Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD)

Zhang, Xian; Yang, Fangxing; Xu, Ying; Liao, Tao; Song, Shibo; Wang, Jianwei

doi:10.1016/j.aquatox.2007.07.002

Cited by 143 publications

(60 citation statements)

References 33 publications

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“…Besides highly oxidizable lipids, ROS could directly attack protein and it could lead to the protein carbonyl formation (Bainy et al, 1996). The formation of carbonyl proteins is non-reversible, resulting in normal protein metabolism disrupted and accumulation of damaged molecules (Zhang et al, 2008a). We observed alterations in protein carbonylation in tissues similar to those seen with LPO.…”

Section: Antioxidant Indicessupporting

confidence: 59%

“…Some of the most important antioxidant enzymes are SOD, CAT, GPx, and GR (Li et al, 2010a,d). These systems can prevent the formation of ROS, which can react with susceptible biological macromolecules and produce LPO and CP, resulting in oxidative stress (Zhang et al, 2008a;Li et al, 2010b). Many antioxidant responses, including oxidative stress biomarkers and antioxidant enzymes activities, are used in environmental risk assessment (Song et al, 2006).…”

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confidence: 99%

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Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole

Li¹,

Žlábek²,

Velíšek³

et al. 2011

CZECH J ANIM SCI

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AbstrAct:In this study, the toxic effects of PCZ, a triazole fungicide present in aquatic environment, were studied in rainbow trout, Oncorhynchus mykiss, by an acute toxicity test. Compared to the control group, fish exposed to PCZ (96-h-LC50 , 5.04 mg/l) showed significantly higher (P < 0.05) plasma NH 3 and GLU concentration and the activities of plasma enzymes including CK, ALT, AST, LDH, but the TP content was not significantly different (P > 0.05). The oxidative stress indices (levels of LPO and CP) of brain and muscle in the experimental group were higher compared to the control group, especially for a significant change (P < 0.05) in the brain. SOD, CAT, GPx and GR activity in the brain of experimental groups was significantly lower (P < 0.05), however, an opposite tendency was found out in muscle. In addition, there are significant correlations between TBARS and CAT, TBARS and GPx, CP, and CAT, GR, and GPx in the fish brain. Thus, PCZ exposure changed the oxidative stress indices and plasma characteristics, and these changes may be used as potential bioindicators of the exposure and effect of PCZ in the controlled experiment. The use in monitoring of PCZ exposure under natural field conditions is possible, but it needs further investigations.Keywords: triazole fungicide; fish; oxidative damage; blood parameters List of abbreviations PCZ = propiconazole; rOs = reactive oxygen species; LPO = lipid peroxidation; cP = carbonyl protein; sOD = superoxide dismutase; cAt = catalase; GPx = glutathione peroxidase; Gr = glutathione reductase; tbArs = thiobarbituric acid-reactive substances; DMsO = dimethyl sulphoxide; GssG = oxidized glutathione; tcA = trichloroacetic acid; bHt = butylated hydroxytoluene; DNPH = 2,4-di-nitrophenylhydrazine; EDtA = ethylenediamine-tetraacetic acid; NADPH = nicotinamide adenine dinucleotide phosphate; HUFA = highly unsaturated fatty acids; NH 3 = ammonia; GLU = glucose; tP = total proteins; cK = creatine kinase; LDH = lactate dehydrogenase; ALt = alanine aminotransferase; Ast = aspartate aminotransferase

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Section: Antioxidant Indicessupporting

confidence: 59%

mentioning

confidence: 99%

Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole

Li¹,

Žlábek²,

Velíšek³

et al. 2011

CZECH J ANIM SCI

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“…The long-term exposure of European flounder (Platichthys flesus) to HBCD did not affect their general health nor several toxicity parameters (e.g., behavior, survival, growth rate, relative liver, and gonad weight), and neither was hepatic microsomal enzyme activity (EROD) induced (Kuiper et al, 2007). In contrast, longterm exposure to HBCD induced EROD activity in rare minnow (Gobiocypris rarus), causing excess reactive oxygen species (ROS) formation that resulted in oxidative damage to lipids, proteins, and DNA and decreased antioxidant capacity (Zhang et al, 2008). Palace et al (2008) studied biotransformation enzymes and thyroid axis disruption in juvenile rainbow trout exposed to HBCD diastereoisomers, and found that disruption of the thyroid axis was most evident in the ␥-HBCD exposed group, as indicated by a decreased level of the circular free total thyroid hormone FT4, an increased level of the free total thyroid hormone FT3, and an increase in thyroid epithelial cell height.…”

Section: Introductionmentioning

confidence: 99%

Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos

et al. 2009

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“…diethylstilbestrol) and of hepatotoxic contaminants (e.g. perfluorooctanoic acid) implicated in the incidence of liver tumors in mammals (Wei et al, 2008b;Zha et al, 2007Zha et al, , 2008Zhang et al, 2008a;Zhong et al, 2005). In the year of 2014, a national standard named 'Chemicals-rare minnow (Gobiocypris rarus) acute toxicity test' (GB/T 29763-2013) was promulgated in China (General Administration of Quality Supervision Inspection and Quarantine of the People's Republic of China and Standardization Administration of the People's Republic of China, 2014).…”

Section: The Chinese Rare Minnow (Gobiocypris Rarus) As An Emerging Mmentioning

confidence: 99%

Toxicogenomic applications of Chinese rare minnow (Gobiocypris rarus) in aquatic toxicology

Liang

Zha

2016

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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Rare minnow (Gobiocypris rarus), a Chinese native species, are an excellent emerging model organism for aquatic toxicity testing and chemical safety assessment. "Big data" omics approaches (i.e., genomics, proteomics, and metabolomics) to inform mechanistic toxicology are now applied to studies in rare minnows to better understand toxicity and molecular pathways perturbed by chemicals. This review highlights recent applications of toxicogenomics to study changes in the gene and protein expression profiles in rare minnows in response to chemicals. Here we briefly describe studies that utilized cDNA microarrays in characterization of the cellular effects of rare minnows in single and mixed chemical exposures. Then we compare gel-based proteomics studies in liver of rare minnows following treatment with endocrine disrupting chemicals including 17β-estradiol, 17α-methyltestosterone, pentachlorophenol, and perfluorooctanoic acid. A total of 90 proteins identified in these studies were functionally annotated and categorized. These responsive proteins have roles in biological processes that include metabolism (37.8%), response to oxidation/chemicals (16.7%), signal transduction (11.1%), transport (10%), cytoskeleton (6.7%) and others (17.8%). In addition, recent investigations of endocrine disrupting effects and neurotoxicity of benzotriazole, an emerging contaminant, are summarized. The objective is to continue to enrich genome and protein databases for this species and to integrate molecular datasets to consider temporal effects and complex regulation at the level of the genome and proteome.

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Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD)

Cited by 143 publications

References 33 publications

Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole

Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole

Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos

Toxicogenomic applications of Chinese rare minnow (Gobiocypris rarus) in aquatic toxicology

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