Induction of Diuresis Following Transurethral Resection of the Prostate

Madsen, Paul O.; Knuth, O E; Wagenknecht, L. V.; Genster, H

doi:10.1016/s0022-5347(17)61824-x

Cited by 19 publications

(5 citation statements)

References 12 publications

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“…The systemically absorbed irrigant solution contains acid phosphatase along with prostate tissue proteins and other substances normally contained in prostate tissue [4]. As much as 6 liters of irrigant solution may be absorbed intravenously through open veins in the prostatic fossa during transurethral prostate resection [ 5 ] . Prostatic tissue substances that are soluble in the irrigant solution become absorbed intravenously along with the irrigant solution.…”

Section: Introductionmentioning

confidence: 99%

Effects of intravenous infusion of human prostate tissue substances in dogs

O'Donnell

1990

The Prostate

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Symptoms of postresection syndromes following transurethral prostatectomy have been associated with a transient increase in serum acid phosphatase due to intraoperative absorption of prostate tissue substances. Factors associated with postoperative syndromes include intraoperative absorption of irrigant solution, intraoperative blood loss, and intraoperative absorption of prostate tissue substance. An animal model was used in this study to determine the isolated physiologic effects of intravenous infusion of a saline prostate tissue extract using an infusion schedule comparable to that of transurethral prostate resection. Twenty-four animals received either normal saline infusion (control) or saline prostate tissue extract infusion (experimental). The experimental group showed a significant decrease in fibrinogen, platelet count, white blood count, activated clotting time, and plasma volume. These results suggest that the isolated effects of intravascular absorption of prostate tissue substances are due to disseminated intravascular coagulation, most likely resulting from tissue thromboplastin and activation of plasminogen.

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Section: Introductionmentioning

confidence: 99%

Effects of intravenous infusion of human prostate tissue substances in dogs

O'Donnell

1990

The Prostate

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“…Five of their patients died within 6-90 h of the operation as a result of severe haemorrhagic problems; in these patients, water was used as irrigant during resection. It is known that the amount ofirrigant solution absorbed during resection varies amongst patients (Logie et al, 1980) and as much as 6 litres of fluid can enter the blood stream (Oestar and Madsen, 1969;Madsen et al, 1970). The use of water as bladder irrigation during resection has led to intravascular haemolysis (Landsteiner and Finch, 1947) and haemolysed blood possesses thromboplastic activity (Quick et al, 1954).…”

Section: Discussionmentioning

confidence: 99%

Coagulation Tests in Predicting Haemorrhage after Prostatic Resection

Ahsan

Cartner

English

1993

British Journal of Urology

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It is known that disseminated intravascular coagulation (DIC) can contribute towards blood loss after transurethral resection of the prostate because of the absorption of various prostatic substances. The aim of the present study was to establish whether simple coagulation tests (prothrombin time/activated partial thromboplastin time) carried out immediately after surgery would be useful in predicting those patients who bleed excessively after prostatic resection due to DIC. Criteria to determine significant post-operative haemorrhage were defined. Of 110 patients entered into the study, 34.5% had significant post-operative bleeding and 74% of these had an abnormal prothrombin time (> or = 15 s) immediately after surgery. An abnormal prothrombin time was associated with the resection of large prostates but could also predict the risk of bleeding independent of the resected weight; 18% of patients with an abnormal prothrombin time were also found to have an abnormal activated partial thromboplastin time and all of these had significant blood loss. A group of patients with an abnormal prothrombin time and a resected dry weight > or = 35 g was identified as a high risk group.

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“…In 1960, volume 88 of the Journal of Urology also included eight TUR‐orientated papers; seven of these strictly used the full terminology and only one resorted to TUR (mentioned four times) [19]. In 1970, volume 104 of the Journal of Urology contained five such papers; one resorted to a TUR abbreviation only in figures, two only spelled out transurethral resection and two made extensive use of TUR and TURP (for a total of 34 uses) [20–24].…”

Section: Urological Acronyms and Other Initialismsmentioning

confidence: 99%