Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Tsay, Huey Jen; Wang, Pei; Wang, Shyang Long; Ku, Hung Hai

doi:10.1007/bf02253362

Cited by 71 publications

(36 citation statements)

References 30 publications

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“…SOD activity is increased with age until 12 months and decreased after 12 months in the rat brain (Tsay et al 2000). Cell culture study (Chan et al 2009) and our results are consistent in this regard revealing that treatment with astaxanthin restores the activity of CAT.…”

Section: Discussionsupporting

confidence: 93%

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

et al. 2015

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Astaxanthin is a potential antioxidant which shows neuroprotective property. We aimed to investigate the age-dependent and region-specific antioxidant effects of astaxanthin in mice brain. Animals were divided into 4 groups; treatment young (3 months, n = 6) (AY), treatment old (16 months, n = 6) (AO), placebo young (3 months, n = 6) (PY) and placebo old (16 months, n = 6) (PO) groups. Treatment group was given astaxanthin (2 mg/kg/day, body weight), and placebo group was given 100 μl of 0.9% normal saline orally to the healthy Swiss albino mice for 4 weeks. The level of non-enzymatic oxidative markers namely malondialdehyde (MDA); nitric oxide (NO); advanced protein oxidation product (APOP); glutathione (GSH) and the activity of enzymatic antioxidants i.e.; catalase (CAT) and superoxide dismutase (SOD) were determined from the isolated brain regions. Treatment with astaxanthin significantly (p < 0.05) reduces the level of MDA, APOP, NO in the cortex, striatum, hypothalamus, hippocampus and cerebellum in both age groups. Astaxanthin markedly (p < 0.05) enhances the activity of CAT and SOD enzymes while improves the level of GSH in the brain. Overall, improvement of oxidative markers was significantly greater in the young group than the aged animal. In conclusion, we report that the activity of astaxanthin is age-dependent, higher in young in compared to the aged brain.

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Section: Discussionsupporting

confidence: 93%

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

et al. 2015

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“…The burden of ROS during aging may induce protein oxidation and result in the disruptions of the antioxidant enzymes in the brain, which are responsible for the scavenger of free radicals. Previous studies revealed that antioxidant enzyme activities (SOD1, SOD2, catalase, and glutathione peroxidase) showed age-related decrease in the brain, indicating that the antioxidant defense declined during aging and neurodegenerative diseases [8,9,11,31]. In our results, SOD1, SOD2, Prdx1, and PPIA were oxidized in the aged rat temporal cortex.…”

Section: Discussioncontrasting

confidence: 40%

“…However, the activities of many pivotal antioxidant enzymes (SOD1, SOD2, catalase, and glutathione peroxidase) decrease in the aged rat [8][9][10][11]. Furthermore, the intracellular glutathione concentration was found to decrease with age in the brain [12,13].…”

Section: Introductionmentioning

confidence: 92%

Differential Proteomics Analysis of Specific Carbonylated Proteins in the Temporal Cortex of Aged Rats: The Deterioration of Antioxidant System

Wang

Zhao

et al. 2009

Neurochem Res

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Oxidative stress plays a pivotal role in normal brain aging and various neurodegenerative diseases, including Alzheimer's disease (AD). Irreversible protein carbonylation, a widely used marker for oxidative stress, rises during aging. The temporal cortex is essential for learning and memory and particularly susceptible to oxidative stress during aging and in AD patients. In this study, we used 2-DE, MALDI-TOF/TOF MS, and Western blotting to analyze the differentially carbonylated proteins in the rat temporal cortex between 1-month-old and 24-month-old. We showed that the carbonyl levels of ten protein spots corresponding to six gene products: SOD1, SOD2, peroxiredoxin 1, peptidylprolyl isomerase A, cofilin 1, and adenylate kinase 1, significantly increased in the temporal cortex of aged rats. These proteins are associated with antioxidant defense, the cytoskeleton, and energy metabolism. Several oxidized proteins identified in aged rat brain are known to be involved in neurodegenerative disorders as well. Our findings indicate that these carbonylated proteins may be implicated in the decline of normal brain aging process and provide insights into the mechanisms underlying age-associated dysfunction of temporal cortex.

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“…There are a large number of mitochondria in the human cerebellar Purkinje cell layer [36], with the number estimated to be even greater than that in the frontal or temporal cortices and putamen [37]. In addition, in rats, the cerebellum demonstrates the lowest levels in any brain region of magnesium superoxide dismutase, the antioxidant enzyme [38].…”

Section: Discussionmentioning

confidence: 99%

Case-Control Study of Nutritional Antioxidant Intake in Essential Tremor

Louis

Jurewicz²,

Parides

2005

Neuroepidemiology

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The theory that oxidative stress is involved in the pathogenesis of neurodegenerative diseases has received considerable attention and studies have linked these diseases to the diminished use of antioxidant vitamins (vitamins E and C) and other dietary antioxidants. Essential tremor (ET) is a chronic, progressive disease. One possible disease mechanism is neurodegenerative. Whether nutritional antioxidant use differs between ET cases and controls is not known. Using a case-control design, we conducted detailed dietary assessments and tested the hypothesis that diminished use of nutritional antioxidants is associated with ET. Data on diet were collected on 156 ET cases and 220 controls using a semi-quantitative food-frequency questionnaire. There was no evidence that current nutritional antioxidant exposure differs in ET cases and controls. This does not exclude the possibility that nutritional antioxidant exposure was lower in ET cases prior to their disease onset.

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Age-associated changes of superoxide dismutase and catalase activities in the rat brain

Cited by 71 publications

References 30 publications

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

The antioxidant effect of astaxanthin is higher in young mice than aged: a region specific study on brain

Differential Proteomics Analysis of Specific Carbonylated Proteins in the Temporal Cortex of Aged Rats: The Deterioration of Antioxidant System

Case-Control Study of Nutritional Antioxidant Intake in Essential Tremor

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