Induction of Colonic Adenocarcinomas by 1,2-Dimethylhydrazine Intrarectally Administered in Rats

Markert, Claus; Rogers, Lowell W.; Chiu, Jen‐Fu

doi:10.1159/000198209

Digestion

1978

DOI: 10.1159/000198209

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Induction of Colonic Adenocarcinomas by 1,2-Dimethylhydrazine Intrarectally Administered in Rats

Claus Markert¹,

Lowell W. Rogers²,

Jen‐Fu Chiu³

Abstract: Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 25 0 mg DMH/kg body weight.

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1981

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Experimental adenomas and carcinomas of the large intestine behave as distinct entities: Most carcinomas arisede novo in flat mucosa

Maskens

Dujardin-Loits

1981

Cancer

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Detailed histologic analyses were performed on tumors of the large intestine obtained in 152 dimethylhydrazine (DMH)-treated rats. Of a total 539 glandular neoplasms, 45 were benign; 494 (92%) were locally invasive; of which 222 (41%) were invading the muscularis propria. One-hundred-forty-one tumors were smaller than or equal to 3mm in diameter. Among those, 127 (90%) were invasive. In addition to macroscopic nodules, several appeared after longer latency periods than did serial sections of flat mucosa. The benign polyps usually appeared after longer latency periods than did carcinomas. A review of the literature indicates that in the majority of rat experiments most or all DMH-induced tumors were frequently reported. All these data constitute strong evidence that most experimental adenocarcinomas do arise de novo in flat mucosa, i.e., without a prior adenoma stage. However, most DMH-induced tumors in mice were reported to be adenomas, either alone or coexisting with carcinomas. It is suggested that "de novo arising carcinomas" and adenomatous polyps, which are both inducible by the same carcinogens, and which can coexist in some experimental systems, nonetheless constitute independent and distinct pathologic entities; they can be separated by genetic susceptibility.

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Experimental adenomas and carcinomas of the large intestine behave as distinct entities: Most carcinomas arisede novo in flat mucosa

Maskens

Dujardin-Loits

1981

Cancer

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Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications

Nascimento-Gonçalves

Mendes

Silva-Reis

et al. 2021

Veterinary Sciences

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Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer.

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Induction of Colonic Adenocarcinomas by 1,2-Dimethylhydrazine Intrarectally Administered in Rats

Abstract: Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 25 0 mg DMH/kg body weight.

Cited by 2 publications

References 1 publication

Experimental adenomas and carcinomas of the large intestine behave as distinct entities: Most carcinomas arisede novo in flat mucosa

Experimental adenomas and carcinomas of the large intestine behave as distinct entities: Most carcinomas arisede novo in flat mucosa

Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications

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