Induction and transient suppression of long-term potentiation in the peri- and postrhinal cortices following theta-related stimulation of hippocampal field CA1

Cousens, Graham; Otto, Tim

doi:10.1016/s0006-8993(97)01151-7

Cited by 29 publications

(34 citation statements)

References 51 publications

(7 reference statements)

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“…The current study aims to extend our own preliminary findings and those of Cousens and Otto (1998) by examining plasticity in the CA1 to perirhinal cortex projection and also examining the pharmacological properties of this projection using the NMDA receptor antagonist MK-801 and the AMPA/ kainate receptor antagonist CNQX (Honoré et al, 1988). Further, by using paired-pulse facilitation (PPF), a technique often used to determine the locus of change following potentiation, we wish to determine whether the potentiation observed in the CA1 to perirhinal cortex projection is pre-or postsynaptic in nature.…”

Section: Introductionmentioning

confidence: 64%

“…Despite these studies there has been little work describing either the electrophysiological or the pharmacological properties of these projections. Recently, Craig and Commins (2005; have reported that projections from both the area CA1 and the subiculum to the entorhinal cortex can sustain LTP while Cousens and Otto (1998) succeeded in inducing LTP in the CA1 to perirhinal cortex projection using theta burst stimulation (TBS). Initial work in our lab supports the findings of Cousens and Otto; the CA1 to perirhinal pathway can sustain LTP for at least an hour following 250 Hz high-frequency stimulation (HFS) (Kealy and Commins, unpublished observations), suggesting that the pathway going from the area CA1 to the perirhinal cortex is electrophysiologically active and could play a role in memory formation.…”

Section: Introductionmentioning

confidence: 99%

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Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor

Kealy

Commins

2009

Brain Research

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The CA1 to perirhinal cortex projection is one of multiple hippocampal-neocortical projections considered to be involved in memory consolidation. This projection has been shown to sustain long-term potentiation (LTP) following stimulation of CA1. Here we examined the pharmacological properties underpinning the plasticity observed in this projection. A stimulating electrode was inserted into the area CA1 and a recording electrode was inserted into the perirhinal cortex of urethane-anaesthetised Wistar rats. Rats (n = 6 in each drug group) were administered with either saline (0.09%), MK-801 (NMDA antagonist; 0.1 mg/kg) or CNQX (AMPA/kainate antagonist; 1.5 mg/kg). Baseline recordings were made for 10 min by stimulating area CA1 (0.05 Hz stimulation protocol). High-frequency stimulation (HFS; 250 Hz) was performed and post-HFS fEPSP recordings were made for 1 h (0.05 Hz, as above). Baseline and post-HFS paired-pulse facilitation (PPF) recordings were performed across six different interpulse intervals. CA1 and perirhinal cortex tissue samples were taken from the stimulated and unstimulated hemispheres of each rat brain and analysed using a brain-derived neurotrophic factor (BDNF) ELISA. Results indicate that LTP was induced in the saline and MK-801 groups but not in the CNQX group; fEPSPs in the latter group rapidly returned to baseline levels following a short period of post-tetanic potentiation. Drug treatment and HFS had no effect on PPF levels. Drug treatment IntroductionThe hippocampal formation is an important structure for learning and memory (Scoville and Milner, 1957;O'Keefe and Nadel, 1978;Squire, 1992). Although not the actual site of storage for long-term memory, the hippocampal formation acts as the site of association of sensory information (Rolls, 1996) and is required to form long-term memories. Long-term storage is believed to occur in the neocortex with the hippocampal formation acting in an integrative role (Squire et al., 1984;Squire, 1992;McClelland et al., 1995;Squire and Alvarez, 1995). Long-term potentiation (LTP) is a phenomenon first described in the rabbit hippocampus by Bliss and Lømo

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Section: Introductionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor

Kealy

Commins

2009

Brain Research

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Section: Hippocampal and Parahippocampal Projectionsmentioning

confidence: 99%

“…As well as generating fEPSPs in the perirhinal cortex, stimulation of the monosynaptic return projection from the hippocampus to the perirhinal cortex can induce changes in long-term synaptic plasticity (Cousens and Otto, 1998;Commins, 2009, 2010). Stimulation of area CA1 using 300 Hz HFS in the freely moving rat (Ivanco and Racine, 2000) and, 100 Hz theta-burst stimulation (Cousens and Otto, 1998) and 250 Hz Commins, 2009, 2010) in the anaesthetised rat can induce LTP in the perirhinal cortex. However, Ivanco and Racine (2000) observed that synaptic changes in the perirhinal cortex following HFS of CA1 took several sessions to induce, indicating that this projection may be resistant to activitydependent changes in synaptic plasticity but the findings of Cousens and Otto (1998) appear to contradict this view as the LTP observed during their experiment was robust and easily induced with their stimulation protocol.…”

Section: Hippocampal and Parahippocampal Projectionsmentioning

confidence: 99%

“…Stimulation of area CA1 using 300 Hz HFS in the freely moving rat (Ivanco and Racine, 2000) and, 100 Hz theta-burst stimulation (Cousens and Otto, 1998) and 250 Hz Commins, 2009, 2010) in the anaesthetised rat can induce LTP in the perirhinal cortex. However, Ivanco and Racine (2000) observed that synaptic changes in the perirhinal cortex following HFS of CA1 took several sessions to induce, indicating that this projection may be resistant to activitydependent changes in synaptic plasticity but the findings of Cousens and Otto (1998) appear to contradict this view as the LTP observed during their experiment was robust and easily induced with their stimulation protocol. In general, however, the findings that the CA1 to perirhinal cortex projection can sustain both shortand long-term changes in activity-dependent synaptic plasticity indicate that this projection may therefore play a role in the storage or consolidation of perirhinal-dependent memories (Hasselmo and McClelland, 1999).…”

Section: Hippocampal and Parahippocampal Projectionsmentioning

confidence: 99%

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The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Kealy

Commins

2011

Progress in Neurobiology

106

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Plasticity at hippocampal to prefrontal cortex synapses: Dual roles in working memory and consolidation

2000

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The involvement of the hippocampus and the prefrontal cortex in cognitive processes and particularly in learning and memory has been known for a long time. However, the specific role of the projection which connects these two structures has remained elusive. The existence of a direct monosynaptic pathway from the ventral CA1 region of the hippocampus and subiculum to specific areas of the prefrontal cortex provides a useful model for conceptualizing the functional operations of hippocampal‐prefrontal cortex communication in learning and memory. It is known now that hippocampal to prefrontal cortex synapses are modifiable synapses and can express different forms of plasticity, including long‐term potentiation, long‐term depression, and depotentiation. Here we review these findings and focus on recent studies that start to relate synaptic plasticity in the hippocampo‐prefrontal cortex pathway to two specific aspects of learning and memory, i.e., the consolidation of information and working memory. The available evidence suggests that functional interactions between the hippocampus and prefrontal cortex in cognition and memory are more complex than previously anticipated, with the possibility for bidirectional regulation of synaptic strength as a function of the specific demands of tasks. Hippocampus 10:438–446, 2000 © 2000 Wiley‐Liss, Inc.

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Induction and transient suppression of long-term potentiation in the peri- and postrhinal cortices following theta-related stimulation of hippocampal field CA1

Cited by 29 publications

References 51 publications

Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor

Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor

The rat perirhinal cortex: A review of anatomy, physiology, plasticity, and function

Plasticity at hippocampal to prefrontal cortex synapses: Dual roles in working memory and consolidation

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