INDUCTION OF LABOUR WITH PROSTAGLANDIN E<sub>2</sub>

Karim, Saiful; Hillier, Keith; Trussell, R. R.; Patel, Roma; Tamusange, S.

doi:10.1111/j.1471-0528.1970.tb03507.x

Cited by 124 publications

(36 citation statements)

References 20 publications

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“…Prostaglandins (PG) of the E and F series have been known to stimulate uterine contraction in vivo (8). In the one available report of in vitro studies, PG E1 and E2 caused an increase in uterine adenylate cyclase activity, while PGF2a was inactive (7).…”

Section: Methodsmentioning

confidence: 99%

“…It was further demonstrated that contractions produced by oxytocin, acetylcholine, and calcium were inhibited by fl-adrenergic effectors, theophylline, and dibutyryl-cAMP (3, 4) in association with an increase in adenylate cyclase activity (5-7). Prostaglandins, particularly those of the E series, are potent stimulators of uterine contraction despite the fact that they stimulate uterine adenylate cyclase activity (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Hormonal Interactions in the Uterus: Inhibition of Isoproterenol-Induced Accumulation of Adenosine 3′:5′-Cyclic Monophosphate by Oxytocin and Prostaglandins

Bhalla

Sanborn

Korenman

1972

Proc. Natl. Acad. Sci. U.S.A.

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Interactions of hormones stimulating and inhibiting uterine contraction were studied in vitro in uteri from oophorectomized rats. The ,3-adrenergic effector, isoproterenol, a potent inhibitor of contraction, produced a dose-related increase of adenylate cyclase and accumulation of adenosine 3' :5'-cyclic monophosphate (cAMP) that was inhibitable by propranolol. Oxytocin, which stimulates contraction, effectively inhibited accumulation of uterine cAMP induced by isoproterenol in the presence or absence of theophylline. Prostaglandins E2 and F2a, each at a maximum effective concentration of 0.5 AMM, also inhibited accumulation of cAMP induced by isoproterenol, consistent with their effect in stimulation of uterine contraction. Prostaglandin E2, but not prostaglandin F2a, stimulated cAMP accumulation in a dose-related manner at concentrations in excess of 0.5 MM. Neither propranolol nor oxytocin inhibited that response. Bovine endometrial adenylate cyclase failed to respond to isoproterenol but was stimulated by prostaglandins El and E2. When myometrial preparations were studied, isoproterenol stimulation and prostaglandin effects were observed as for whole castrate uterus. The competitive physiological actions of ,B-adrenergic effectors on the one hand, and oxytocin and prostaglandins on the other hand, are based on their influences on a myometrial adenylate cyclase. Stimulation of uterine cAMP accumulation by prostaglandin Ea is due to action at a different and unrelated site.Uterine tissue is designed to respond specifically to hormonal influences in order to provide the appropriate environment for implantation, fetal growth and development, and parturition. It appears to be ideal for study of the relationship between steroid-mediated and cAMP-mediated responses. Recently, it was shown that smooth muscle, particularly uterus, has an adenylate cyclase system whose activation by ,B-adrenergic effectors resulted in inhibition of contractility (1-4). It was further demonstrated that contractions produced by oxytocin, acetylcholine, and calcium were inhibited by fl-adrenergic effectors, theophylline, and dibutyryl-cAMP (3, 4) in association with an increase in adenylate cyclase activity (5-7). Prostaglandins, particularly those of the E series, are potent stimulators of uterine contraction despite the fact that they stimulate uterine adenylate cyclase activity (7,8).In these studies, we show that the stimulatory effects of oxytocin and prostaglandins E2

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hormonal Interactions in the Uterus: Inhibition of Isoproterenol-Induced Accumulation of Adenosine 3′:5′-Cyclic Monophosphate by Oxytocin and Prostaglandins

Bhalla

Sanborn

Korenman

1972

Proc. Natl. Acad. Sci. U.S.A.

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“…The uterine activity produced by prostaglandin E2 in the first and second trimesters of pregnancy is different from the prostaglandin-induced activity at or near term. On the uterus at or near term prostaglandin E2 in a concentration of 0-5-6 ,ug./minute produces normal labour-like contractions with increase in frequency and amplitude (Embrey, 1969;Karim, 1969b, Karim et al, 1970a. The tone of the uterus does not increase.…”

Section: Medicalmentioning

confidence: 96%

“…(50 ,tg./minute) for therapeutic termination of pregnancy in the first and second trimester of pregnancy (Karim et al, 1970a). Prostaglandin E2 is also effective over the same gestational period at one-tenth of the concentration.…”

Section: Medicalmentioning

confidence: 98%

“…Prostaglandins E2 and F2a have been successfully used for the induction of labour in women at or near term (Karim, 1969a(Karim, , 1969bKarim et al, 1969Karim et al, , 1970a. Prostaglandin F2a in higher concentrations (50 ,ug./minute) has also been used to stimulate the uterus in the first and second trimesters of pregnancy to induce therapeutic abortion (Karim and Filshie, 1970).…”

Section: Introductionmentioning

confidence: 99%

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THE USE OF PROSTAGLANDIN E₂ FOR THERAPEUTIC ABORTION

Karim¹,

Filshie²

1972

BJOG

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Summary: Termination of pregnancy was attempted with intravenous infusion of prostaglandin E2 (5 ug./minute) in 52 consecutive cases. Abortion was successful in 50 of these and complete in 43. There were no serious side-effects. IntroductionThe stimulant action of different prostaglandins on the intact pregnant human uterus has been shown by several investigators (Bygdeman et al., 1968;Embrey, 1969). Prostaglandins E2 and F2a have been successfully used for the induction of labour in women at or near term (Karim, 1969a(Karim, , 1969bKarim et al., 1969Karim et al., , 1970a. Prostaglandin F2a in higher concentrations (50 ,ug./minute) has also been used to stimulate the uterus in the first and second trimesters of pregnancy to induce therapeutic abortion (Karim and Filshie, 1970). In this paper we describe the effects of an intravenous infusion of 5 ,ug. of prostaglandin E2 per minute on the early and midpregnant uterus in 52 women and its usefulness for therapeutic termination of pregnancy in the first and second trimesters.

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