Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

Gamal‐Eldeen, Amira M.; Hamdy, Nehal A.; Abdel‐Aziz, Hatem A.; El‐Hussieny, Enas A.; Fakhr, I. M. I.

doi:10.1016/j.ejmech.2014.03.021

Cited by 44 publications

(15 citation statements)

References 68 publications

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“…JC-1 aggregates would locate in the place where has high DCm and emit red fluorescence, while JC-1 monomers locate in low DCm and emit green fluorescence. The ratio of red/green is used as a marker to determine DCm [36]. A549 cells were exposed to MHMD (4 mM) for 12 h and 24 h, JC-1 staining revealed a decrease of red/green ratio, which indicates the decrease of DCm (Fig.…”

Section: The Role Of Mitochondria In Mhmd-induced Cell Apoptosismentioning

confidence: 99%

The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis

Zhou

Cao

2015

Biomedicine & Pharmacotherapy

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Section: The Role Of Mitochondria In Mhmd-induced Cell Apoptosismentioning

confidence: 99%

The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis

Zhou

Cao

2015

Biomedicine & Pharmacotherapy

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“…First, 7-Isopropyl-1,1dimethyl-1,2,3,4-tetrahydronaphthalene (2) was prepared by isomerization and aromatization of longifolene, and further oxidized and brominated to give 4,4-dimethyl-2-bromo-6-isopropyl-3,4dihydronaphthalen-1-one (4). Then, compound 4 was reacted with 5-amino-3-mercapto-1,2,4-triazole to obtain compound 2-(5-amino-1H-1,2,4-triazol-3ylthio)-6-isopropyl-4,4-dimethyl-3,4dihydronaphthalen-1(2H)-one (5). Finally, 17 target compounds, i.e., 6a-6q, were synthesized by the N-sulfonylation reaction of compound 5 with a series of substituted sulfonyl chlorides.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…The tetralin ring also exists in the structures of some clinically used anticancer drugs, for example, the anthracycline antibiotics doxorubicin, daunorubicin, epirubicin, and idarubicin [3], and so on. Many studies have been performed on tetralin derivatives for use as efficient antitumor agents [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

et al. 2020

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Seventeen novel 2-(5-amino-1-(substituted sulfonyl)-1H-1,2,4-triazol-3-ylthio)-6- isopropyl-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one compounds were synthesized from the abundant and naturally renewable longifolene and their structures were confirmed by FT-IR, NMR, and ESI-MS. The in vitro cytotoxicity of the synthesized compounds was evaluated by standard MTT assay against five human cancer cell lines, i.e., T-24, MCF-7, HepG2, A549, and HT-29. As a result, compounds 6d, 6g, and 6h exhibited better and more broad-spectrum anticancer activity against almost all the tested cancer cell lines than that of the positive control, 5-FU. Some intriguing structure–activity relationships were found and are discussed herein by theoretical calculation.

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“…[1,2,4]Triazolo[1,5‐ a ]pyrimidines act as antibacterial agents against Enterococcus faecium , anti‐influenza, antimalarial, anti‐leishmania and anti‐HIV . They represent promising anticancer agents as they inhibit tubulin by promotion of its polymerization and currently important in agricultural chemistry and as antiparasitic…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Three Component One‐pot Synthesis of Bis(aminoazolo[1,5‐a]pyrimidines) and Bis(aminoazino[1,2‐a]benzimidazoles) Bearing Thiazole Moiety

2019

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Novel bis[(thiazol‐2‐yl)acetonitrile] derivatives were prepared in good yields by the cyclocondensation of bis(bromoacetyl) derivatives with two equivalents of 2‐cyanothioacetamide in dioxane at reflux. The bis[(thiazol‐2‐yl)acetonitrile] derivatives were taken as synthetic precursors for the synthesis of novel bis(aminoazolo[1,5‐a]pyrimidines), bearing thiazole moiety. The target molecules were prepared by the three component one pot reaction of bis[(thiazol‐2‐yl)acetonitrile] derivatives, dimethylformamide‐dimethylacetal and several of 3‐aminopyrazoles in pyridine under microwave irradiation at 140 °C for 2 h. Using the same protocol, novel bis(aminotriazolo[1,5‐a]pyrimidines), bis(aminopyrimido[1,2‐a]benzimidazoles) and bis(aminopyrido[1,2‐a]benzimidazoles), incorporating thiazole moieties, were prepared by using the appropriate heterocyclic amine or 2‐(1H‐benzoimidazol‐2‐yl)acetonitrile instead of 3‐aminopyrazoles. The structure of the newly prepared thiazoles was confirmed via considering their elemental analyses and spectral data.

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Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

Cited by 44 publications

References 68 publications

The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis

The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

Microwave Assisted Three Component One‐pot Synthesis of Bis(aminoazolo[1,5‐a]pyrimidines) and Bis(aminoazino[1,2‐a]benzimidazoles) Bearing Thiazole Moiety

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