Inducible clindamycin resistance in Staphylococcus aureus

Gupta, Varsha; Datta, Priya; Rani, Hena; Chander, Jagdish

doi:10.4103/0022-3859.57393

Cited by 49 publications

(58 citation statements)

References 9 publications

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“…In the present study, 15.53% of the MSSA isolates showed iMLSB resistance, which correlates with the findings by Delialiogu et al, who reported 10.7% iMLSB resistance in the MSSA isolates and Gupta at al who reported 17.3% iMLSB resistance in the MSSA isolates [3] [12].…”

Section: Discussionsupporting

confidence: 81%

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Prevalance of inducible clindamycin resistance of Staphylococcus aureus from various clinical specimens by D test in tertiary care hospital

chudasama¹,

Solanki²,

Vadsmiya³

et al. 2014

IOSRJDMS

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Section: Discussionsupporting

confidence: 81%

“…Angel et al have not found any cMLSB resistance in the S.aureus strains. However, Gupta et al have reported 19% cMLB resistance, 46% of which were of the MRSA type and 10% were of the MSSA type [10] [12]. 15.65% S.aureus strains showed the MSB phenotype in the present study.…”

Section: Discussionmentioning

confidence: 50%

Prevalance of inducible clindamycin resistance of Staphylococcus aureus from various clinical specimens by D test in tertiary care hospital

chudasama¹,

Solanki²,

Vadsmiya³

et al. 2014

IOSRJDMS

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“…Clindamycin, the macrolide-lincosamide-streptogramin B (MLSB) antimicrobial group is an alternative treatment option for S. aureus infections 9,8 . The use of this antimicrobial agent in the presence of erythromycin resistance is of a great concern, since there is a possibility of induction of cross-resistance mechanism among members of the MLSB 10 .…”

Section: Introductionmentioning

confidence: 99%

Inducible clindamycin resistance and nasal carriage rates of<i> Staphylococcus aureus </i>among healthcare workers and community members

Mahmoud¹,

Albadawy²,

Bolis³

et al. 2015

Afr H. Sci.

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Background: Nasal carriage of Staphylococcus aureus is becoming an increasing problem among healthcare workers and community individuals Objectives: To determine the prevalence of methicillin-resistant S. aureus (MRSA) nasal colonization and inducible clindamycin resistance (ICR) of S. aureus among healthcare workers at Soba University Hospital and community members in Khartoum State, Sudan. Conclusion: MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission of MRSA. The occurrence of ICR in S. aureus is of a great concern, D-test should be carried out routinely in our hospitals to avoid therapeutic failure.

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“…These findings were in accordance with Date et al, (2012) who found 26.43% of total isolates showed constitutive resistance, which was more frequent in MRSA 52.63% and MR-CoNS 78.95% and Shantala et al, (2011) who found a higher incidence of cMLSB in S. aureus 18.26% (19,20) . Gupta et al, (2009); have reported cMLSB resistance in 19% of total isolates of which 46%were MRSA type and ten%were MSSA type (21) . In this study, higher incidence of cMLSB resistance was found in CoNS 41.57%.…”

Section: Discussionmentioning

confidence: 99%

Inducible Clindamycin Resistance in Clinical Isolates of Staphylococci

Zaher¹

2017

IAM

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Background: The increasing frequency of methicillin-resistant Staphylococcus aureus (MRSA) infections and the changing patterns of antimicrobial resistance have led to renewed interest in the use of macrolide-lincosamidestreptogramin B (MLSB) antibiotics to treat such infections. However, resistance to MLSB antibiotics has been reported to be mediated by the msrA gene coding for efflux mechanism and erm gene which encoding the enzymes conferring resistance to MLSB antibiotics. Routine antibiotic sensitivity tests for clindamycin may fail to detect inducible clindamycin resistance due to the presence of the erm gene thereby resulting in failure of treatment. Aim: This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. Materials and Methods: A total of 247 strains of staphylococci (S. aureus -158 and coagulasenegative staphylococci (CoNS) -89), isolated from various clinical samples were included in this study. The isolates were identified using conventional methods. Inducible clindamycin resistance was tested by D test as per the CLSI guidelines. Results: Of total 247 isolates included in this study 52(21.05%) were MRSA, 67(27.13%) were Methicillin Resistant Coagulase Negative Staphylococci (MR-CoNS). Inducible clindamycin resistance was detected in 13.46 % of 52 MRSA and 2.99% of 67 MR-CoNS. Conclusion: Staphylococcal isolates, particularly MRSA, must be tested routinely by the D-test before treatment so that the clindamycin drug is used effectively and for maximum clinical utility.

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Inducible clindamycin resistance in Staphylococcus aureus

Cited by 49 publications

References 9 publications

Prevalance of inducible clindamycin resistance of Staphylococcus aureus from various clinical specimens by D test in tertiary care hospital

Prevalance of inducible clindamycin resistance of Staphylococcus aureus from various clinical specimens by D test in tertiary care hospital

Inducible clindamycin resistance and nasal carriage rates of<i> Staphylococcus aureus </i>among healthcare workers and community members

Inducible Clindamycin Resistance in Clinical Isolates of Staphylococci

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