Induction Effect of Microalgae Scenedesmus Dimorphus Against Hematology on Mice (Mus Musculus) Suffering Anemia Diseases

Abstract

Objective: This study aims to investigate the potential of Scenedesmus dimorphus as a cure for aplastic anemia in mice (Mus musculus).Methods: Fifty male mice divided into five groups, mice suffering anemia due to induction of chloramphenicol. Oral administrated of S. dimorphus for 28 days with a dose of 2.5 g/50 ml, 5.0 g/50 ml, and 7.5 g/50 ml, respectively, to cure aplastic anemia in mice and samcobion as standard drug.Results: Induction of chloramphenicol caused the mice to suffering aplastic anemia and weight loss in mice. Biomass of S. dimorphus has an effect of against hematological parameters and total blood count estimation. The result shows significant (p<0.05 ANOVA) on weight gain, an increase of erythrocyte counts, and hemoglobin level, whereas an increase of hematocrit and reticulocyte values have non-significant, and a dose of S. dimorphus 5.0 g/50 ml were the treatment most effective for anemia in mice.Conclusion: Based on the results of this study, S. dimorphus biomass has the healing benefit of aplastic anemia due to the administration of chloramphenicol.

The nutraceutical effect of Scenedesmus dimorphus for obesity and nonalcoholic fatty liver disease–linked metabolic syndrome

“…Scenedesmus dimorphus as a nutraceutical can repair bone marrow damage due to aplastic anemia. BW, red blood cells, hemoglobin, hematocrit values, and reticulocytes increased in anemia mice (Armaini et al, 2018).…”

Mikoalga Spirulina Platensis Sebagai Suplemen Untuk Meningkatkan Gizi Dan Imunitas Balita Di Posyandu Anggrek 2 Kelurahan Seberang Padang, Kota Padang

“…Kandungan Lipid pada mikroalga sangat baik untuk mengendalikan obesitas pada balita dengan status gizi kelebihan berat badan (Armaini, et al, 2020) Mikroalga Scenedesmus dimorphus yang di kultur dalam media BBM dengan sumber nitrogen urea mampu menghasilkan karotenoid yang tinggi, seperti beta-karoten sebagai provitamin A dan karotenoid (Armaini, et al 2016) juga dikenal memiliki nilai terapeutik, termasuk anti-inflmmatory dan anti-kanker (Iyer et al, 2008). Mikroalga Scenedesmus dimorphus bermanfaat sebagai anti-anemia karena memiliki anti oksidan tinggi, asam folat dan zat besi (Armaini et al, 2018). Miroalga mengandung antioksidan yang cukup tinggi dan berbagai vitamin yang penting untuk kesehatan (Becker et al, 2004;Chu et al, 2010).…”