Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol

Yadetie, Fekadu; Arukwe, Augustine; Goksøyr, Anders; Male, Rune

doi:10.1016/s0048-9697(99)00226-0

Cited by 132 publications

(63 citation statements)

References 22 publications

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“…This last study offered NP in the feed whereas in the other reports the NP was administered by injection. However, fish species have shown effects on vitellogenin synthesis in both juvenile and male Atlantic salmon [86].…”

Section: Impact On Ecosystemsmentioning

confidence: 99%

Nonylphenol, an Integrated Vision of a Pollutant

et al. 2006

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Abstract. Nonylphenol is a metabolic intermediate from the microbial transformation of detergents used worldwide. While nonylphenol shows some acute toxicity, it is also able to mimic important hormones resulting in the disruption of several processes by interfering with the signals that control the overall physiology of the organism. This work perform a critical reviews on the origin, environmental fate, microbial transformation, ecosystems impact and endocrine disruption capacity of nonylphenol. Due to mass production of parent products and potential toxicity, nonylphenol is an example of a microbial decay product that may pose an environmental risk. The analysis supports the need for better tests to evaluate, model and monitor the potential long-term environmental impact of single compounds produced as a result of an environmentallymediated degradation.

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Section: Impact On Ecosystemsmentioning

confidence: 99%

Nonylphenol, an Integrated Vision of a Pollutant

et al. 2006

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“…Expression of these genes has become established biomarkers for estrogenic responses (Arukwe and Goksøyr, 2003;Yadetie et al, 1999). Reproduction and the endocrine system of fish might be susceptible towards both endocrine disrupting chemicals (EDCs) (Arcand-Hoy and Benson, 1998), multiple climatic and environmental stressors (Baroiller and D'Cotta, 2001;Schreck et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of elevated dissolved carbon dioxide and perfluorooctane sulfonic acid, given singly and in combination, on steroidogenic and biotransformation pathways of Atlantic cod

et al. 2014

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In the aquatic environments, the predicted changes in water temperature, pO2 and pCO2 could result in hypercapnic and hypoxic conditions in aquatic animals. These conditions are thought to affect several basic cellular and physiological mechanisms. Yet, possible adverse effects of elevated CO2 (hypercapnia) on teleost fish, as well as combined effects with emerging and legacy environmental contaminants are poorly investigated. In this study, juvenile Atlantic cod (Gadus morhua) were divided into groups and exposed to three different water bath PFOS exposure regimes (0 (control), 100 and 200 µg/L) for 5 days at 1hr/day, followed by three different CO2-levels (normocapnia, moderate (0.3%) and high (0.9%)). The moderate CO2 level is the predicted near future (within year 2300) level, while 0.9% represent severe hypercapnia. Tissue samples were collected at 3, 6 and 9 days after initiated CO2 exposure. Effects on the endocrine and biotransformation systems were examined by analyzing levels of sex steroid hormones (E2, T, 11-KT) and transcript expression of estrogen responsive genes (ERα, Vtg-α, Vtg-β, ZP2 and ZP3). In addition, transcripts for xenobiotic metabolizing enzymes (cyp1a and cyp3a) and hypoxiainducible factor (HIF-1α) were analyzed. Hypercapnia alone produced increased levels of sex steroid hormones (E2, T, 11-KT) with concomitant increase of estrogen responsive genes, while PFOS produced weak and time-dependent effects on E2-inducible gene transcription. Combined PFOS and hypercapnia exposure produced increased effects on sex steroid levels as observed for hypercapnia alone, with transcript expression patterns that are indicative of time-dependent interactive effects. Exposure to hypercapnia singly or in combination with PFOS produced modulations of the biotransformation and hypoxic responses that were apparently concentration and time-dependent. Loading plots of principal component analysis (PCA) produced a significant grouping of individual scores according to the exposure scenarios at day 6 and 9. Overall, the PCA analysis produced a unique clustering of variables that signifies a positive correlation between exposure to high PFOS concentration and expression of E2 responsive genes. Notably, this pattern was not evident for individuals exposed to PFOS concentrations in combination with elevated CO2 scenarios. To our knowledge, the present study is the first of its kind, to evaluate such effects using combined exposure to a perfluoroalkyl sulfonate and elevated levels of CO2 saturation, representative of future oceanic climate change, in any fish species or lower vertebrate.

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“…Nonylphenol is known to inhibit testicular growth in developing rainbow trout [18]. There is an evidence that the estrogenic effects of nonylphenol in fish are mediated by interaction with the estrogen receptors [48]. Our morphometric data on LH-ir cells from the Ishizu carp revealed a disturbance in the secretory functions: granulation and vacuolation were not in synchronization with those of control and Wada River carp.…”

Section: Discussionmentioning

confidence: 62%

Functional Changes of the LH-Immunoreactive Cells in Adenohypophysis of the Common Carp (Cyprinus carpio) from Rivers Contaminated with Estrogenic Chemicals

Hassanin

Kuwahara

Nurhidayat

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. The adverse effect of estrogenic chemicals on luteinizing hormone-immunoreactive (LH-ir) cells in the adenohypophysis of common carp (Cyprinus carpio) was examined using immunocytochemical and morphometric methods. Adult male fish were collected from two contaminated sites (Ishizu and Wada Rivers) and from a control pond at Agriculture, Food and Environmental Sciences, Research Center of Osaka Prefecture. The concentration of nonylphenol, bisphenol A and 17 β-estradiol in the Ishizu River was 3-4 times higher than that in the Wada River. The proportion and size of LH-ir cells were evaluated using the point-counting method by optical microscopy. In control carp, the proportion of LH-ir cells in the breeding season was significantly lower than in the pre-and post-breeding seasons. The same tendency was also found in Ishizu and Wada River carp, but without statistical significance. T he proportion of LH-ir cells in Ishizu River carp was significantly lower than that of the control and the Wada River in all seasons. The LHir cells in control carp increased in size in the breeding season. LH-ir cells in Ishizu River carp were significantly (p<0.05) smaller than those in control fish, but not different from Wada River carp. A disturbance in the secretory function of LH-ir cells was found in carp from the Ishizu River; granulation and vacuolation were not in synchronization with those of control and Wada River fish. Our data suggest that the estrogenic chemicals in the Ishizu River interfere with functions of LH-ir cells directly or through the testis.

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Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol

Cited by 132 publications

References 22 publications

Nonylphenol, an Integrated Vision of a Pollutant

Nonylphenol, an Integrated Vision of a Pollutant

Effects of elevated dissolved carbon dioxide and perfluorooctane sulfonic acid, given singly and in combination, on steroidogenic and biotransformation pathways of Atlantic cod

Functional Changes of the LH-Immunoreactive Cells in Adenohypophysis of the Common Carp (Cyprinus carpio) from Rivers Contaminated with Estrogenic Chemicals

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