Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock

Tayar, Lamin; Higo, Kyoko; Kubo, Yasuo; Wang, Yun; Лу, Л.; Zhang, Fengmin; Iwatani, Yoshinori; Ono, Takeshi; Maeda, Masako; Sakai, Hiroyuki; Ishimoto, Akinori

doi:10.1128/jvi.73.2.1640-1644.1999

Cited by 8 publications

(1 citation statement)

References 19 publications

(17 reference statements)

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“…BM5eco) for its entry into cells and spread in vivo. The ensuing murine acquired immunodeficiency syndrome, termed murine AIDS (MAIDS) (Latarjet and Duplan, 1962;Mosier et al, 1985), exhibits many features shared with HIV-induced disease in man (Aziz et al, 1989;Jolicoeur, 1991;Morse et al, 1992;Tayar et al, 1999;Casabianca et al, 2003). Similarities include early onset hypergammaglobulinemia (hyper-Ig), splenomegaly, and lymphadenopathy; dependence on CD4 T cells for initiation of disease; loss of CD4 T cell function; severely depressed T and B cell responses; increased susceptibility to infection and death when exposed to normally nonpathogenic microorganisms; and the development of terminal B-cell lymphomas.…”

Section: Introductionmentioning

confidence: 99%

Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Green

2007

Virology

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LP-BM5, a retroviral isolate, induces a disease featuring an acquired immunodeficiency syndrome termed murine AIDS (MAIDS). Many of the features of the LP-BM5-initiated disease are shared with HIV/AIDS. Our lab has shown that the interaction of B and CD4 T cells that is central to MAIDS pathogenesis requires ligation of CD40 on B cells by CD154 on CD4 T cells. Despite this strict requirement for CD154 expression, whether CD4 T cell receptor (TCR) occupancy is essential for the induction of MAIDS is unknown. To block TCR engagement, Tg mouse strains with monoclonal TCR of irrelevant peptide/MHC specificities, all on MAIDS-susceptible genetic backgrounds, were tested: the study of a panel of TCR Tg CD4 T cells controlled for the possibility of serendipitous crossreactive recognition of virus-associated or induced-self peptide, or superantigen, MHC complexes by a given TCR. The results argue that TCR engagement is not necessary for the induction of MAIDS.

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Section: Introductionmentioning

confidence: 99%

Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Green

2007

Virology

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Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Rastad

Green

2016

Virology

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Monocytic myeloid-derived suppressor cells (M-MDSCs) were increased during LP-BM5 retroviral infection, and were capable of suppressing not only T-cell, but also B-cell responses. In addition to previously demonstrating iNOS- and VISTA-dependent M-MDSC mechanisms, in this paper, we detail how M-MDSCs utilized soluble mediators, including the reactive oxygen and nitrogen species superoxide, peroxynitrite, and nitric oxide, and TGF-β, to suppress B cells in a predominantly contact-independent manner. Suppression was independent of cysteine-depletion and hydrogen peroxide production. When two major mechanisms of suppression (iNOS and VISTA) were eliminated in double knockout mice, M-MDSCs from LP-BM5-infected mice were able to compensate using other, soluble mechanisms in order to maintain suppression of B cells. The IL-10 producing regulatory B-cell compartment was among the targets of M-MDSC-mediated suppression.

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Pathogenic risk of endogenous retrovirus infection in immunodeficient hosts

Zhang¹,

Da²,

Song³

et al. 2008

Virus Research

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Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock

Cited by 8 publications

References 19 publications

Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?

Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β

Pathogenic risk of endogenous retrovirus infection in immunodeficient hosts

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