Induction of bladder cancer in mice by implanting pellets containing tryptophan pyrolysis products

Hashida, Chise; Nagayama, Kazuyuki; Takemura, Nozomi

doi:10.1016/0304-3835(82)90115-x

Cited by 16 publications

(5 citation statements)

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“…In fact, the increased COX-2 expression and the activation of the mitogen activated protein kinase pathway in BC cells exposed to monomethylarsonous acid, a metabolite of inorganic arsenic, resulted a strong mechanism for BC carcinogenesis [ 10 ]. Moreover, it has been demonstrated in mice and rats the BC carcinogenicity of both 3-amino-1-methyl-5H-pyrido[4,3-b]indole, that is formed in cooked meat and fish [ 11 ], and pellets containing crude tryptophan pyrolysate and its derivates [ 12 ]. On the other hand, the exposure to high concentrations of diesel engine emissions, belonging to the sub-category of pollutants named as vehicle emissions, as well as insecticides, fungicides and pesticides resulted to contribute to carcinogenesis [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Environment and bladder cancer: molecular analysis by interaction networks

et al. 2017

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Bladder cancer (BC) is the 9th most common cancer worldwide, and the 6th most common cancer in men. Its development is linked to chronic inflammation, genetic susceptibility, smoking, occupational exposures and environmental pollutants. Aim of this work was to identify a sub-network of genes/proteins modulated by environmental or arsenic exposure in BC by computational network approaches. Our studies evidenced the presence of HUB nodes both in “BC and environment” and “BC and arsenicals” networks. These HUB nodes resulted to be correlated to circadian genes and targeted by some miRNAs already reported as involved in BC, thus suggesting how they play an important role in BC development due to environmental or arsenic exposure. Through data-mining analysis related to putative effect of the identified HUB nodes on survival we identified genes/proteins and their mutations on which it will be useful to focus further experimental studies related to the evaluation of their expression in biological matrices and to their utility as biomarkers of BC development.

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Section: Introductionmentioning

confidence: 99%

Environment and bladder cancer: molecular analysis by interaction networks

et al. 2017

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“…HCAs and PAHs are mutagenic and carcinogenic in animal studies,29, 30 and some HCAs induce bladder tumors specifically 31–33. Two case-control studies of HCAs from meat in relation to bladder cancer have been null 34, 35…”

Section: Introductionmentioning

confidence: 99%

“…HCAs and PAHs are mutagenic and carcinogenic in animal studies, 29,30 and some HCAs induce bladder tumors specifically. [31][32][33] Two case-control studies of HCAs from meat in relation to bladder cancer have been null. 34,35 We evaluated the role of meat, nitrate, nitrite, and meat mutagens in relation to transitional-cell bladder cancer in a large, prospective, cohort study by using a detailed meat questionnaire linked to a database of published values from the literature and quantitative databases of laboratory measures of meat samples.…”

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confidence: 99%

“…Given the role of aromatic amines and PAHs from occupational exposures in bladder cancer and the presence of these compounds in cigarette smoke, another important risk factor, heterocyclic amines (HCAs) and PAHs formed in meats prepared by high temperature cooking methods,25‐28 could be implicated in this malignancy. HCAs and PAHs are mutagenic and carcinogenic in animal studies,29, 30 and some HCAs induce bladder tumors specifically 31‐33. Two case‐control studies of HCAs from meat in relation to bladder cancer have been null 34, 35…”

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confidence: 99%

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Meat and components of meat and the risk of bladder cancer in the NIH‐AARP Diet and Health Study

Ferrucci

Sinha

Ward

et al. 2010

Cancer

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BACKGROUND: Meat could be involved in bladder carcinogenesis via multiple potentially carcinogenic meat-related compounds related to cooking and processing, including nitrate, nitrite, heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs). The authors comprehensively investigated the association between meat and meat components and bladder cancer. METHODS: During 7 years of follow-up, 854 transitional cell bladder-cancer cases were identified among 300,933 men and women who had completed a validated food-frequency questionnaire in the large prospective NIH-AARP Diet and Health Study. The authors estimated intake of nitrate and nitrite from processed meat and HCAs and PAHs from cooked meat by using quantitative databases of measured values. Total dietary nitrate and nitrite were calculated based on literature values. RESULTS: The hazard ratios (HR) and 95% confidence intervals (CI) for red meat (HR for fifth quintile compared with first quintile, 1.22; 95% CI, 0.96-1.54; P trend ¼ .07) and the HCA 2-amino-1 methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) (HR, 1.19; 95% CI, 0.95-1.48; P trend ¼ .06) conferred a borderline statistically significant increased risk of bladder cancer. Positive associations were observed in the top quintile for total dietary nitrite (HR, 1.28; 95% CI, 1.02-1.61; P trend ¼ .06) and nitrate plus nitrite intake from processed meat (HR, 1.29; 95% CI, 1.00-1.67; P trend ¼ .11). CONCLUSIONS: These findings provided modest support for an increased risk of bladder cancer with total dietary nitrite and nitrate plus nitrite from processed meat. Results also suggested a positive association between red meat and PhIP and bladder carcinogenesis. Cancer 2010;116:4345-53.

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“…However, these meat mutagens have been associated with an increased risk of breast, colorectal, upper gastrointestinal, lung, pancreatic, and prostate cancer (Alaejos et al , 2008; Zheng and Lee, 2009). Furthermore, HCAs induce tumours in multiple organs in animal studies (Ohgaki et al , 1987), including the urinary tract (Hashida et al , 1982 Takahashi et al , 1993). …”

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confidence: 99%

Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States

Cross

Baris

et al. 2012

Br J Cancer

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Background:Despite many studies on diet and bladder cancer, there are areas that remain unexplored including meat mutagens, specific vegetable groups, and vitamins from diet.Methods:We conducted a population-based case–control study of bladder cancer in Maine, New Hampshire, and Vermont. A total of 1171 cases were ascertained through hospital pathology records and cancer registries from 2001 to 2004. Overall, 1418 controls were identified from the Department of Motor Vehicles (<65 years) and Center for Medicaid and Medicare Services (65–79 years) and were frequency-matched to cases by state, sex, and age (within 5 years). Diet was assessed with a self-administered Diet History Questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results:Processed meat intake was positively associated with bladder cancer (highest vs lowest quartile OR: 1.28; 95% CI: 1.00–1.65; Ptrend=0.035), with a stronger association for processed red meat (OR: 1.41; 95% CI: 1.08–1.84; Ptrend=0.024). There were no associations between intake of fruits or vegetables and bladder cancer. We did, however, observe an inverse association with vitamin B12 intake (OR: 0.77; 95% CI: 0.61–0.99; P=0.019).Conclusion:Vitamin B12 from diet may be protective against bladder cancer, whereas consuming processed meat may increase risk.

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Induction of bladder cancer in mice by implanting pellets containing tryptophan pyrolysis products

Cited by 16 publications

References 4 publications

Environment and bladder cancer: molecular analysis by interaction networks

Environment and bladder cancer: molecular analysis by interaction networks

Meat and components of meat and the risk of bladder cancer in the NIH‐AARP Diet and Health Study

Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States

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