2002
DOI: 10.1016/s1534-5807(02)00369-6
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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Abstract: Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles downstream of RANKL. We show here that RANKL selectively induces NFATc1 expression via these two pathways. RANKL also evokes Ca(2+) oscillations that lead to calcineurin-mediated activation of NFATc1, and therefore triggers a sustained NFATc1-dependent transcriptional program during osteoclast differentiation. We also show that NFATc1-deficient… Show more

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Cited by 2,266 publications
(2,568 citation statements)
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References 59 publications
(2 reference statements)
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“…JNK1 activated by RANKL protects osteoclast precursors from RANKL-induced apoptosis and regulates osteoclastogenesis through the phosphorylation of c-Jun, a component of the dimeric transcription factor AP-1 [25]. C-Fos, another component of AP-1, is an essential transcription factor for osteoclast differentiation [21,22,26]. Up-regulation of c-Fos by the p38 pathway has been recently reported [27].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…JNK1 activated by RANKL protects osteoclast precursors from RANKL-induced apoptosis and regulates osteoclastogenesis through the phosphorylation of c-Jun, a component of the dimeric transcription factor AP-1 [25]. C-Fos, another component of AP-1, is an essential transcription factor for osteoclast differentiation [21,22,26]. Up-regulation of c-Fos by the p38 pathway has been recently reported [27].…”
Section: Discussionmentioning
confidence: 99%
“…RANKL stimulation also induces the expression of c-Fos and NFATc1, essential transcription factors in RANKL-induced osteoclastogenesis [21,22]. Thus, we used sqRT-PCR to examine the expression of c-Fos and NFATc1 during RANKL-mediated osteoclastogenesis.…”
Section: Decreased Osteoclastogenic Ability Of 4-1bb -/-Bmm Ex Vivomentioning
confidence: 99%
“…*p \ 0.01, **p \ 0.05 specifically stimulated, and IjB signals. And costimulatory immunoreceptors lead to the robust induction of NFATc1, which is a necessary and sufficient factor for osteoclast differentiation (Takayanagi 2007;Walsh et al 2006;Takayanagi 2005Takayanagi , 2002Asagiri et al 2005). We examined whether luteolin could modulate the expressions of these genes.…”
Section: Discussionmentioning
confidence: 99%
“…The TRAF-binding domains of RANK are important for the RANK-dependent induction of NF-B and JNK (21,23). In addition, the signaling pathways via the transcription factors c-Fos and nuclear factor of activated T cells c1 (NF-ATc1) seem to be important for RANKL-induced osteoclastogenesis, as outlined in recent studies (24)(25)(26). RANKL also activates the antiapoptotic serine/ threonine kinase protein kinase B/Akt through a signaling complex involving c-Src and TRAF6, which interact with one another and with RANK after receptor engagement (27).…”
mentioning
confidence: 92%