Induction of hepatic microsomal enzymes by diuron, phenobenzuron, and metabolites in rats

Corthay, Jacqueline; P, Medilanski; Benakis, A.

doi:10.1016/0147-6513(77)90035-5

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Bei der Fütterung mit 0,5% Benzoesäure wurde eine Verlängerung der Lebensdauer beobachtet [30]. Eine 7tägige Fütterung von 362 ppm Benzoesäure an Ratten verursachte keine Änderung der Werte des mikrosomalen Leberproteins und Zytochrom-P-450 sowie der N-Demethylierung von Aminopyrin oder der p-Hydroxylierung von Anilin [31]. Als Schwellenwert für toxische Effekte von Benzoesäure wird für Ratten 1% im Futter (= 10000 ppm = 500 mg/kg Körpergewicht) angenommen (keine näheren Angaben) [32].…”

Section: Chronische Toxizitätunclassified

Benzoesäure [MAK Value Documentation in German language, 1995]

2012

The MAK‐Collection for Occupational Health and Safety

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Section: Chronische Toxizitätunclassified

Benzoesäure [MAK Value Documentation in German language, 1995]

2012

The MAK‐Collection for Occupational Health and Safety

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“…Corthay et a1. 19 reported that 3,4dichloroaniline was capable of inducing several microsomal enzyme activities. The induction of microsomal enzyme activity is frequently accompanied by an increase in liver weight.2G22 Therefore, it is possible that the increases in liver weight observed in the aniline and 3-haloaniline treatment groups, in the absence of elevated plasma ALT/GPT activity or morphological changes, is the result of enzyme induction rather than overt toxicity.…”

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confidence: 99%

Acute renal and hepatic effects induced by 3‐haloanilines in the fischer 344 rat

Rankin

Valentovic

Nicoll

et al. 1995

J of Applied Toxicology

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Haloanilines are commonly used as chemical intermediates in the manufacture of a wide range of products. The purpose of this study was to examine the in vivo nephrotoxic and hepatotoxic potentials of the 3-haloanilines. The in vitro effects of the 3-haloanilines on renal function were also examined. In the in vivo experiments, male Fischer 344 rats (four rats/group) were administered a single intraperitoneal (i.p.) injection of an aniline hydrochloride (1.0 or 1.25 mmol kg-1) or vehicle. Renal and hepatic function were monitored at 24 and/or 48 h post-treatment. None of the 3-haloanilines were potent nephrotoxicants at either dose level. The greatest effects on renal function were observed following administration of 3-chloroaniline at a dose of 1.25 mmol kg-1 (oliguria, glucosuria, hematuria, decreased p-aminohippurate accumulation by renal cortical slices and increased blood urea nitrogen concentration). 3-Chloroaniline also was the only aniline compound to increase plasma ALT/GPT activity at 48 h. In the in vitro experiments, the ability of an aniline (10(-5) - 10(-3) M) to decrease organic ion accumulation in renal cortical slices from untreated rats was examined. The decreasing order of in vitro nephrotoxic potential was 3-iodoaniline > 3-bromoaniline > 3-chloroaniline > aniline > 3-fluoroaniline. These results indicate that the 3-haloanilines are not potent nephrotoxicants or hepatotoxicants at sublethal doses. In addition, the reasons why the 3-haloanilines have different orders of nephrotoxic potential in vivo and in vitro are not clear at this time.

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Benzoesäure [MAK Value Documentation in German language, 1986]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 11. Lieferung, Ausgabe 1986 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Chronische Toxizität Mutagenität Teratogenität Zur Frage eines MAK‐Wertes

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Induction of hepatic microsomal enzymes by diuron, phenobenzuron, and metabolites in rats

Cited by 7 publications

References 12 publications

Benzoesäure [MAK Value Documentation in German language, 1995]

Benzoesäure [MAK Value Documentation in German language, 1995]

Acute renal and hepatic effects induced by 3‐haloanilines in the fischer 344 rat

Benzoesäure [MAK Value Documentation in German language, 1986]

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