Induction of Age Pigment Accumulation in the Brain Cells of Young Male Rats Through Iron-Injection Into the Cerebrospinal Fluid

Zs.‐Nagy, Imre; Steiber, János; Jeney, Florence

doi:10.1159/000213732

Cited by 18 publications

(8 citation statements)

References 25 publications

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“…Mitochondria are the primary organelle for oxygen radical production via the respiratory chain. Zs-Nagy et al [32] also reported that the cerebellum was a region where Fe 2+ accumulated. By analysis of the Mn SOD activity of the six brain regions at different ages, we found that the activity was lower in the frontal and occipital lobes of 1-month-old rats ( fig.…”

Section: Discussionmentioning

confidence: 95%

Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Tsay¹,

Wang²,

Wang³

et al. 2000

J Biomed Sci

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Oxygen free radicals have been proposed to be involved in the process of aging. Superoxide dismutase (SOD) and catalase are important for antioxidative defense. In this study, profiles of SOD, catalase, and their mRNA levels were investigated in the frontal, parietal, temporal and occipital lobes, subcortex and cerebellum of male Wistar rats at ages 1-21 months. The total SOD and Mn SOD activities increased with age and exhibited higher levels at 6 and 12 months but decreased thereafter. Activity of catalase showed a similar trend and notably peaked at 12 months. The mRNA levels of Cu/Zn SOD, Mn SOD, and catalase remained constant in all areas tested (frontal, parietal, temporal and occipital lobes, and subcortex) except the cerebellum. Post-transcriptional regulation was involved in modulating the enzymes' activities during aging. Furthermore, the rate of mitochondrial generation of the superoxide anion (O(2)(-).) increased gradually with aging. Taken together, the results suggest that the increase of oxidative potential and the loss of proper antioxidant defense in the rats appear to be highly involved in the aging process of the brain.

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Section: Discussionmentioning

confidence: 95%

Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Tsay¹,

Wang²,

Wang³

et al. 2000

J Biomed Sci

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“…54 Earlier studies demonstrated that enhanced amounts of lysosomal redoxactive iron accelerated the lipofuscin accumulation in cultured human glial cells 139 and neonatal rat cardiac myocytes, 140 while in rat brain neurons the lipofuscin content was increased by intralumbar injections of iron. 141 Further supporting the involvement of iron and oxidation in lipofuscin accumulation, the iron chelator desferrioxamine and various antioxidants (e.g. vitamin E, selenium, glutathione, etc.)…”

Section: Characteristics Of Age-related Damagementioning

confidence: 95%

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

Terman

2001

Redox Report

139

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Increasing evidence suggests an important role of oxidant-induced damage in the progress of senescent changes, providing support for the free radical theory of aging proposed by Harman in 1956. However, considering that biological organisms continuously renew their structures, it is not clear why oxidative damage should accumulate with age. No strong evidence has been provided in favor of the concept of aging as an accumulation of synthetic errors (e.g. Orgel's 'error-catastrophe' theory and the somatic mutation theory). Rather, we believe that the process of aging may derive from imperfect clearance of oxidatively damaged, relatively indigestible material, the accumulation of which further hinders cellular catabolic and anabolic functions. From this perspective, it might be predicted that: (i) suppression of oxidative damage would enhance longevity; (ii) accumulation of incompletely digested material (e.g. lipofuscin pigment) would interfere with cellular functions and increase probability of death; (iii) rejuvenation during reproduction is mainly provided by dilution of undigested material associated with intensive growth of the developing organism; and (iv) age-related damage starts to accumulate substantially when development is complete, and mainly affects postmitotic, cells and extracellular matrix, not proliferating cells. There is abundant support for all these predictions.

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“…These include the ubiquitous lipofuscin (Serot et al, 2000;Wen et al, 1999), or age-pigment, that accumulates in all long-lived cell types and is considered to be a product of lipid peroxidation by oxygen free radicals (Zs-Nagy et al, 1995). From middle age, there is also a marked increase in protein inclusions, notably Biondi ring tangles in the epithelium (Eriksson and Westermark, 1986;Wen et al, 1999).…”

Section: Age-related Alterations To the Mammalian Choroid Plexus Morpmentioning

confidence: 99%

Ageing choroid plexus-cerebrospinal fluid system

Preston

2000

Microsc. Res. Tech.

190

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The impact of ageing on the choroid plexus (CP)‐CSF circulatory system has largely been un‐investigated, or has been of interest only in relation to neurological disease. This paper reviews the evidence for age‐related changes to the CP‐CSF system and compares changes with disease states where appropriate. The changes discussed include reduced ion transport capabilities, evidence for oxidative stress, altered hormone interactions, decreased CSF secretion rates in animal models and the contradictory nature of human data, reduced clearance of protein from CSF, and slower fluid turnover. The potential impacts of these changes are highlighted, including the possibility of reduced resistance to stress insults and slow clearance of toxic compounds from CSF with specific reference to amyloid peptide. Other impacts may include the reduced ability of CSF to act as a circulating medium for hormone and growth factors to reach their brain targets, and reduced homeostasis of CSF nutrients (amino acids, vitamins), which might influence brain interstitial fluid homeostasis. Microsc. Res. Tech. 52:31–37, 2001. © 2001 Wiley‐Liss, Inc.

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Induction of Age Pigment Accumulation in the Brain Cells of Young Male Rats Through Iron-Injection Into the Cerebrospinal Fluid

Cited by 18 publications

References 25 publications

Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

Ageing choroid plexus-cerebrospinal fluid system

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