THE USE OF PROSTAGLANDIN E₂ FOR THERAPEUTIC ABORTION

Abstract

Summary: Termination of pregnancy was attempted with intravenous infusion of prostaglandin E2 (5 ug./minute) in 52 consecutive cases. Abortion was successful in 50 of these and complete in 43. There were no serious side-effects. IntroductionThe stimulant action of different prostaglandins on the intact pregnant human uterus has been shown by several investigators (Bygdeman et al., 1968;Embrey, 1969). Prostaglandins E2 and F2a have been successfully used for the induction of labour in women at or near term (Karim, 1969a(Karim, , 1969bKarim et al., 1969Karim et al., , 1970a. Prostaglandin F2a in higher concentrations (50 ,ug./minute) has also been used to stimulate the uterus in the first and second trimesters of pregnancy to induce therapeutic abortion (Karim and Filshie, 1970). In this paper we describe the effects of an intravenous infusion of 5 ,ug. of prostaglandin E2 per minute on the early and midpregnant uterus in 52 women and its usefulness for therapeutic termination of pregnancy in the first and second trimesters.

Why does COVID‐19 pathology have several clinical forms?

“…It not only displays interference of PGE2 in vomiting and nausea but also demonstrates its interference in abortion. [71] Interestingly, no research has shown the probability of abortion as a result of infection with SARS-COV-2. A recent case study, however, has reported abortion of a pregnant 28-year-old obese woman who was SARS-COV-2 positive.…”