Environment and bladder cancer: molecular analysis by interaction networks

Polo, Andrea; Crispo, Anna; Pellegrino, C.; Falzone, Luca; Candido, Saverio; Giudice, Aldo; Petro, Giuseppina De; Ciliberto, Gennaro; Montella, Maurizio; Budillon, Alfredo; Costantini, Susan

doi:10.18632/oncotarget.18222

Cited by 42 publications

(48 citation statements)

References 53 publications

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“…Previous research shows that miR-30a-5p acts as a tumor suppressor in a kind of cancers, such as gastric cancer (11) and hepatocellular carcinoma (12). Other reports also showed that miR-30 family exerts an important roles in breast cancer (13), papillary thyroid cancer (14) and bladder cancer (15). However, whether miR-30a-5p plays a role or not in melanoma remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4

Liu

Sun

et al. 2018

Mol Med Report

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MicroRNA (miR)‑30a‑5p has been reported to suppress the progression of hepatocellular cancer, renal cell carcinoma, oral cancer and gastric cancer. However, whether miR‑30a‑5p is involved in the regulation of melanoma remains unclear. The present study revealed that miR‑30a‑5p was downregulated in melanoma tissues and cell lines. Overexpression of miR‑30a‑5p significantly inhibited the proliferation, migration and invasion of melanoma cells in vitro. In addition, ectopic expression of miR‑30a‑5p delayed tumor growth in vivo. In terms of mechanism, miR‑30a‑5p targeted sex determining region Y‑box 4 (SOX4) and impeded the expression of SOX4 in melanoma cells. In addition, SOX4 was upregulated in melanoma tissues and cell lines when compared with normal tissues or cells. Furthermore, overexpression of SOX4 significantly rescued the proliferation, migration and invasion of melanoma cells transfected with miR‑30a‑5p mimics. Taken together, the results of the present study demonstrated that miR‑30a‑5p suppressed the proliferation, migration and invasion of melanoma cells in SOX4‑dependent manner.

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Section: Introductionmentioning

confidence: 99%

miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4

Liu

Sun

et al. 2018

Mol Med Report

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“…In previous studies it was speculated the potential role of a bioinformatics approach to identify miRNAs with high diagnostic and prognostic significance in cancer development and progression [ 40 – 44 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development

Falzone

Scola

Zanghì

et al. 2018

Aging

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112

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Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently, no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore, there is a need to discover new molecules able to identify pre-cancerous lesions. Recently, microRNAs (miRNAs) have been associated with the onset of specific pathologies, thus the identification of miRNAs associated to colorectal cancer may be used to detect this pathology at early stages. On these bases, the expression levels of miRNAs were analyzed to compare the miRNAs expression levels of colorectal cancer samples and normal tissues in several miRNA datasets. This analysis revealed a group of 19 differentially expressed miRNAs. To establish the interaction between miRNAs and the most altered genes in CRC, the mirDIP gene target analysis was performed in such group of 19 differentially expressed miRNAs. To recognize miRNAs able to activate or inhibit genes and pathways involved in colorectal cancer development DIANA-mirPath prediction analysis was applied. Overall, these analyses showed that the up-regulated hsa-miR-183-5p and hsa-miR-21-5p, and the down-regulated hsa-miR-195-5p and hsa-miR-497-5p were directly related to colorectal cancer through the interaction with the Mismatch Repair pathway and Wnt, RAS, MAPK, PI3K, TGF-β and p53 signaling pathways involved in cancer development.

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“…Then, we focused our attention on the PPI network specifically obtained from the immune response gene products, since it has been described that deregulation of genes, encoding for highly interactive proteins, interferes with physiological processes and that molecules involved in diseases development show a high attitude to interact with each other [ 77 ]. The clustering analysis of this sub-network helped us to further prioritize deregulated gene products that were placed in “highest connectivity areas” (clusters) of the network, where the hubs of biological process regulation are usually positioned [ 78 ].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy

Puccetti

Fiore

Pelosi

et al. 2018

Journal of Immunology Research

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Behçet disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions. Disease etiopathogenesis is still unclear. We aim to elucidate some aspects of BD pathogenesis and to identify specific gene signatures in peripheral blood cells (PBCs) of patients with active disease using novel gene expression and network analysis. 179 genes were modulated in 10 PBCs of BD patients when compared to 10 healthy donors. Among differentially expressed genes the top enriched gene function was immune response, characterized by upregulation of Th17-related genes and type I interferon- (IFN-) inducible genes. Th17 polarization was confirmed by FACS analysis. The transcriptome identified gene classes (vascular damage, blood coagulation, and inflammation) involved in the pathogenesis of the typical features of BD. Following network analysis, the resulting interactome showed 5 highly connected regions (clusters) enriched in T and B cell activation pathways and 2 clusters enriched in type I IFN, JAK/STAT, and TLR signaling pathways, all implicated in autoimmune diseases. We report here the first combined analysis of the transcriptome and interactome in PBCs of BD patients in the active stage of disease. This approach generates useful insights in disease pathogenesis and suggests an autoimmune component in the origin of BD.

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Environment and bladder cancer: molecular analysis by interaction networks

Cited by 42 publications

References 53 publications

miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4

miR‑30a‑5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4

Integrated analysis of colorectal cancer microRNA datasets: identification of microRNAs associated with tumor development

Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy

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