Effects of intravenous infusion of human prostate tissue substances in dogs

O'Donnell, Pat D.

doi:10.1002/pros.2990160106

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…The time course over which DIC evolves also varies and laboratory findings vary according to the time at which blood • PT measured immediately after resection. samples are taken relative to the initiating event (Betkurer et al, 1979;Bennet et al, 1984;O'Donnell, 1990). Hence, in the present study an abnormal prothrombin time was detectable within 20 min after prostatic resection, whereas measurements 24 h after surgery were normal.…”

Section: Discussionsupporting

confidence: 44%

“…It has been postulated that primary fibrinolysis is due to the presence of urokinase in urine and the release of tissue plasminogen activators from the prostate (Tagnon et al, 1953;McNicol et al, 1961a and b;Nijs et al, 1971). However, other studies suggest that the haemorrhage results from disseminated intravascular coagulation (DIC) and not primary fibrinolysis (Friedman et al, 1969;Giercksky et al, 1976;O'Donnell, 1990).…”

mentioning

confidence: 99%

“…In addition, measurements of prothrombin time (PT), partial thromboplastin time (PTT) and various coagulation factors remain the same when measured pre-operatively and 24 h post-operatively following resection of a benign or malignant prostate (Betkurer et al, 1979). However, in animal experiments, in which DIC occurred after intravenous infusion of prostatic tissue, abnormal clotting studies returned to normal within 2 h (O'Donnell, 1990).…”

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confidence: 99%

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Coagulation Tests in Predicting Haemorrhage after Prostatic Resection

Ahsan

Cartner

English

1993

British Journal of Urology

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It is known that disseminated intravascular coagulation (DIC) can contribute towards blood loss after transurethral resection of the prostate because of the absorption of various prostatic substances. The aim of the present study was to establish whether simple coagulation tests (prothrombin time/activated partial thromboplastin time) carried out immediately after surgery would be useful in predicting those patients who bleed excessively after prostatic resection due to DIC. Criteria to determine significant post-operative haemorrhage were defined. Of 110 patients entered into the study, 34.5% had significant post-operative bleeding and 74% of these had an abnormal prothrombin time (> or = 15 s) immediately after surgery. An abnormal prothrombin time was associated with the resection of large prostates but could also predict the risk of bleeding independent of the resected weight; 18% of patients with an abnormal prothrombin time were also found to have an abnormal activated partial thromboplastin time and all of these had significant blood loss. A group of patients with an abnormal prothrombin time and a resected dry weight > or = 35 g was identified as a high risk group.

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Section: Discussionsupporting

confidence: 44%

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confidence: 99%

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confidence: 99%

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Coagulation Tests in Predicting Haemorrhage after Prostatic Resection

Ahsan

Cartner

English

1993

British Journal of Urology

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“…These include hyperkalemia 27, hypocalcemia 28, and the release of prostatic tissue substances 29,30 and endotoxins 31 from damaged cells in the operating area. Although these factors may be important in certain patients, the present study supports the idea that natriuresis is the key factor explaining why hypovolemic hypotension develops despite administration of large amounts of fluid.…”

Section: Discussionmentioning

confidence: 99%

Fluid volume kinetics of dilutional hyponatremia; a shock syndrome revisited

Hahn¹,

Gebäck²

2014

Clinics

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OBJECTIVE:To evaluate whether the pathophysiology of shock syndromes can be better understood by comparing central hemodynamics with kinetic data on fluid and electrolyte shifts.METHODS:We studied the dilutional hyponatremic shock that developed in response to overhydration with electrolyte-free irrigating fluid – the so-called ‘transurethral resection syndrome' – by comparing cardiac output, arterial pressures, and volume kinetic parameters in 17 pigs that were administered 150 ml/kg of either 1.5% glycine or 5% mannitol by intravenous infusion over 90 minutes.RESULTS:Natriuresis appeared to be the key factor promoting hypovolemic hypotension 15–20 minutes after fluid administration ended. Excessive sodium excretion, due to osmotic diuresis caused by the irrigant solutes, was associated with high estimates of the elimination rate constant (k10) and low or negative estimates of the rate constant describing re-distribution of fluid to the plasma after translocation to the interstitium (k21). These characteristics indicated a high urinary flow rate and the development of peripheral edema at the expense of plasma volume and were correlated with reductions in cardiac output. The same general effects of natriuresis were observed for both irrigating solutions, although the volume of infused 1.5% glycine had a higher tendency to enter the intracellular fluid space.CONCLUSION:Comparisons between hemodynamics and fluid turnover showed a likely sequence of events that led to hypovolemia despite intravenous administration of large amounts of fluid.

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“…disseminated intravascular coagulation, are well described in both benign and malignant cases [ 1, 2]. One likely cause of these haemostatic complications could be the release of prostatic substances activating the clotting cascade [ 3]. Other factors, e.g.…”

Section: Introductionmentioning

confidence: 99%

Bleeding and activation of coagulation during and after transurethral prostatectomy: importance of the acute‐phase response and prostate specific antigen?

et al. 1999

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Objective To evaluate the importance of coagulation 0.024), and with the PSA concentrations (P=0.016) but not with fibrinogen. Serum concentrations of PSA activation in patients with benign prostatic hyperplasia, undergoing transurethral prostatic resection increased significantly and the AUC in the operative period correlated with F 1+2 (P=0.003) and TAT (TURP) and to examine whether changes in activity are related to blood loss, the circulatory entry of (P<0.005), but postoperatively only with F 1+2 (P= 0.013). The weight of resected tissue correlated operatprostate specific antigen (PSA), operative trauma (resected tissue weight) and the inflammatory ively with PSA (P=0.012) but not with the concentrations of F 1+2 or TAT. Postoperatively, there was a response, as assessed by C-reactive protein (CRP). Patients and methods TURP was performed in 24 men correlation with the acute-phase proteins, CRP (P=0.005), fibrinogen (P=0.012) and with PSA and the weight of resected tissue and blood loss determined. The activation of coagulation was fol-(P=0.020). Conclusion The operative blood loss is caused by surgical lowed using new sensitive and specific assays, and the changes related to blood loss, the release of PSA, factors and the observed postoperative hypercoagulable state can be explained as a physiological response operative trauma and the acute-phase response. The area under the curve (AUC) for the measured quantitto bleeding, i.e. to secure haemostasis. The activity of coagulation was unrelated to operative trauma, but ies was used in correlation analysis. Results TURP was followed by a marked activation in the acute-phase proteins were. The release of PSA into the circulation probably has an eCect on blood coagulation. There was no correlation between the markers of coagulation and the operative blood loss, coagulation.

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Effects of intravenous infusion of human prostate tissue substances in dogs

Cited by 9 publications

References 28 publications

Coagulation Tests in Predicting Haemorrhage after Prostatic Resection

Coagulation Tests in Predicting Haemorrhage after Prostatic Resection

Fluid volume kinetics of dilutional hyponatremia; a shock syndrome revisited

Bleeding and activation of coagulation during and after transurethral prostatectomy: importance of the acute‐phase response and prostate specific antigen?

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