applicability of two in vivo test systems viz. plant, Allium cepa root based tests and fish, Oreochromis niloticus erythrocyte based tests for screening cytogenotoxic potential of raw source water, water treatment waste (effluents) and treated water of drinking water treatment plants (DWTPs) using two DWTPs associated with a major river in Sri Lanka. Measured physico-chemical parameters of the raw water, effluents and treated water samples complied with the respective Sri Lankan standards. In the in vivo tests, raw water induced statistically significant root growth retardation, mitodepression and chromosomal abnormalities in the root meristem of the plant and micronuclei/nuclear buds evolution and genetic damage (as reflected by comet scores) in the erythrocytes of the fish compared to the aged tap water controls signifying greater genotoxicity of the source water especially in the dry period. The effluents provoked relatively high cytogenotoxic effects on both test systems but the toxicity in most cases was considerably reduced to the raw water level with the effluent dilution (1:8). In vivo tests indicated reduction of cytogenotoxic potential in the tested drinking water samples. The results support the potential applications of practically feasible in vivo biological test systems such as A. cepa root based tests and the fish erythrocyte based tests as complementary tools for screening cytogenotoxicity potential of the source water and water treatment waste reaching downstream of aquatic ecosystems and for evaluating cytogenotoxicity eliminating efficacy of the DWTPs in different seasons in view of human and ecological safety.

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Section: O Niloticus Erythrocyte Based Testsmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Cytogenotoxicity screening of source water, wastewater and treated water of drinking water treatment plants using two in vivo test systems: Allium cepa root based and Nile tilapia erythrocyte based tests

Hemachandra

Pathiratne

2017

Water Research

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“…O dicromato de potássio na concentração de 2,5 mg/L foi utilizado no estudo devido seus bons resultados na indução da formação de micronúcleos em eritrócitos de peixes, sendo visto como modelo de controle positivo para estudos toxicológicos, (16)(17) este agente induz a formação de micronúcleos citoplasmáticos devido seus efeitos clastogênicos que promovem a quebra cromossômica durante a divisão celular no organismo dos peixes. (17) A concentração de 65 μg/L do herbicida glifosato utilizada foi baseada no parâmetro estabelecido pelo Conselho Nacional do Meio Ambiente, Resolução n° 357, de 17 de março de 2005, que determina a concentração máxima permitida de glifosato para os rios brasileiros.…”

Section: Fonte: Dados Da Pesquisa (2018)unclassified

Análise dos efeitos do glifosato e sua formulação Roundup® nas células e gônadas dos peixes Danio rerio (Cyprinidae)

Carmo

Silva

Armiliato

2020

Semin. Cienc. Biol. Saude

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Os herbicidas estão entre os insumos químicos mais utilizados na agricultura e apresentam ação toxicológica para as plantas. Dentre os herbicidas existentes, o Glifosato e a sua formulação comercial Roundup são os mais utilizados devido à eficácia no controle de ervas daninhas. Entretanto, estudos sugerem que estes herbicidas podem provocar distúrbios á organismos aquáticos, principalmente o Roundup, que além do Glifosato ativo, apresenta na composição componentes surfactantes, que provavelmente aumentaria o seu potencial toxicológico para os seres vivos. Desta forma, o presente estudo teve como objetivo comparar o potencial toxicológico do herbicida Glifosato e do Roundup em peixes Danio rerio. Para isso, exemplares de D.rerio permaneceram em aquários expostos a concentração de 65 ?g/L de cada herbicida diluído em água. Foram realizadas contagens de micronúcleos e calculado o Índice Gonadossomático (IGS) e verificado os estágios de maturação gonadal. Os resultados demonstraram que os peixes expostos aos herbicidas, apresentaram aumentos significativos na frequência de micronúcleos, bem como no IGS e maior ocorrência de ovários com estágios em maturação e maduros. Não foram verificadas diferenças significativas na comparação dos herbicidas, exceto um aumento na frequência de ovários maduros nas fêmeas expostas ao Glifosato. Observou – se que mesmo em pequenas concentrações, supostamente os herbicidas poderiam ter ocasionado efeitos nocivos para os peixes D.rerio, podendo induzir efeitos clastogênicos nos eritrócitos, assim como, distúrbios reprodutivos, aumentando a preocupação sobre os impactos que estes herbicidas podem acarretar sobre o ciclo de vida destes organismos.

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“…The fish Oreochromis niloticus was employed as an experimental model because it is are easy to acquire in aquaculture systems and be of use in ecotoxicological studies in Brazil (Franco et al, 2010;Fuzzinato et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Environmental effects on the gills and blood of Oreochromis niloticus exposed to rivers of Bahia, Brazil

Cruz

Prado

Aguilar

et al. 2015

Ecotoxicology and Environmental Safety

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Induction of micronucleus of Oreochromis niloticus exposed to waters from the Cubatão do Sul River, southern Brazil

Cited by 17 publications

References 57 publications

Cytogenotoxicity screening of source water, wastewater and treated water of drinking water treatment plants using two in vivo test systems: Allium cepa root based and Nile tilapia erythrocyte based tests

Cytogenotoxicity screening of source water, wastewater and treated water of drinking water treatment plants using two in vivo test systems: Allium cepa root based and Nile tilapia erythrocyte based tests

Análise dos efeitos do glifosato e sua formulação Roundup® nas células e gônadas dos peixes Danio rerio (Cyprinidae)

Environmental effects on the gills and blood of Oreochromis niloticus exposed to rivers of Bahia, Brazil

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