Induction of CD8 T cell cytotoxicity by fecal bacteria from healthy individuals and colorectal cancer patients

Lu, Yanli; Wang, Linlin; Zhang, Jian; Li, Jun; Guohua, Wan

doi:10.1016/j.bbrc.2019.06.078

Cited by 3 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This effect required the presence of antigen presenting cells like monocytes and B cells and was absent when CD8 T cells alone were cultured with the gut microbes. Although in an ex vivo setting, this observation again lends to the notion that there are certain bacterial epitopes, even in dysbiotic stool of cancer patients, which harbor the potential to energize the adaptive immune cells to mount an anti-tumor immune response ( 140 ).…”

Section: Mechanisms Of Microbiome-immune Crosstalk During Cancer Initmentioning

confidence: 92%

“…Intriguingly, Lu et al ( 140 ) observed an increased degranulation and cytotoxic CD8 + T cell response on incubation of PBMC cells from healthy human volunteers with fecal bacteria from CRC patients when compared to fecal bacteria from healthy volunteers. This effect required the presence of antigen presenting cells like monocytes and B cells and was absent when CD8 T cells alone were cultured with the gut microbes.…”

Section: Mechanisms Of Microbiome-immune Crosstalk During Cancer Initmentioning

confidence: 99%

See 1 more Smart Citation

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

et al. 2021

View full text Add to dashboard Cite

The past decade has witnessed groundbreaking advances in the field of microbiome research. An area where immense implications of the microbiome have been demonstrated is tumor biology. The microbiome affects tumor initiation and progression through direct effects on the tumor cells and indirectly through manipulation of the immune system. It can also determine response to cancer therapies and predict disease progression and survival. Modulation of the microbiome can be harnessed to potentiate the efficacy of immunotherapies and decrease their toxicity. In this review, we comprehensively dissect recent evidence regarding the interaction of the microbiome and anti-tumor immune machinery and outline the critical questions which need to be addressed as we further explore this dynamic colloquy.

show abstract

Section: Mechanisms Of Microbiome-immune Crosstalk During Cancer Initmentioning

confidence: 92%

Section: Mechanisms Of Microbiome-immune Crosstalk During Cancer Initmentioning

confidence: 99%

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In recent years, fecal microbiota transplantation has improved the benefits of treatment for patients with many diseases (Lu et al, 2019). Fecal microbiota transplantation involves the transfer of fecal microbiota from a healthy donor to the patient's intestine to correct bacterial imbalances and restore intestinal homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Chen

Lin

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Colorectal cancer (CRC) ranks third in terms of global incidence and second in terms of death toll among malignant tumors. Gut microbiota are involved in the formation, development, and responses to different treatments of CRC. Under normal physiological conditions, intestinal microorganisms protect the intestinal mucosa, resist pathogen invasion, and regulate the proliferation of intestinal mucosal cells via a barrier effect and inhibition of DNA damage. The composition of gut microbiota and the influences of diet, drugs, and gender on the composition of the intestinal flora are important factors in the early detection of CRC and prediction of the results of CRC treatment. Regulation of gut microbiota is one of the most promising new strategies for CRC treatment, and it is essential to clarify the effect of gut microbiota on CRC and its possible mechanisms to facilitate the prevention and treatment of CRC. This review discusses the role of gut microbiota in the pathogenesis of CRC, the potential of gut microbiota as biomarkers for CRC, and therapeutic approaches to CRC based on the regulation of gut microbiota. It might provide new ideas for the use of gut microbiota in the prevention and treatment of CRC in the near future and thus reduce the incidence of CRC.

show abstract

Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer

Wang

Cui

Pan

et al. 2020

WJG

View full text Add to dashboard Cite

Induction of CD8 T cell cytotoxicity by fecal bacteria from healthy individuals and colorectal cancer patients

Cited by 3 publications

References 29 publications

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota

Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer

Contact Info

Product

Resources

About