2018
DOI: 10.18632/aging.101444
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Abstract: Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently, no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore, there is a need to discover new molecules able to identify pre-cancerous lesions. Recently, microRNAs (miRNAs) have been associated with the onset of specific pathologies, thus the identification of miRNAs associated to colorectal cancer may be used to detect this pathology at early stages. On these bases, the expression levels of … Show more

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Cited by 130 publications
(108 citation statements)
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References 68 publications
(49 reference statements)
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“…We also studied the possible diagnostic and prognostic value of TSPAN32 expression in PBMC of MS patients, on the course of the disease. The use of whole-genome expression databases has been largely exploited [25][26][27][28] for the characterization of pathogenic pathways and to identify therapeutic targets for a…”
Section: Discussionmentioning
confidence: 99%
“…We also studied the possible diagnostic and prognostic value of TSPAN32 expression in PBMC of MS patients, on the course of the disease. The use of whole-genome expression databases has been largely exploited [25][26][27][28] for the characterization of pathogenic pathways and to identify therapeutic targets for a…”
Section: Discussionmentioning
confidence: 99%
“…The PPIA expression level also implied the clinical characteristics of resected lung adenocarcinomas and was correlated with a poor prognosis of lung adenocarcinoma (Nakano et al, 2017).However, the in-depth study of the PPIA overexpression mechanism in CRC was insufficient. Analysis of TCGA miRNA-sequencing data showed that downregulation of hsa-miR-1-3p may be a diagnostic marker of CR and that it was significantly related with the pathological stage (Zhou et al, 2018;Falzone et al, 2018). Therefore, further molecular biology experiments may be able to prove the interaction of the downregulation of hsa-miR-1-3p and the upregulation of PPIA, which is conducive to a better understanding of the CRC posttranscriptional regulation mechanism.…”
Section: Discussionmentioning
confidence: 98%
“…These biomarkers can be used for early diagnosis, individualized treatment and prognosis of colorectal cancer [36]. For example, hsa-mir-183-5p and hsa-mir-21-5p [37], hsa-mir-30a [38], hsa-mir-96 [39], hsa-mir-21 [40] for diagnosis of colorectal cancer. And hsa-mir-143 and hsa-mir-145 for prognosis of colorectal cancer [41].…”
Section: Discussionmentioning
confidence: 99%
“…CEA, CA19-9 and CA24-2 were measured routinely by flow fluorescence method with Quantitative Detection Kit for Tumor Markers (Tellgen Life Science, Shanghai, China). Critical value of CEA, CA19-9 and CA24-2 was 5.00ng/mL, 37.00U/mL and 20.00U/mL. The results were considered positive when any of the markers were positive, and negative when all of the markers were negative.…”
Section: Sample Preparation and Tumor Markers Detectionmentioning
confidence: 99%