Induction of Antioxidant Enzymes by Curcumin and Its Analogues in Human Islets

Balamurugan, A. N.; Akhov, Leonid; Selvaraj, Gopalan; Pugazhenthi, Subbiah

doi:10.1097/mpa.0b013e318196c3e7

Cited by 40 publications

(31 citation statements)

References 32 publications

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“…This effect was accompanied by generation of electrical activity and depolarisation which resulted in enhanced insulin release [32]. Curcuminoids increased the expression of the antioxidant enzymes heme-oxygenase 1 and NADPH:quinone oxidoreductase 1 at messenger ribonucleic acid (mRNA) levels up to 12-fold and at protein levels by 6-fold in human islets (used for human transplantation) [33]. These observations suggest that curcumin might be beneficial in improving cellular defense mechanisms against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Thota

Acharya

Abbott

et al. 2016

Trials

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BackgroundLifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D. In the current trial we propose to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids on improving glycosylated haemoglobin as a primary outcome, along with secondary outcomes of glycaemic indices, lipid profile and inflammatory parameters.Methods/designEighty individuals diagnosed with prediabetes, aged between 30 and 70 years, will be randomly assigned to double placebo, curcumin alone, fish oil alone or double active groups according to a computer-generated randomisation sequence for 12 weeks. At baseline and post-intervention visits participants will be asked to provide blood samples and undergo body composition measurements. A blood sample is used for estimating glycaemic profiles, lipid profiles and inflammatory parameters (C-reactive protein, whole blood cell count, adiponectin, leptin, interleukin-6). The interim visit includes review on compliance with supplements based on capsule log and capsule count, adverse events and anthropometric measurements. In addition to these procedures, participants provide self-reported questionnaires on dietary intake (using a 3-day food record), a physical activity questionnaire and medical history.DiscussionThis trial aims to determine whether curcumin and/or long-chain omega-3 polyunsaturated fatty acids affect surrogate markers of glycaemic control which is relevant to delaying T2D. To date 38 participants completed the trial. No changes have been made to the clinical protocol post recruitment. If successful, this trial will provide considerable evidence for performing a larger trial to investigate whether this combination can be administered for preventing or delaying the onset of T2D in high-risk individuals.Trial registration ACTRN12615000559516, registered on 29 May 2015).Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1702-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Thota

Acharya

Abbott

et al. 2016

Trials

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“…They also increase antioxidant enzyme activities and islet content of glutathione and thereby protect islets from oxidative stress (Balamurugan et al, 2009). MCP-1 has been shown to…”

Section: Effect Of Curcumin On Pancreaticߚ-cell Dysfunctionmentioning

confidence: 99%

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Ghosh

Banerjee

Sil

2015

Food and Chemical Toxicology

435

250

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“…The decrease might be due to radiation induced production of free radicals which in turn can impair the antioxidant defence mechanism leading to an increased membrane lipid peroxidation (Bhatia and Jain, 2004;Sehgal et al, 2012). The decreased GSH levels may be due to their utilization by the enhanced production of ROS (Suryanarayana et al, 2007;Balamurugan et al, 2009). After 24 h of treatment with X-ray depletion in GSH and SOD levels were also observed.…”

Section: Discussionmentioning

confidence: 92%

Curcumin Protects Metronidazole and X-ray Induced Cytotoxicity and Oxidative Stress in Male Germ Cells in Mice

2013

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Metronidazole (MTZ) is a common antiparasitic and antibacterial drug. The drug and X-ray induced effects in mouse sperm count, sperm head abnormality and some oxidative stress parameters have been studied. Simultaneously the protective role of curcumin has been evaluated. MTZ, 40 mg/kg bw and 13.4 mg/kg bw × 3 days exposure induced abnormal sperm head and reduced total sperm count in Swiss albino mice both after 24 h and 35 days of exposure. However, MTZ treatment in mice receiving X-ray irradiation (0.5 Gy) did not changed the incidence of abnormal sperm population or decrease in the total sperm count. Hepatic glutathione (GSH), superoxide dismutase (SOD) declined significantly during the treatment phase with significant rise in lipid peroxidation of the tissue. The cellular changes were estimated by using lipid peroxidative indices like thiobarbituric acid reactive substances (TBARS). Elevated TBARS is indicative of oxidative stress in treated mice. Furthermore, curcumin pre-treatment apparently reduced the frequency of sperm head abnormality and TBARS induced by MTZ alone or in combination with X-ray and increased the levels of hepatic GSH and SOD. The additive effects of MTZ and X-ray could not be observed with regards to sperm head abnormality and total sperm count in the tested dose range although the cellular antioxidants were found to be significantly lowered and lipid peroxidantion increased. The possible role of MTZ and X-ray inducing sperm abnormality, decreased sperm count and alteration in GSH, SOD and TBARS and defensive role of curcumin have been evaluated.

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Induction of Antioxidant Enzymes by Curcumin and Its Analogues in Human Islets

Abstract: Our observations suggest that curcumin or its analogues could be used to induce cellular defense against oxidative stress and improve islet transplantation outcomes.

Cited by 40 publications

References 32 publications

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

Curcumin Protects Metronidazole and X-ray Induced Cytotoxicity and Oxidative Stress in Male Germ Cells in Mice

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