Induction of interleukin‐8 gene expression by black‐pigmented Bacteroides in human pulp fibroblasts and osteoblasts

Abstract

Black-pigmented Bacteroides are capable of amplifying the local immune response and promoting pulpal/periapical tissue inflammation by stimulating pulp fibroblasts and osteoblasts to express IL-8.

Development of an Ex Vivo Coculture System to Model Pulpal Infection by Streptococcus anginosus Group Bacteria

“…Pulpal fibroblasts which have been exposed to supernatants from these bacteria have been shown to have an inflammatory response, producing cytokines such as IL-6 and IL-8 (Yang et al 2003a;Yang et al 2003b) and stimulating production of matrix metalloproteinases (MMPs) (Chang et al 2002). Chapter 5: Antimicrobial activity of chlorhexidine and triclosan against SAG bacteria in vitro.…”

Proinflammatory Response of Human Osteoblastic Cell Lines and Osteoblast-Monocyte Interaction upon Infection withBrucellaspp

“…Besides their role in bone formation, osteoblasts have also been shown to respond to bacterial infection or bacterial products by secret-ing proinflammatory cytokines, such as IL-6 and IL-12 (2,20), and chemokines, such as macrophage chemoattractant protein 1 (MCP-1), IL-8, IP-10, and RANTES (4,31,47,49), which recruit macrophages, neutrophils, and T lymphocytes. Overall, these data point to an active role of osteoblasts in the immune responses elicited during osteoarticular infections.…”

Neuropeptide Release from Dental Pulp Cells by RgpB via Proteinase-Activated Receptor-2 Signaling

“…Cell surface-associated and secretory trypsin-like cysteine proteinases (gingipains) produced by P. gingivalis are important virulence factors and are implicated in the development of periodontitis (1,2). Periodontitis often leads to acute pulpitis and pulpal necrosis by dissemination of the pathogens and/or their virulence components (3)(4)(5)(6)(7)(8)(9)(10). Arginine-specific cysteine protease (RgpB) 2 is a gingipain (11) and has various proinflammatory activities including vascular permeability enhancement and edema induction (1,2), which can occur in acute pulpitis (12,13).…”