1998
DOI: 10.1002/(sici)1521-4141(199809)28:09<2817::aid-immu2817>3.0.co;2-m
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Induction and functional characterization of β 2-microglobulin (β2-μ)-free HLA class I heavy chains expressed by β2-μ-deficient human FO-1 melanoma cells

Abstract: The frequent loss of beta2-microglobulin (beta2-mu) in malignant cells has stimulated interest in the functional characteristics of beta2-mu-free HLA class I heavy chains, since this information contributes to assess the impact of beta2-mu abnormalities on the interaction of malignant cells with immune cells. Therefore, the present study has investigated the ability of beta2-mu-free HLA class I heavy chains to modulate NK cell-mediated lysis of melanoma cells and to present melanoma-associated antigen (MAA)-de… Show more

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Cited by 12 publications
(11 citation statements)
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“…Herein, we confirm the extreme instability of Daudi heavy chains, but at the same time conclusively show that, unlike the other ␤ 2 m-deficient human cells described so far (7)(8)(9)(10)(11)(12)(13)(14), Daudi cells synthesize class I molecules with biochemical features intermediate between those of folded and unfolded heavy chains, and surface-express them at low levels. Thus, we propose amendments and refinements in the fields of class I folding as well as virus and tumor immune surveillance.…”
Section: Discussionmentioning
confidence: 98%
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“…Herein, we confirm the extreme instability of Daudi heavy chains, but at the same time conclusively show that, unlike the other ␤ 2 m-deficient human cells described so far (7)(8)(9)(10)(11)(12)(13)(14), Daudi cells synthesize class I molecules with biochemical features intermediate between those of folded and unfolded heavy chains, and surface-express them at low levels. Thus, we propose amendments and refinements in the fields of class I folding as well as virus and tumor immune surveillance.…”
Section: Discussionmentioning
confidence: 98%
“…To our knowledge, class I HLA heavy chains from ␤ 2 m-deficient cells other than Daudi lack conformational epitopes (7)(8)(9)(10)(11)(12)(13)(14). To confirm this difference in a controlled experiment, we compared side-by-side Daudi cells, three ␤ 2 m-defective cell lines characterized by three different groups (KJ-29 (12), FO-1 (7), and LoVo (10)), and two stable ␤ 2 m transfectants (Fig.…”
Section: The ␤ 2 M-free Class I Heavy Chains Synthesized By Daudi Celmentioning
confidence: 99%
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“…No free HLA-A, -B, -C heavy chains have been detected at the surface of most β 2 m-defective cell lines described to date (Fellous et al, 1977;D'Urso et al, 1992;Gattoni-Celli et al, 1992;Wang et al, 1993;Bicknell et al, 1994;Porgador et al, 1997). In a recent report (Wang et al, 1998) the surface expression of HC-10-reacting, β 2 m-free HLA-A25 and -B8 heavy chains was detected in FO-1 cells. This, however, required treatment with IFN-α and hypothermia.…”
Section: Discussionmentioning
confidence: 99%