Background: Nasal carriage of Staphylococcus aureus is becoming an increasing problem among healthcare workers and community individuals Objectives: To determine the prevalence of methicillin-resistant S. aureus (MRSA) nasal colonization and inducible clindamycin resistance (ICR) of S. aureus among healthcare workers at Soba University Hospital and community members in Khartoum State, Sudan. Conclusion: MRSA nasal carriage among healthcare workers needs infection control practice in hospitals to prevent transmission of MRSA. The occurrence of ICR in S. aureus is of a great concern, D-test should be carried out routinely in our hospitals to avoid therapeutic failure.